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- 2017
- Pharmacokinetic analysis of modified-release metoprolol formulations : an interspecies comparison
- Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process
- Downstream processing from melt granulation towards tablets: In-depth analysis of a continuous twin-screw melt granulation process using polymeric binders
- In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions
- Continuous direct compression as manufacturing platform for sustained release tablets
- The use of partially hydrolysed polyvinyl alcohol for the production of high drug-loaded sustained release pellets via extrusion-spheronisation and coating : in vitro and in vivo evaluation
- Elucidation and visualization of solid-state transformation and mixing in a pharmaceutical mini hot melt extrusion process using in-line Raman spectroscopy
- Downstream processing from hot-melt extrusion towards tablets: A quality by design approach
- Downstream processing from hot-melt extrusion towards tablets: A quality by design approach
- 2016
- Rationale and safety assessment of a novel intravaginal drug-delivery system with sustained DL-lactic acid release, intended for long-term protection of the vaginal microbiome
- Model-based analysis of a twin-screw wet granulation system for continuous solid dosage manufacturing
- Development of a process map : a step towards a regime map for steady-state high shear wet twin screw granulation
- Improved tabletability after a polymorphic transition of delta-mannitol during twin screw granulation
- Continuous twin screw granulation of controlled release formulations with various HPMC grades
- The impact of hot-melt extrusion on the tableting behaviour of polyvinyl alcohol
- Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding
- Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press
- Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy
- The use of rheology combined with differential scanning calorimetry to elucidate the granulation mechanism of an immiscible formulation during continuous twin-screw melt granulation
- Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation : an experimental investigation
- Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions: in vitro and in vivo characterization
- Continuous manufacturing of delta mannitol by cospray drying with PVP
- A comparative study between melt granulation/compression and hot melt extrusion/injection molding for the manufacturing of oral sustained release thermoplastic polyurethane matrices
- pH-independent immediate release polymethacrylate formulations : an observational study
- The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation
- 2015
- Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses
- Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding
- Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press
- Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance
- Fatty acids for controlled release applications: a comparison between prilling and solid lipid extrusion as manufacturing techniques
- Use of a continuous twin screw granulation and drying system during formulation development and process optimization
- Process analytical technology for continuous manufacturing of solid-dosage forms
- Comparison of Newcastle disease vaccine administered as powder or liquid in relation to the serum antibody response and adverse vaccinal reactions in broilers
- Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation
- Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation
- Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion
- Enteric protection of naproxen in a fixed-dose combination product produced by hot-melt co-extrusion
- Combined experimental and computational approach to elucidate the twin-screw granulation process
- Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications
- Freeze-drying of live virus vaccines: a review
- FTIR spectroscopy for the detection and evaluation of live attenuated viruses in freeze dried vaccine formulations
- 2014
- A model based analysis of IPEC dosing of paclitaxel in rats
- Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers: a case study with diprophylline
- Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets
- Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models
- NIR spectroscopic method for the in-line moisture assessment during drying in a six-segmented fluid bed dryer of a continuous tablet production line : validation of quantifying abilities and uncertainty assessment
- Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations
- Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications
- Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging
- Process monitoring and visualization solutions for hot-melt extrusion: a review
- Experimental investigation of granule size and shape dynamics in twin-screw granulation
- Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion
- Crystal coating via spray drying to improve powder tabletability
- Co-extruded solid solutions as immediate release fixed-dose combinations
- Effects of hyperthermia versus drug dose on toxicity and pharmacodynamics of oxaliplatin-based intraoperative chemoperfusion: results of a phase II trial
- Distribution of binder in granules produced by means of twin screw granulation
- Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs
- Hot-melt co-extrusion for the production of fixed-dose combination products with a controlled release ethylcellulose matrix core
- Mixing and transport during pharmaceutical twin-screw wet granulation: experimental analysis via chemical imaging
- Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules
- In-line solid state prediction during pharmaceutical hot-melt extrusion in a 12 mm twin screw extruder using Raman spectroscopy
- 2013
- Real-time assessment of critical quality attributes of a continuous granulation process
- Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations
- Stability and repeatability of a continuous twin screw granulation and drying system
- Co-extrusion as manufacturing technique for multilayer mini-matrices with dual drug release
- Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: a review
- Formulation of poorly water-soluble drugs via coacervation : a pilot study using febantel
- Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy
- Solvent-free drug crystal engineering for drug nano- and micro suspensions
- Particle sizing measurements in pharmaceutical applications: comparison of in-process methods versus off-line methods
- Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs
- Near-infrared spectroscopic evaluation of lyophilized viral vaccine formulations
- Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent
- Structural modifications of polymethacrylates: impact on thermal behavior and release characteristics of glassy solid solutions
- Vaginal distribution and retention of tablets comprising starch-based multiparticulates: evaluation by colposcopy
- Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms
- 2012
- Continuous twin screw granulation: influence of process variables on granule and tablet quality
- Near-infrared spectroscopy for in-line monitoring of protein unfolding and its interactions with lyoprotectants during freeze-drying
- Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1
- Development of a fluid bed granulation process control strategy based on real-time process and product measurements
- Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection
- Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function
- Hot-melt extrusion developments in the pharmaceutical industry
- Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding
- Mechanistic modelling of the drying behaviour of single pharmaceutical granules
- Engineered 3D microporous gelatin scaffolds to study cell migration
- Prediction of quality attributes of continuously produced granules using complementary pat tools
- Poly(2-ethyl-2-oxazoline) as matrix excipient for drug formulation by hot melt extrusion and injection molding
- Sustained release from hot-melt extruded matrices based on ethylene vinyl acetate and polyethylene oxide
- Development of a nanocrystalline Paclitaxel formulation for HIPEC treatment
- Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry
- Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations
- Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules
- Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging
- Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices
- In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion
- Interaction between polymeric multilayer capsules and immune cells
- 2011
- Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation
- Mechanistic modelling of fluidized bed drying processes of wet porous granules: a review
- Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes