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PBPK and its virtual populations : the impact of physiology on pediatric pharmacokinetic predictions of tramadol
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A physiologically based pharmacokinetic perspective on the clinical utility of albumin-based dose adjustments in critically ill patients
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Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound
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- PhD Thesis
- open access
Characterizing hepatic clearance in early life : PBPK as modelling tool and tramadol as guide
(2016) -
- Journal Article
- A1
- open access
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data
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Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation
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- Journal Article
- A1
- open access
Moxifloxacin dosing in post-bariatric surgery patients
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- Conference Paper
- C3
- open access
Moxifloxacin dosing in post-bariatric surgery patients: another nail in the coffin of the 'one dose fits all' paradigm
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Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use