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- 2014
- A model based analysis of IPEC dosing of paclitaxel in rats
- Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models
- Effects of hyperthermia versus drug dose on toxicity and pharmacodynamics of oxaliplatin-based intraoperative chemoperfusion: results of a phase II trial
- Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules
- Mixing and transport during pharmaceutical twin-screw wet granulation: experimental analysis via chemical imaging
- Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications
- Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging
- Process monitoring and visualization solutions for hot-melt extrusion: a review
- 2013
- Stability and repeatability of a continuous twin screw granulation and drying system
- Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations
- Co-extrusion as manufacturing technique for multilayer mini-matrices with dual drug release
- Real-time assessment of critical quality attributes of a continuous granulation process
- Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent
- Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs
- Near-infrared spectroscopic evaluation of lyophilized viral vaccine formulations
- Structural modifications of polymethacrylates: impact on thermal behavior and release characteristics of glassy solid solutions
- Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms
- Vaginal distribution and retention of tablets comprising starch-based multiparticulates: evaluation by colposcopy
- Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy
- Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: a review
- Formulation of poorly water-soluble drugs via coacervation: a pilot study using febantel
- Solvent-free drug crystal engineering for drug nano- and micro suspensions
- Particle sizing measurements in pharmaceutical applications: comparison of in-process methods versus off-line methods
- 2012
- Continuous twin screw granulation: influence of process variables on granule and tablet quality
- Near-infrared spectroscopy for in-line monitoring of protein unfolding and its interactions with lyoprotectants during freeze-drying
- Prediction of quality attributes of continuously produced granules using complementary pat tools
- Sustained release from hot-melt extruded matrices based on ethylene vinyl acetate and polyethylene oxide
- Poly(2-ethyl-2-oxazoline) as matrix excipient for drug formulation by hot melt extrusion and injection molding
- Development of a nanocrystalline Paclitaxel formulation for HIPEC treatment
- Engineered 3D microporous gelatin scaffolds to study cell migration
- Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry
- Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations
- In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion
- Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices
- Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules
- Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging
- Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding
- Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection
- Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function
- Development of a fluid bed granulation process control strategy based on real-time process and product measurements
- Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1
- Hot-melt extrusion developments in the pharmaceutical industry
- Mechanistic modelling of the drying behaviour of single pharmaceutical granules
- 2011
- Chiral inversion of R(-) to S(+) ketoprofen in pigs
- Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes
- Mechanistic modelling of fluidized bed drying processes of wet porous granules: a review
- Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation
- Designing polymeric particles for antigen delivery
- Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion
- Single-step formation of degradable intracellular biomolecule microreactors
- Antitumour efficacy of two paclitaxel formulations for hyperthermic intraperitoneal chemotherapy (HIPEC) in an in vivo rat model
- Optimization of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analyzers
- The adjuvant effect of Gantrez®AN nanoparticles on oral vaccination of pigs and mice with F4 fimbriae is strongly influenced by polymer degradation
- Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process
- Mucosal irritation potential of polyelectrolyte multilayer capsules
- Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen
- Feasibility of the Ussing chamber technique for the determination of in vitro jejunal permeability of passively absorbed compounds in different animal species
- Modelling of drying processes of pharmaceutical granules
- Modelling of drying processes of pharmaceutical granules
- Adjuvant effect of Gantrez®AN nanoparticles during oral vaccination of piglets against F4+enterotoxigenic Escherichia coli
- Polymeric multilayer capsules delivering biotherapeutics
- Batch statistical process control of a fluid bed granulation process using in-line spatial filter velocimetry and product temperature measurements
- Influence of polymer hydrolysis on adjuvant effect of Gantrez®AN nanoparticles: implications for oral vaccination
- Real-time image-based investigation of spheronization and drying phenomena using different pellet formulations
- 2010
- Aminopeptidase N as a target for oral vaccine delivery
- Layer-by-layer incorporation of growth factors in decellularized aortic heart valve leaflets
- Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants
- Adjuvant effect of Gantrez AN nanoparticles during oral vaccination with F4 fimbriae
- Vancomycin release from poly(D,L-lactic acid) spray-coated hydroxyapatite fibers
- Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen
- Facile two-step synthesis of porous antigen-loaded degradable polyelectrolyte microspheres
- Influence of reaction medium during synthesis of Gantrez® AN 119 nanoparticles for oral vaccination
- Taste-masked quinine pamoate tablets for treatment of children with uncomplicated Plasmodium falciparum malaria
- Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation
- Controlled crystallization of the lipophilic drug fenofibrate during freeze-drying: elucidation of the mechanism by in-line Raman spectroscopy
- Influence of surface topography and pore architecture of alkali-treated titanium on in vitro apatite deposition
- In vitro evaluation of gentamicin- and vancomycin-containing minitablets as a replacement for fortified eye drops
- A single step process for the synthesis of antigen laden thermosensitive microparticles
- In vivo toxicity and bioavailability of taxol (R) and a paclitaxel/beta-cyclodextrin formulation in a rat model during HIPEC
- A batch modelling approach to monitor a freeze-drying process using in-line Raman spectroscopy
- Polymeric multilayer capsules in drug delivery
- Adjustment of dosing of antimicrobial agents for bodyweight in adults
- 2009
- A pilot study evaluating the safety of vaginal administration of a multi-particulate pellet formulation.
- Importance of using complementary process analyzers for the process monitoring, analysis, and understanding of freeze drying
- Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine
- Detection of very small density fluctuations in pharmaceutical samples by application of the Modified Bronnikov Algorithm on micro-CT data
- Interspecies comparison of oral bioavailability and jejunal permeability of paracetamol in the framework of a veterinary biopharmaceutics classification system
- Evaluation of injection moulding as a pharmaceutical technology to produce matrix tablets
- Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose
- Development of fixed dose combination tablets containing zidovudine and lamivudine for paediatric applications
- Influence of polyethylene glycol/polyethylene oxide on the release characteristics of sustained-release ethylcellulose mini-matrices produced by hot-melt extrusion: in vitro and in vivo evaluations
- Porous pellets as drug delivery system
- Safety and colonisation potential of a new multi-particulate pellet formulation for vaginal delivery of probiotic lactobacilli
- In-Line and Real-Time Process Monitoring of a Freeze Drying Process Using Raman and NIR Spectroscopy as Complementary Process Analytical Technology (PAT) Tools
- Comparison of two twin-screw extruders for continuous granulation
- Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies
- Modeling drug release from hot-melt extruded mini-matrices with constant and non-constant diffusivities
- In vivo evaluation of the vaginal distribution and retention of a multi-particulate pellet formulation
- Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: a critical review
- Effect on the nasal bioavailability of co-processing drug and bioadhesive carrier via spray-drying