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Dual-acting small molecules : subtype-selective cannabinoid receptor 2 agonist/butyrylcholinesterase inhibitor hybrids show neuroprotection in an Alzheimer's disease mouse model
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A phloem‐localized Arabidopsis metacaspase (AtMC3) improves drought tolerance
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Death by TNF : a road to inflammation
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From PERK to RIPK1 : design, synthesis and evaluation of novel potent and selective necroptosis inhibitors
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Mechanisms controlling plant proteases and their substrates
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High-throughput mechano-cytometry as a method to detect apoptosis, necroptosis, and ferroptosis
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Functions of the RIP kinase family members in the skin
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The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments
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Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors
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Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
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Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers
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Investigation of Fas (APO-1)-related apoptosis in piglets intradermally or intramuscularly vaccinated with a commercial PRRSV MLV
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Effects of modulated electro-hyperthermia (mEHT) on two and three year survival of locally advanced cervical cancer patients
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A multi-omics study to boost continuous bolaform sophorolipid production
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The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach
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Estrogen receptor 8 activation inhibits colitis by promoting NLRP6-mediated autophagy
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Cytotoxic effects of alternariol, alternariol monomethyl-ether, and tenuazonic acid and their relevant combined mixtures on human enterocytes and hepatocytes
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Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis
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Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis
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One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer
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Insights into the genetics of the Zhonghua 11 resistance to Meloidogyne graminicola and its molecular determinism in rice
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Phenology-regulated defence mechanisms as drivers for Fusarium basal rot in onion (Allium cepa)
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Predicting the hydrodynamic properties of a bioreactor : conditional density estimation as a surrogate model for CFD simulations
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The human inflammasomes
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At the crossroads of survival and death : the reactive oxygen species-ethylene-sugar triad and the unfolded protein response
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Pathogens pulling the strings : effectors manipulating salicylic acid and phenylpropanoid biosynthesis in plants
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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The utility of biomarkers in prognosis assessment of patients with acute liver failure
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Conditional destabilization of the TPLATE complex impairs endocytic internalization
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Neutrophil extracellular traps in cattle health and disease
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Deep learning with digital holographic microscopy discriminates apoptosis and necroptosis
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Necroptosis signalling promotes inflammation, airway remodelling and emphysema in COPD
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MLKL in cancer : more than a necroptosis regulator
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Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis
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Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor
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Gastric Helicobacter suis infection partially protects against neurotoxicity in A 6-OHDA Parkinson’s disease mouse model
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Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner
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Curcumin-1,2,3-Triazole Conjugation for Targeting the Cancer Apoptosis Machinery
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Chemical genetics approach identifies abnormal inflorescence meristem 1 as a putative target of a novel sulfonamide that protects catalase2-deficient Arabidopsis against photorespiratory stress
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Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation
(2020) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117(33). p.19982-19993 -
RIPK1 kinase-dependent death : a symphony of phosphorylation events
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Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
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Novel role of JAC1 in influencing photosynthesis, stomatal conductance, and photooxidative stress signalling pathway in Arabidopsis thaliana
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Cancer therapy with iron oxide nanoparticles : agents of thermal and immune therapies
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Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy
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Recent insights on inflammasomes, gasdermin pores, and pyroptosis
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Therapeutic modulation of inflammasome pathways
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gamma-Aminobutyric acid and related amino acids in plant immune responses : emerging mechanisms of action
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Inhibitors targeting RIPK1/RIPK3 : old and new drugs
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Ferroptosis : biological rust of lipid membranes
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Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex
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Enhancement of biomimetic enzymatic mineralization of gellan gum polysaccharide hydrogels by plant-derived gallotannins
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Vitamin C controls neuronal necroptosis under oxidative stress
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On the move : redox-dependent protein relocation in plants
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Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock
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Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function
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Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
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A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain
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Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration
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Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy
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To NET or not to NET : current opinions and state of the science regarding the formation of neutrophil extracellular traps
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Functional analysis of Arabidopsis and maize transgenic lines overexpressing the ADP-ribose/NADH pyrophosphohydrolase, AtNUDX7
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Characterization of the γ-secretase subunit interactome in Arabidopsis thaliana
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Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis
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Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids
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Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis
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Extracellular neutrophil proteases are efficient regulators of IL-1, IL-33, and IL-36 cytokine activity but poor effectors of microbial killing
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The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling
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Peanut stunt virus and its satellite RNA trigger changes in phosphorylation in N-benthamiana infected plants at the early stage of the infection
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Discovery of novel, drug-like ferroptosis inhibitors with in vivo efficacy
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Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis
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Therapeutic targeting of connexin channels : new views and challenges
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Loss of nuclear envelope integrity in aging and disease
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MK2 puts an additional brake on RIPK1 cytotoxic potential
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Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2
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Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
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Biochanin a enhances the defense against Salmonella enterica infection through AMPK/ULK1/mTOR-mediated autophagy and extracellular traps and reversing SPI-1-dependent macrophage (MΦ) M2 polarization
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Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines
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Necroptosis : (last) message in a bubble
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Heavy metal suicide
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Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis
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Effect of starvation and refeeding on the ultrastructure of the perigastric organ (hepatopancreas) in the whiteleg shrimp Litopenaeus vannamei (Boone, 1931) (Decapoda: Caridea: Penaeidae)
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When PERK inhibitors turn out to be new potent RIPK1 inhibitors : critical issues on the specificity and use of GSK2606414 and GSK2656157
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Coating of quantum dots strongly defines their effect on lysosomal health and autophagy
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Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice
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The inflammasome turns 15
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Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome
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The use of diatoms in ecotoxicology and bioassessment : insights, advances and challenges
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Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
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Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication
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Structural characterization of a lectin from Canavalia virosa seeds with inflammatory and cytotoxic activities
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Interaction between hormonal and mitochondrial signalling during growth, development and in plant defence responses
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CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3
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Novel ferroptosis inhibitors with improved potency and ADME properties
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Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice
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More to life than NF-κB in TNFR1 signaling
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Lack of GLYCOLATE OXIDASE1, but not GLYCOLATE OXIDASE2, attenuates the photorespiratory phenotype of CATALASE2-deficient Arabidopsis
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Overexpression of glucocorticoid-induced leucine zipper (GILZ) increases susceptibility to imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1
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NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice
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Fractionated radiotherapy with 3 x 8 Gy induces systemic anti-tumour responses and abscopal tumour inhibition without modulating the humoral anti-tumour response