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Therapeutic modulation of inflammasome pathways
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Pyroptosis
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Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
(2015) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112(5). p.1541-1546 -
FADD and Caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes
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Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation
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A novel caspase-2 complex containing TRAF2 and RIP1