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Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection
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NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes
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Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax
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Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes
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Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice
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DNGR1-Cre-mediated deletion of Tnfaip3/A20 in conventional dendritic cells induces pulmonary hypertension in mice
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Zeb2 drives invasive and microbiota-dependent colon carcinoma
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Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation
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DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology
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TNF-α-induced protein 3 levels in lung dendritic cells instruct TH2 or TH17 cell differentiation in eosinophilic or neutrophilic asthma
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Identification of immune-responsive gene 1 (IRG1) as a target of A20
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A20 inhibits β-cell apoptosis by multiple mechanisms and predicts residual β-cell function in type 1 diabetes
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Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling
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A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death
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Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis
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Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice