1.1 1469 info:srw/schema/1/mods-v3.3xml journalArticle Article A1 Sylvie De Buck aut author ug_GE35 ug_UZGent 0000-0001-8048-0582 Anni Jacobs aut author ug_WE09 Marc Van Montagu aut author ug_WE09 Anna Depicker aut author ug_WE09 0000-0003-0105-7407 eng After Agrobacterium-mediated plant transformation, multiple T-DNAs frequently integrate at the same position in the plant genome, resulting in the formation of inverted and direct repeats. Because these inverted repeats cannot be amplified and analyzed by PCR, Arabidopsis root cells were co-transformed with two different T-DNAs with distinct sequences adjacent to the T-DNA borders. Nine direct or inverted T-DNA border junctions were analyzed at the sequence level. Precise end-to-end fusions were found between two right border ends, whereas imprecise fusions and filler DNA were present in T-DNA linkages containing a left border end. The results suggest that end-to-end ligation of double-stranded T-DNAs occurs especially between right T-DNA ends and that illegitimate recombination on the basis of microhomology, deletions, repair activities and insertions of filler DNA is involved in the formation of left border T-DNA junctions. Therefore, a similar illegitimate recombination mechanism is proposed that is involved in the formation of complex T-DNA inserts as well as in the integration of the T-DNA in the plant genome. Biology and Life Sciences GENOME PROTEIN GENE STRANDED-DNA MEDIATED TRANSFORMATION ILLEGITIMATE RECOMBINATION PLANT-CELLS AGROBACTERIUM-TUMEFACIENS VIRD2 CONJUGATION ARABIDOPSIS http://hdl.handle.net/1854/LU-112589 10.1046/j.1365-313X.1999.00602.x 000084156700004 0960-7412 1999 0960-7412 1999 20 3 295 304 1999 No license (in copyright) published https://biblio.ugent.be/publication/112589/file/4161283 application/pdf restricted ug 112589 2004-01-14T13:35:00Z 2026-03-31T06:57:36Z A1 VABB-1 1 info:srw/schema/1/mods-v3.3xml dissertation D1 Sylvie De Buck aut author ug_GE35 ug_UZGent 0000-0001-8048-0582 Anna Depicker promoter ug_WE09 0000-0003-0105-7407 Marc Van Montagu promoter ug_WE09 dut Biology and Life Sciences http://hdl.handle.net/1854/LU-01JMH9KGDH2YQHBW7RX2C17GGT Var. pag. p. Gent Universiteit Gent. Faculteit Wetenschappen 2000 No license (in copyright) published Gent : Faculteit Wetenschappen https://biblio.ugent.be/publication/01JMH9KGDH2YQHBW7RX2C17GGT/file/01JMH9PTP4W1N7ZJFFAARZGH40 application/pdf restricted ug 01JMH9KGDH2YQHBW7RX2C17GGT 2025-02-20T09:04:16Z 2026-03-31T14:19:06Z D1 2 info:srw/schema/1/mods-v3.3xml conference Meeting Abstract C3 Mathis Hildonen aut author Andrea Ciolfi aut author Marco Ferilli aut author Camilla Cappelletti aut author Al Alam Chadi aut author David Amor aut author Tahsin Stefan Barakat aut author Valerie Benoit aut author Ohad Birk aut author Bert Callewaert aut author ug_GE31 ug_UZGent 0000-0002-9743-4205 Ana Cazurro-Gutierrez aut author Matthias De Wachter aut author Martine Doco-Fenzy aut author Paulino Gomez-Puertas aut author Trine Bjorg Hammer aut author Rami Abou Jamra aut author Rauan Kaiyrzhanov aut author Shinichi Kameyama aut author Boris Keren aut author Christina Kresge aut author Ilona Krey aut author Damien Lederer aut author Inigo Marcos-Alcalde aut author Reza Maroofian aut author Naomichi Matsumoto aut author Takeshi Mizuguchi aut author Lip-Hen Moey aut author Angela T. Morgan aut author Francina Munell aut author Pardis Nourbakhsh aut author Konrad Platzer aut author Beth A. Pletcher aut author David Rospardo aut author Lynne Rumping aut author Gholamreza Shariati aut author Katalin Szakszon aut author Kristof Van Schil aut author Edgard Verdura aut author Julie Vogt aut author Evangeline Wassmer aut author Mina Zamani aut author Zeynep Tumer aut author Marco Tartaglia aut author 58th Conference of the European-Society-of-Human-Genetics (ESHG) eng Medicine and Health Sciences Biology and Life Sciences http://hdl.handle.net/1854/LU-01KKBW0C69EPRS1GFEEGNTM9ZA 001671157905143 1018-4813 1476-5438 P16.030.A

2025 1018-4813 1476-5438 2025 33 Supplement 1 953 953 2025 published https://www.nature.com/collections/jahdgeidhf https://www.nature.com/articles/s41431-025-01935-5 ug 01KKBW0C69EPRS1GFEEGNTM9ZA 2026-03-10T12:37:02Z 2026-03-31T05:33:02Z C3 3 info:srw/schema/1/mods-v3.3xml bookChapter B2 Marc Antrop aut author ug_WE12 eng Science General http://hdl.handle.net/1854/LU-125587 29-34 p. 2000 29-34 p. 2000 29 34 2000 published ug 125587 2004-01-14T13:36:00Z 2026-03-31T07:19:53Z B2 VABB-4 4 info:srw/schema/1/mods-v3.3xml dissertation D1 Veronique Storme aut author ug_WE02 0000-0003-4762-6580 Wout Boerjan promoter ug_WE09 0000-0003-1495-510X eng Biology and Life Sciences http://hdl.handle.net/1854/LU-8137255 280 + annexe p. Ghent, Belgium Ghent University. Faculty of Sciences 2016 No license (in copyright) published Zwijnaarde : Technologiepark (FSVM-gebouw) https://biblio.ugent.be/publication/8137255/file/8137287 application/pdf restricted https://biblio.ugent.be/publication/8137255/file/8770368 application/pdf private ug 8137255 2016-11-10T09:27:44Z 2026-03-31T14:28:05Z D1 5 info:srw/schema/1/mods-v3.3xml conference C3 Bieke Decaesteker aut author ug_UGent 0000-0003-2264-781X Sara De Brouwer aut author ug_UGent Robrecht Cannoodt aut author ug_WE02 0000-0003-3641-729X Dries Rombaut aut author 0000-0001-7526-7541 Wouter Van Loocke aut author ug_UGent Annelies Fieuw aut author ug_UGent Fanny De Vloed aut author ug_UZGent Pieter-Jan Volders aut author ug_UGent 0000-0002-2685-2637 Björn Menten aut author ug_GE31 ug_UZGent 0000-0001-8182-659X Rogier Versteeg aut author Patrick Reynolds aut author Michael Hogarty aut author Jan Koster aut author Franki Speleman aut author ug_GE31 0000-0002-6628-8559 Katleen De Preter aut author ug_GE31 0000-0002-7726-5096 4th OncoPoint research seminar eng Neuroblastoma (NB) is an aggressive lethal pediatric cancer of the developing sympatho-adrenergic nervous system and characterised by a very low mutation burden while exhibiting highly recurrent DNA copy number alterations. Chromosome 2p gain and more specifically MYCN amplification is observed in most of the high risk cases. Using high-resolution DNA copy number analysis, we identified three NB tumours and two NB cell lines with SOX11 focal amplification. SOX11 is located on 2p25 but independently amplified of MYCN, and a key gene involved in the development of the sympatho-adrenergic lineage and contributing to the NB phenotype as demonstrated by reduced colony formation capacity and induction of G1-S cell cycle arrest upon knock down in NB cells. The SOX11 gene consists of one exon and a very long 3’UTR, targeted by miRNA-204 and miRNA-542-3p, both lower expressed in NB tumours as compared to neuroblasts. Additionally, lnc-SOX11-1:1 is partially overlapping with this 3’UTR and transcribed in sense direction with SOX11. Recently high 3’UTR:CDS ratio’s for neuronal genes and specifically SOX11 were reported, indicating that 3’UTR:CDS ratio can play a role in the development of neuroblastoma. Interestingly, whole genome sequencing of the neuroblastoma CHP-126 cell line revealed a remarkable amplification consisting of the 3’UTR and 5’UTR of SOX11, but excluding the SOX11 exon. Nevertheless, SOX11 mRNA and protein levels were very high while multiple splicing events affecting the 3’UTR were noted. Further analyses are ongoing to explain these enigmatic observations. Biology and Life Sciences http://hdl.handle.net/1854/LU-7174333 2016 2016 10 10 2016 published ug 7174333 2016-04-04T19:19:08Z 2026-03-31T14:25:13Z C3 6 info:srw/schema/1/mods-v3.3xml journalArticle Article A1 Brian D Hobbs aut author Kim de Jong aut author Maxime Lamontagne aut author Yohan Bosse aut author Nick Shrine aut author Maria Soler Artigas aut author Louise V Wain aut author Ian P Hall aut author Victoria E Jackson aut author Annah B Wyss aut author Stephanie J London aut author Kari E North aut author Nora Franceschini aut author David P Strachan aut author Terri H Beaty aut author John E Hokanson aut author James D Crapo aut author Peter J Castaldi aut author Robert P Chase aut author Traci M Bartz aut author Susan R Heckbert aut author Bruce M Psaty aut author Sina A Gharib aut author Pieter Zanen aut author Jan W Lammers aut author Matthijs Oudkerk aut author HJ Groen aut author Nicholas Locantore aut author Ruth Tal-Singer aut author Stephen I Rennard aut author Jurgen Vestbo aut author Wim Timens aut author Peter D Pare aut author Jeanne C Latourelle aut author Josee Dupuis aut author George T O'Connor aut author Jemma B Wilk aut author Woo Jin Kim aut author Mi Kyeong Lee aut author Yeon-Mok Oh aut author Judith M Vonk aut author Harry J de Koning aut author Shuguang Leng aut author Steven A Belinsky aut author Yohannes Tesfaigzi aut author Ani Manichaikul aut author Xin-Qun Wang aut author Stephen S Rich aut author R Graham Barr aut author David Sparrow aut author Augusto A Litonjua aut author Per Bakke aut author Amund Gulsvik aut author Lies Lahousse aut author ug_FW03 0000-0002-3494-4363 Guy Brusselle aut author ug_FW01 ug_GE35 ug_UZGent 0000-0001-7021-8505 Bruno H Stricker aut author Andre G Uitterlinden aut author Elizabeth J Ampleford aut author Eugene R Bleecker aut author Prescott G Woodruff aut author Deborah A Meyers aut author Dandi Qiao aut author David A Lomas aut author Jae-Joon Yim aut author Deog Kyeom Kim aut author Iwona Hawrylkiewicz aut author Pawel Sliwinski aut author Megan Hardin aut author Tasha E Fingerlin aut author David A Schwartz aut author Dirkje S Postma aut author William MacNee aut author Martin D Tobin aut author Edwin K Silverman aut author H Marike Boezen aut author Michael H Cho aut author eng Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide(1). We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 x 10(-6)) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples(2-7), while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis(8,9) (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity(10). We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases. Medicine and Health Sciences Biology and Life Sciences GENOME-WIDE ASSOCIATION SURFACTANT PROTEIN-D AIR-FLOW OBSTRUCTION SMOKING-BEHAVIOR COMPLEX TRAITS I INTERFERON VARIANTS COPD SUSCEPTIBILITY EMPHYSEMA http://hdl.handle.net/1854/LU-8537630 10.1038/ng.3752 000394917800016 1061-4036 1546-1718 2017 1061-4036 1546-1718 2017 49 3 426 432 2017 No license (in copyright) published https://biblio.ugent.be/publication/8537630/file/8537631 application/pdf restricted ug 8537630 2017-11-16T10:06:35Z 2026-03-31T13:12:36Z A1 VABB-1 7 info:srw/schema/1/mods-v3.3xml bookEditor B3 Thomas Coomans edt editor Herman De Dijn edt editor Jan De Maeyer edt editor Rajesh Heynickx edt editor Bart Verschaffel edt editor ug_TW01 eng This book collects 14 theoretical and historical articles on (the notion of) 'sacred place' and the reuse of sacred places. Philosophy and Religion Sacred Place sacrality http://hdl.handle.net/1854/LU-2015967 9789058678423 284 p. Leuven, Belgium Leuven University Press 2012 9 No license (in copyright) published https://biblio.ugent.be/publication/2015967/file/6765822 application/pdf restricted https://biblio.ugent.be/publication/2015967/file/6765823 application/pdf restricted ug 2015967 2012-02-02T12:14:50Z 2026-03-31T13:12:43Z B3 VABB-3 8 info:srw/schema/1/mods-v3.3xml journalArticle Article A1 Wouter Coppieters aut author Alex Van De Weghe aut author Luc Peelman aut author ug_DI07 0000-0003-3853-5310 Anna Depicker aut author ug_WE09 0000-0003-0105-7407 Alex Van Zeveren aut author ug_UGent Yves Bouquet aut author eng Medicine and Health Sciences http://hdl.handle.net/1854/LU-202224 A1993LJ02100002 0268-9146 163-170 p. 1993 0268-9146 1993 24 3 163 170 1993 published ug 202224 2004-01-14T13:42:00Z 2026-03-31T13:16:26Z A1 VABB-1 9 info:srw/schema/1/mods-v3.3xml journalArticle Article A1 Bart Verschaffel aut author ug_TW01 eng The perception and aesthetic experience of places concerns the appreciation of what is recognised as a site. It presupposes readability. A place is here, surrounded by other, similar places, that are there. Beyond, elsewhere, there is always a hinterland: beyond my world, is the World. One can only imagine the World, but the World can announce itself here, as an aspect or element of what we effectively perceive, such as a view onto a distance or the horizon. A (meaningful) environment acquires, moreover, an aesthetic quality when the successful structuring of the interplay of Place and World suggests an image to the aesthetic view: when the site is recognised as exemplifying the “topos” of a “lovely place,” or a locus amoenus: an enclosed, secret garden (“paradise”), or a “House before the Distant.” Arts and Architecture Architectural experience environmental aesthetics landscape locus amoenus topophilia http://hdl.handle.net/1854/LU-8744568 10.1080/13264826.2021.2023341 000752305500001 1326-4826 1755-0475 2021 1326-4826 1755-0475 2021 25 3 282 291 2021 No license (in copyright) published https://biblio.ugent.be/publication/8744568/file/8752146 application/pdf restricted https://biblio.ugent.be/publication/8744568/file/8752305 application/pdf ug 8744568 2022-03-09T17:07:01Z 2026-03-31T13:39:51Z A1 VABB-1 10 1.1title any "dna loci"titleanydna loci