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Event-based PID control for anesthesia administration : effect on hemodynamic variables
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- Journal Article
- A1
- open access
Bayesian statistics in anesthesia practice : a tutorial for anesthesiologists
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- Journal Article
- A1
- open access
Comparison of haemodynamic- and electroencephalographic-monitored effects evoked by four combinations of effect-site concentrations of propofol and remifentanil, yielding a predicted tolerance to laryngoscopy of 90%
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Influence of an "electroencephalogram-based" monitor choice on the delay between the predicted propofol effect-site concentration and the measured drug effect
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- Journal Article
- A1
- open access
Closed-loop control of anesthesia : survey on actual trends, challenges and perspectives
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Autonomous systems in anesthesia : where do we stand in 2020? A narrative review
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Population pharmacodynamics of propofol and sevoflurane in healthy volunteers using a clinical score and the patient state index : a crossover study
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Pharmacodynamic interaction of remifentanil and dexmedetomidine on depth of sedation and tolerance of laryngoscopy
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Novel drug-independent sedation level estimation based on machine learning of quantitative frontal electroencephalogram features in healthy volunteers
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- Journal Article
- A1
- open access
A comparison of propofol-to-BIS post-operative intensive care sedation by means of target controlled infusion, Bayesian-based and predictive control methods : an observational, open-label pilot study
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Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation
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Test of neural inertia in humans during general anaesthesia
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- Journal Article
- A1
- open access
Clinical pharmacokinetics and pharmacodynamics of propofol
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Tracking electroencephalographic changes using distributions of linear models : application to propofol-vased depth of anesthesia monitoring
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Pharmacokinetic and pharmacodynamic interactions in anaesthesia : a review of current knowledge and how it can be used to optimize anaesthetic drug administration
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Probability to tolerate laryngoscopy and noxious stimulation response index as general indicators of the anaesthetic potency of sevoflurane, propofol, and remifentanil
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Comparisons of electroencephalographically derived measures of hypnosis and antinociception in response to standardized stimuli during target-controlled propofol-remifentanil anesthesia
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Inversion-based propofol dosing for intravenous induction of hypnosis
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Model-based drug administration: current status of target-controlled infusion and closed-loop control
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The history of target-controlled infusion
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- Journal Article
- A1
- open access
Advanced model-based control studies for the induction and maintenance of intravenous anaesthesia
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Nonlinear dynamics of the patient's response to drug effect during general anesthesia
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Estimation of patient sensitivity to drug effect during Propofol hypnosis
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- Journal Article
- A1
- open access
A response surface model approach for continuous measures of hypnotic and analgesic effect during sevoflurane-remifentanil interaction: quantifying the pharmacodynamic shift evoked by stimulation
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Bispectral index values and propofol concentrations at loss and return of consciousness in patients with frontal brain tumours and control patients
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Lessons learned from closed loops in engineering: towards a multivariable approach regulating depth of anaesthesia
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Accuracy of the composite variability index as a measure of the balance between nociception and, antinociception during anesthesia
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A general purpose pharmacokinetic model for propofol
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Drug delivery system for general anesthesia: where are we?
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Non-invasive methods applied for complex signals
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Optimizing intravenous drug administration by applying pharmacokinetic/pharmacodynamic concepts
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Closed loop anesthesia: are we getting close to finding the Holy Grail?
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Robustness tests of a model based predictive control strategy for depth of anesthesia regulation in a propofol to bispectral index framework
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Evaluation of a propofol and remifentanil interaction model for predictive control of anesthesia induction
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Noxious stimulation response index: a novel anesthetic state index based on hypnotic-opioid interaction
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Propofol and Remifentanil differentially modulate frontal electroencephalographic activity
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Assessment of the depth of anesthesia based on symbolic dynamics of the EEG
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EPSAC-controlled anesthesia with online gain adaptation
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Comparison of contemporary EEG derived depth of anesthesia monitors with a 5 step validation process
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- Conference Paper
- C3
- open access
Comparing index of consciousness and bispectral index during propofol recovery
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Robust predictive control strategy applied for propofol dosing using BIS as a controlled variable during anesthesia
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- Journal Article
- A1
- open access
Simulated drug administration: An emerging tool for teaching clinical pharmacology during anesthesiology training
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Changes in a surgical stress index in response to standardized pain stimuli during propofol-remifentanil infusion
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Multi-level approach to anaesthetic effects produced by sevoflurane or propofol in humans, 1: BIS and blink reflex
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Multi-level approach to anaesthetic effects produced by sevoflurane or propofol in humans, 2: BIS and tetanic stimulus-induced withdrawal reflex
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Feasibility study for the administration of remifentanil based on the difference between response entropy and state entropy
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Effect site: who needs it?
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Do we need inhaled anaesthetics to blunt arousal, haemodynamic responses to intubation after i.v. induction with propofol, remifentanil, rocuronium?
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Cerebral state index during propofol anesthesia : a comparison with the bispectral index and the A-line ARX index
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Depth of anaesthesia monitoring: what's available, what's validated and what's next?