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T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
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- Journal Article
- A1
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Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly
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Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development
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- Journal Article
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Nanobody based dual specific CARs
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- Journal Article
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Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
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- Journal Article
- A1
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Notch3 activation is sufficient but not required for inducing human T-lineage specification
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Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
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Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions
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An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells