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- 2017
- In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions
- Statistical process control of cocrystallization processes : a comparison between OPLS and PLS
- Continuous direct compression as manufacturing platform for sustained release tablets
- The use of partially hydrolysed polyvinyl alcohol for the production of high drug-loaded sustained release pellets via extrusion-spheronisation and coating : in vitro and in vivo evaluation
- In vitro and ex vivo delivery of tailored siRNA-nanoliposomes for E2F1 silencing as a potential therapy for colorectal cancer
- Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process
- Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses
- Cytotoxicity of polycations : relationship of molecular weight and the hydrolytic theory of the mechanism of toxicity
- Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses
- Elucidation and visualization of solid-state transformation and mixing in a pharmaceutical mini hot melt extrusion process using in-line Raman spectroscopy
- In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding
- Downstream processing from hot-melt extrusion towards tablets: A quality by design approach
- 2016
- An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis
- Continuous manufacturing of delta mannitol by cospray drying with PVP
- A comparative study between melt granulation/compression and hot melt extrusion/injection molding for the manufacturing of oral sustained release thermoplastic polyurethane matrices
- Biocompatible Zr-based nanoscale MOFs coated with modified poly (ε-caprolactone) as anticancer drug carriers
- Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding
- The impact of hot-melt extrusion on the tableting behaviour of polyvinyl alcohol
- Improved tabletability after a polymorphic transition of delta-mannitol during twin screw granulation
- Continuous twin screw granulation of controlled release formulations with various HPMC grades
- The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation
- 2015
- Enteric protection of naproxen in a fixed-dose combination product produced by hot-melt co-extrusion
- Enniatin-containing solutions for oromucosal use: quality-by-design ex-vivo transmucosal risk assessment of composition variability
- Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications
- Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation
- In-line near infrared spectroscopy during freeze-drying as a tool to measure efficiency of hydrogen bond formation between protein and sugar, predictive of protein storage stability
- Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses
- 2014
- Experimental investigation of granule size and shape dynamics in twin-screw granulation
- Dry heat forced degradation of buserelin peptide: kinetics and degradant profiling
- Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers: a case study with diprophylline
- The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria
- Distribution of binder in granules produced by means of twin screw granulation
- Hot-melt co-extrusion for the production of fixed-dose combination products with a controlled release ethylcellulose matrix core
- 2013
- Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions
- 2012
- Systematic evaluations regarding interparticular mass transfer in spheronization
- Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations
- Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules
- Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging
- 2011
- Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes
- 2010
- Synergistic effects between natural histone mixtures and polyethylenimine in non-viral gene delivery in vitro
- Taste-masked quinine pamoate tablets for treatment of children with uncomplicated Plasmodium falciparum malaria
- 2009
- In vitro cytotoxicity of paclitaxel/β-cyclodextrin complexes for HIPEC
- Influence of heat treatment on spray-dried mixtures of Amioca (R) starch and Carbopol (R) 974P used as carriers for nasal drug delivery
- Effect on the nasal bioavailability of co-processing drug and bioadhesive carrier via spray-drying
- Development of fixed dose combination tablets containing zidovudine and lamivudine for paediatric applications
- 2008
- Validation of a continuous granulation process using a twin-screw extruder
- Screening poly(ethyleneglycol) micro- and nanogels for drug delivery purposes
- 2007
- Influence of free chains on the swelling pressure of PEG-HEMA and dex-HEMA hydrogels
- Cell uptake, cytoplasmic diffusion and nuclear access of a 6.5 nm diameter dendrimer
- 2006
- Melt granulation using a twin-screw extruder: A case study
- Influence of deposition and spray pattern of nasal powders on insulin bioavailability
- The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying
- Characterization of diffusion of macromolecules in konjac glucomannan solutions and gels by fluorescence recovery after photobleaching technique
- 2005
- In vitro evaluation of coating polymers for enteric coating and human ileal targeting
- Spray-dried Amioca (R) starch/Carbopol (R) 974P mixtures as buccal bioadhesive carriers
- 2004
- Bioavailability of ibuprofen from hot-melt extruded mini-matrices
- Polymeric prodrugs
- Twin screw granulation as a simple and efficient tool for continuous wet granulation
- Similarity approach to QSAR - Application to antimycobacterial benzoxazines
- 2003
- Using deepest regression method for optimization of fluidized bed granulation on semi-full scale
- Influence of multiple nasal administrations of bioadhesive powders on the insulin bioavailability
- 2002
- A comparison between the use of dynamic mechanical analysis and oscillatory shear rheometry for the characterisation of hydrogels.
- Direct compression properties of melt-extruded isomalt.
- Direct compression and moulding properties of co-extruded isomalt/drug mixtures.
- In vivo evaluation of matrix pellets containing nanocrystalline ketoprofen.
- Continuous twin screw extrusion for the wet granulation of lactose.
- Principal component analysis of dissolution data with missing elements.
- Bioavailability of hydrochlorothiazide from isomalt-based moulded tablets.
- 2001
- An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen.
- Characterisation and disintegration properties of irradiated starch.
- Evaluation of dissolution profiles using principal component analysis
- 2000
- Matrix mini-tablets based on starch/microcrystalline wax mixtures.
- Variability in lung deposition of inhaled drug, within and between asthmatic patients, with a pMDI and a dry powder inhaler, Turbuhaler (R)
- Bioavailability of ibuprofen from matrix mini-tablets based on a mixture of starch and microcrystalline wax.
- 1999
- Bioavailability of starch based hot stage extrusion formulations.
- Compatibility and stability of ternary admixtures of morphine with haloperidol or midazolam and dexamethasone or methylprednisolone.
- Preparation and in vitro characterization of HSA-mPEG nanoparticles.
- Influence of the formulation composition on the in vitro characteristics of hot stage extrudates.
- Stability and compatibility of morphine.
- Influence of the process parameters on the characteristics of starch based hot stage extrudates.
- The formulation and stability of erythromycin benzoyl peroxide in a topical gel.
- Characterization and Evaluation of Isolmalt Performance in Direct Compression.
- 1998
- Formulation of a lyophilized dry emulsion tablet for the delivery of poorly soluble drugs.
- Compatibility and stability of morphine in binary admixtures with haloperidol, midazolam, dexamethasone or methylprednisolone.
- Evaluation of substrate-binder interaction in a model granule system.
- Reducing dust and improving granule and tablet quality in the roller compaction process.
- Bioavailability of hydrochlorothiazide: Conventional versus freeze-dried tablets.
- Roller compaction and tableting of microcrystalline cellulose drug mixtures.
- The roller compaction of different types of lactose.
- Bioavailability of ibuprofen from matrix pellets based on the combination of waxes and starch derivatives.
- 1997
- Instrumentation of a roll compactor and the evaluation of the parameter settings by neural networks.
- Formulation and production of rapidly disintegrating tablets by lyophilisation using hydrochlorothiazide as a model drug.
- The solubility of morphine and the stability of concentrated morphine solutions in glass, polypropylene syringes and PVC containers.
- Moisture absorption and desorption of different rubber lyophilisation closures.
- Influence of processing on the characteristics of matrix pellets based on microcrystalline waxes and starch derivatives.
- Optimisation of electrical conductance measurements for the quantification and prediction of phase separation in o/w-emulsions, containing hydroxypropylmethylcelluloses as emulsifying agents.
- Stabilization of fully active chymopapain by lyophilization.
- 1996
- In vitro and in vivo evaluation of a xanthan gum-n-octenylsuccinate starch matrix tablet containing ibuprofen as a model drug.
- Stabilisation of suspensions using sucrose esters and low substituted n-octenylsuccinate starch-xanthan gum associations.
- Influence of impeller design, method of screen perforation and perforation geometry on the quality of pellets made by extrusion-spheronisation.
- Influence of the buccal application site of a bioadhesive slow-release tablet on salivary miconazole concentrations in irradiated patients.
- Validation of filter sterilisation in autoclaves.
- Matrix pellets based on the combination of waxes, starches and maltodextrins.
- 1995
- Microcrystalline cellulose-sucrose esters as tablet matrix forming agents.
- Extrusion-spheronisation - A literature-review.
- ALGINATES AS DRUG CARRIERS - COVALENT ATTACHMENT OF ALGINATES TO THERAPEUTIC AGENTS CONTAINING PRIMARY AMINE GROUPS.
- 1994
- Study of the bioavailability of gour indomathacin suppository formulations in healthy-volunteers.
- The influence of the extrusion screen on pellet quality using an instrumented basket extruder.
- The influence of formulation on the relative bioavailability of indomethacin suppositories in dogs and rabbits.
- Phospholipid-omposition of r-DNA hepatitis-B surface-antigens.
- PARAMETERS INFLUENCING GRANULE QUALITY USING A CONTINUOUS GRANULATOR.
- Enhancement of in-vitro drug release using PEG 400 and PEG 40 hydrogenated castor-oil in pellets made by extrusion/speronisation.
- 1993
- STUDY OF PARAMETERS IMPORTANT IN THE SPHERONIZATION PROCESS.
- ENHANCEMENT OF DISSOLUTION RATE OF NIFEDIPINE USING SUCROSE ESTER COPRECIPITATES.
- Low substituted N-Octenylsuccinate starch as dissolution rate enhancer in solid dosage forms.
- INFLUENCE OF AMOUNT OF GRANULATION LIQUID ON THE DRUG-RELEASE RATE FROM PELLETS MADE BY EXTRUSION SPHERONIZATION.
- Water-vapour premeation of aqueous based ethylacrylate methylmethacry-late copolymer films.
- COMPARISON BETWEEN A GRAVITY FEED EXTRUDER AND A TWIN-SCREW EXTRUDER.
- 1992
- A COMPARISON BETWEEN THE EXTRUSION FORCES AND SPHERE QUALITY OF A GRAVITY FEED EXTRUDER AND A RAM EXTRUDER.
- INVITRO EVALUATION OF MUCOADHESIVE PROPERTIES OF CHITOSAN AND SOME OTHER NATURAL POLYMERS.
- INFLUENCE OF FAT COMPOSITION ON THE MELTING BEHAVIOR AND ON THE INVITRO RELEASE OF INDOMETHACIN SUPPOSITORIES.