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- 2016
- Rationale and safety assessment of a novel intravaginal drug-delivery system with sustained DL-lactic acid release, intended for long-term protection of the vaginal microbiome
- pH-independent immediate release polymethacrylate formulations: an observational study
- Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding
- 2015
- Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press
- Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance
- Use of a continuous twin screw granulation and drying system during formulation development and process optimization
- Fatty acids for controlled release applications: a comparison between prilling and solid lipid extrusion as manufacturing techniques
- Process analytical technology for continuous manufacturing of solid-dosage forms
- Comparison of Newcastle disease vaccine administered as powder or liquid in relation to the serum antibody response and adverse vaccinal reactions in broilers
- Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding
- Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation
- Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation
- Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion
- Combined experimental and computational approach to elucidate the twin-screw granulation process
- Enteric protection of naproxen in a fixed-dose combination product produced by hot-melt co-extrusion
- Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications
- Freeze-drying of live virus vaccines: a review
- FTIR spectroscopy for the detection and evaluation of live attenuated viruses in freeze dried vaccine formulations
- 2014
- A model based analysis of IPEC dosing of paclitaxel in rats
- Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets
- Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers: a case study with diprophylline
- Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models
- Effects of hyperthermia versus drug dose on toxicity and pharmacodynamics of oxaliplatin-based intraoperative chemoperfusion: results of a phase II trial
- In-line solid state prediction during pharmaceutical hot-melt extrusion in a 12 mm twin screw extruder using Raman spectroscopy
- Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs
- Distribution of binder in granules produced by means of twin screw granulation
- Hot-melt co-extrusion for the production of fixed-dose combination products with a controlled release ethylcellulose matrix core
- Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules
- Mixing and transport during pharmaceutical twin-screw wet granulation: experimental analysis via chemical imaging
- Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations
- Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications
- Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging
- Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion
- Experimental investigation of granule size and shape dynamics in twin-screw granulation
- Process monitoring and visualization solutions for hot-melt extrusion: a review
- Crystal coating via spray drying to improve powder tabletability
- Co-extruded solid solutions as immediate release fixed-dose combinations
- 2013
- Real-time assessment of critical quality attributes of a continuous granulation process
- Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations
- Stability and repeatability of a continuous twin screw granulation and drying system
- Co-extrusion as manufacturing technique for multilayer mini-matrices with dual drug release
- Vaginal distribution and retention of tablets comprising starch-based multiparticulates: evaluation by colposcopy
- Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms
- Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: a review
- Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy
- Formulation of poorly water-soluble drugs via coacervation: a pilot study using febantel
- Solvent-free drug crystal engineering for drug nano- and micro suspensions
- Particle sizing measurements in pharmaceutical applications: comparison of in-process methods versus off-line methods
- Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent
- Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs
- Structural modifications of polymethacrylates: impact on thermal behavior and release characteristics of glassy solid solutions
- Near-infrared spectroscopic evaluation of lyophilized viral vaccine formulations
- 2012
- Continuous twin screw granulation: influence of process variables on granule and tablet quality
- Near-infrared spectroscopy for in-line monitoring of protein unfolding and its interactions with lyoprotectants during freeze-drying
- Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules
- Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging
- Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices
- In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion
- Interaction between polymeric multilayer capsules and immune cells
- Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection
- Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function
- Development of a fluid bed granulation process control strategy based on real-time process and product measurements
- Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding
- Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1
- Hot-melt extrusion developments in the pharmaceutical industry
- Mechanistic modelling of the drying behaviour of single pharmaceutical granules
- Poly(2-ethyl-2-oxazoline) as matrix excipient for drug formulation by hot melt extrusion and injection molding
- Sustained release from hot-melt extruded matrices based on ethylene vinyl acetate and polyethylene oxide
- Engineered 3D microporous gelatin scaffolds to study cell migration
- Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry
- Prediction of quality attributes of continuously produced granules using complementary pat tools
- Development of a nanocrystalline Paclitaxel formulation for HIPEC treatment
- Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations
- 2011
- Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation
- Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes
- Mechanistic modelling of fluidized bed drying processes of wet porous granules: a review
- Chiral inversion of R(-) to S(+) ketoprofen in pigs
- The adjuvant effect of Gantrez®AN nanoparticles on oral vaccination of pigs and mice with F4 fimbriae is strongly influenced by polymer degradation
- Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process
- Mucosal irritation potential of polyelectrolyte multilayer capsules
- Feasibility of the Ussing chamber technique for the determination of in vitro jejunal permeability of passively absorbed compounds in different animal species
- Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen
- Modelling of drying processes of pharmaceutical granules
- Modelling of drying processes of pharmaceutical granules
- Adjuvant effect of Gantrez®AN nanoparticles during oral vaccination of piglets against F4+enterotoxigenic Escherichia coli
- Batch statistical process control of a fluid bed granulation process using in-line spatial filter velocimetry and product temperature measurements
- Influence of polymer hydrolysis on adjuvant effect of Gantrez®AN nanoparticles: implications for oral vaccination
- Real-time image-based investigation of spheronization and drying phenomena using different pellet formulations
- Polymeric multilayer capsules delivering biotherapeutics
- Designing polymeric particles for antigen delivery
- Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion
- Single-step formation of degradable intracellular biomolecule microreactors
- Antitumour efficacy of two paclitaxel formulations for hyperthermic intraperitoneal chemotherapy (HIPEC) in an in vivo rat model
- Optimization of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analyzers
- 2010
- Aminopeptidase N as a target for oral vaccine delivery
- Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants
- Layer-by-layer incorporation of growth factors in decellularized aortic heart valve leaflets
- A batch modelling approach to monitor a freeze-drying process using in-line Raman spectroscopy
- In vitro evaluation of gentamicin- and vancomycin-containing minitablets as a replacement for fortified eye drops
- A single step process for the synthesis of antigen laden thermosensitive microparticles