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- Journal Article
- A1
- open access
The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research
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Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound
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- PhD Thesis
- open access
Pharmacokinetics in children with liver disease : can ex vivo obtained population-specific CYP450 characteristics bridge the knowledge gap?
(2014) -
- Journal Article
- A1
- open access
Enzymatic tumour tissue digestion coupled to SPE-UPLC–tandem mass spectrometry as a tool to explore paclitaxel tumour penetration
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In vitro cytochrome P450 activity decreases in children with high paediatric end-stage liver disease scores
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Hypervariable cytochrome P450 activity in children with severe hepatic dysfunction