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ALK positively regulates MYCN activity through repression of HBP1 expression
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A mechanistic classification of clinical phenotypes in neuroblastoma.
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Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
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- Journal Article
- A1
- open access
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
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- Journal Article
- A1
- open access
Targeting tachykinin receptors in neuroblastoma
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Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
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- Journal Article
- A1
- open access
Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
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- Journal Article
- A1
- open access
MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma
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- Journal Article
- A1
- open access
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
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Targeting MYCN-driven transcription by BET-bromodomain inhibition
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Telomerase activation by genomic rearrangements in high-risk neuroblastoma
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miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin
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Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment
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MiR-34a deficiency accelerates medulloblastoma formation in vivo
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Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma
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- Journal Article
- A1
- open access
MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosis
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MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma
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- Journal Article
- A1
- open access
Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors
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Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
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- Journal Article
- A1
- open access
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
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- Journal Article
- A1
- open access
MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation
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Mutational dynamics between primary and relapse neuroblastomas
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Early targets of miR-34a in neuroblastoma
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Genome-wide methylation analysis unravels differential DNA methylation patterns between (prognostic) neuroblastoma patient subgroups
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- Journal Article
- A1
- open access
Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling
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- Journal Article
- A1
- open access
CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients
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Reduced DICER1 functionality in neuroblastoma through reduced expression levels or somatic mutations
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Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma
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- Journal Article
- A1
- open access
Focal DNA copy number changes in neuroblastoma target MYCN regulated genes
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- Journal Article
- A1
- open access
BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
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Identifying and validating DNA methylation biomarkers: the example of neuroblastoma
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Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers
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Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers
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The MYCN driven murine and human neuroblastoma methylome and dynamic regulation of chromatin regulators as a guide for epigenetic therapy
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Genome wide expression, mutation and methylation analysis validates three new mouse models for neuroblastoma targeting MYCN, ALK and LIN28B for pre-clinical studies
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- Journal Article
- A1
- open access
MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
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Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers
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Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma
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Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas
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- Journal Article
- A1
- open access
Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers.
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
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Targeted expression of mutated ALK induces neuroblastoma in transgenic mice
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Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas
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Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation
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Promoter methylation analysis identifies prognostic methylation biomarkers in neuroblastoma
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Genomic profiling of MYCN and ALKF1174L transgenic neuroblastoma mouse models provides insights into the dynamic process of tumor formation
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MiR-137 is epigenetically silenced in MYCN amplified neuroblastomas and targets the polycomb repressive complex 2 (PRC2) component EZH2
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MiR-137 is epigenetically silenced in MYCN amplified neuroblastoma and targets the polycomb repressive complex 2 (PRC2) component EZH2
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miRNA Expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples
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High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma
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Pharmacological activation of the p53 pathway by nutlin-3 inhibits medulloblastoma cell proliferation in vitro and in vivo
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Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma
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Accurate prediction of neuroblastoma outcome based on miRNA expression profiles
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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification
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- Journal Article
- A1
- open access
Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma
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- Journal Article
- A1
- open access
The miR-17-92 MicroRNA Cluster regulates multiple components of the TGF-beta Pathway in neuroblastoma