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The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis

Md Hasan Zaki, Peter Vogel, RK Subbarao Malireddi, Mathilde Body-Malapel, Paras K Anand, John Bertin, Douglas R Green, Mohamed Lamkanfi UGent and Thirumala-Devi Kanneganti (2011) CANCER CELL. 20(5). p.649-660
abstract
NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been characterized. We analyzed mice deficient in Nlrp12 to study its role in inflammatory diseases such as colitis and colorectal tumorigenesis. We show that Nlrp12-deficient mice are highly susceptible to colon inflammation and tumorigenesis, which is associated with increased production of inflammatory cytokines, chemokines, and tumorigenic factors. Enhanced colon inflammation and colorectal tumor development in Nlrp12-deficient mice are due to a failure to dampen NF-kappa B and ERK activation in macrophages. These results reveal a critical role for NLRP12 in maintaining intestinal homeostasis and providing protection against colorectal tumorigenesis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PROTEIN, SUSCEPTIBILITY, MICE, ACTIVATION, CUTTING EDGE, ULCERATIVE-COLITIS, BOWEL-DISEASE, COLORECTAL-CANCER, NF-KAPPA-B, CROHNS-DISEASE
journal title
CANCER CELL
Cancer Cell
volume
20
issue
5
pages
649 - 660
Web of Science type
Article
Web of Science id
000297086200012
JCR category
ONCOLOGY
JCR impact factor
26.566 (2011)
JCR rank
3/190 (2011)
JCR quartile
1 (2011)
ISSN
1535-6108
DOI
10.1016/j.ccr.2011.10.022
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1964187
handle
http://hdl.handle.net/1854/LU-1964187
date created
2011-12-09 08:51:03
date last changed
2013-01-30 09:41:21
@article{1964187,
  abstract     = {NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been characterized. We analyzed mice deficient in Nlrp12 to study its role in inflammatory diseases such as colitis and colorectal tumorigenesis. We show that Nlrp12-deficient mice are highly susceptible to colon inflammation and tumorigenesis, which is associated with increased production of inflammatory cytokines, chemokines, and tumorigenic factors. Enhanced colon inflammation and colorectal tumor development in Nlrp12-deficient mice are due to a failure to dampen NF-kappa B and ERK activation in macrophages. These results reveal a critical role for NLRP12 in maintaining intestinal homeostasis and providing protection against colorectal tumorigenesis.},
  author       = {Zaki, Md Hasan and Vogel, Peter and Malireddi, RK Subbarao and Body-Malapel, Mathilde and Anand, Paras K and Bertin, John and Green, Douglas R and Lamkanfi, Mohamed and Kanneganti, Thirumala-Devi},
  issn         = {1535-6108},
  journal      = {CANCER CELL},
  keyword      = {PROTEIN,SUSCEPTIBILITY,MICE,ACTIVATION,CUTTING EDGE,ULCERATIVE-COLITIS,BOWEL-DISEASE,COLORECTAL-CANCER,NF-KAPPA-B,CROHNS-DISEASE},
  language     = {eng},
  number       = {5},
  pages        = {649--660},
  title        = {The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis},
  url          = {http://dx.doi.org/10.1016/j.ccr.2011.10.022},
  volume       = {20},
  year         = {2011},
}

Chicago
Zaki, Md Hasan, Peter Vogel, RK Subbarao Malireddi, Mathilde Body-Malapel, Paras K Anand, John Bertin, Douglas R Green, Mohamed Lamkanfi, and Thirumala-Devi Kanneganti. 2011. “The NOD-like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis.” Cancer Cell 20 (5): 649–660.
APA
Zaki, Md Hasan, Vogel, P., Malireddi, R. S., Body-Malapel, M., Anand, P. K., Bertin, J., Green, D. R., et al. (2011). The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. CANCER CELL, 20(5), 649–660.
Vancouver
1.
Zaki MH, Vogel P, Malireddi RS, Body-Malapel M, Anand PK, Bertin J, et al. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. CANCER CELL. 2011;20(5):649–60.
MLA
Zaki, Md Hasan, Peter Vogel, RK Subbarao Malireddi, et al. “The NOD-like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis.” CANCER CELL 20.5 (2011): 649–660. Print.