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Drugging the NLRP3 inflammasome : from signalling mechanisms to therapeutic targets
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Comment on : effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3
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- Journal Article
- A1
- open access
Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice
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GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis
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- Journal Article
- A1
- open access
Nonredundancy of IL-1 alpha and IL-1 beta is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection
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IL1 beta promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D
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- Journal Article
- A1
- open access
Therapeutic modulation of inflammasome pathways
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Snapshot of a deadly embrace : the caspase-1-GSDMD interface
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- Journal Article
- A1
- open access
MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
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- Journal Article
- A1
- open access
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation