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A colourful way to unravel the important fluidization-related granule size effect on semi-continuous drying
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Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics
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- Conference Paper
- C3
- open access
Two-dimensional granule property measurement using hyperspectral imaging in continuous pharmaceutical wet granulation
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An extended 3-compartment model for describing step change experiments in pharmaceutical twin-screw feeders at different refill regimes
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- Conference Paper
- C3
- open access
Model-based determination of spatial heterogeneities in a pharmaceutical fluidization process and integration into a mechanistic multi-level drying model
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Two-dimensional population balance model for twin-screw wet granulation : model development and calibration based on particle size distribution and porosity
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In-depth analysis of the impacts of material properties on size distributions in continuous twin-screw wet granulation to construct a generic 1D population balance model
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Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition
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Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally disintegrating tablets
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The impact of formulation composition and process settings of traditional batch versus continuous freeze-drying on protein aggregation
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- Journal Article
- A1
- open access
In-situ X-ray imaging of sublimating spin-frozen solutions
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Viscosity of API/fatty acid suspensions : pitfalls during analysis
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Screening of pharmaceutical polymers for Extrusion-Based Additive Manufacturing of patient-tailored tablets
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Prilling of API/fatty acid suspensions : screening of additives for drug release modification
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Continuous twin screw granulation : a complex interplay between formulation properties, process settings and screw design
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Continuous twin screw granulation : impact of binder addition method and surfactants on granulation of a high-dosed, poorly soluble API
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New advances in the characterization of lyophilised orally disintegrating tablets
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- Journal Article
- A1
- open access
Predicting pharmaceutical particle size distributions using kernel mean embedding
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- Journal Article
- A1
- open access
Model-based optimisation and control strategy for the primary drying phase of a lyophilisation process
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Continuous twin screw granulation : influence of process and formulation variables on granule quality attributes of model formulations
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Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment
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Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate
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Managing API raw material variability during continuous twin-screw wet granulation
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Two-compartment modeling and dynamics of top-sprayed fluidized bed granulator
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- Journal Article
- A1
- open access
A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties
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Process control levels for continuous pharmaceutical tablet manufacturing
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Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding
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Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement
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Managing API raw material variability in a continuous manufacturing line : prediction of process robustness
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Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press
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Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept : determination of the optimal dynamic infrared heater temperature during primary drying
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Continuous manufacturing of a pharmaceutical cream : investigating continuous powder dispersing and residence time distribution (RTD)
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Towards a generic model for twin-screw wet granulation
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- Journal Article
- A1
- open access
Dynamic flowsheet model development and sensitivity analysis of a continuous pharmaceutical tablet manufacturing process using the wet granulation route
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On the modelling of granule size distributions in twin-screw wet granulation : calibration of a novel compartmental population balance model
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Native starch as in situ binder for continuous twin screw wet granulation
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Heat transfer evaluation during twin-screw wet granulation in view of detailed process understanding
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Kernel mean embedding of distributions : a new data-driven model approach for modelling a continuous pharmaceutical twin-screw granulation process
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Population balance modelling for twin-screw wet granulation : insight in the notion of distance between distributions and the need for identifiable models for good model predictive power
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Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-speed rotary tablet press
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Downscaling of the tableting process : feasibility of miniaturized forced feeders on a high-speed rotary tablet press
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The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses
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- Conference Paper
- C3
- open access
A model predictive control strategy of the dynamic primary drying settings for a batch freeze drying process
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- Journal Article
- A1
- open access
Impact of blend properties on die filling during tableting
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- Journal Article
- A1
- open access
Thermal imaging as a noncontact inline process analytical tool for product temperature monitoring during continuous freeze-drying of unit doses
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- Journal Article
- A1
- open access
A novel approach to support formulation design on twin screw wet granulation technology : understanding the impact of overarching excipient properties on drug product quality attributes
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- Journal Article
- A1
- open access
Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets
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Raw material variability of an active pharmaceutical ingredient and its relevance for processability in secondary continuous pharmaceutical manufacturing
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Breakage and drying behaviour of granules in a continuous fluid bed dryer : influence of process parameters and wet granule transfer
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Model development and prediction of particle size distribution, density and friability of a comilling operation in a continuous pharmaceutical manufacturing process