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Systematic review and meta-analysis of genome-wide pooled CRISPR screens to identify host factors involved in influenza A virus infection.
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A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein
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- Journal Article
- A1
- open access
Epidemiology of influenza over a ten-year period in Belgium : overview of the historical and current evidence
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Development of digital droplet PCR targeting the influenza H3N2 sseltamivir-resistant E119V mutation and its performance through the use of reverse genetics mutants
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- Journal Article
- A1
- open access
Anti-neuraminidase and anti-hemagglutinin immune serum can confer inter-lineage cross protection against recent influenza B
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- Journal Article
- A1
- open access
Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity
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- Journal Article
- A1
- open access
GlycoVHH : optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery
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- Journal Article
- A1
- open access
Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
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Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair
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- Journal Article
- A1
- open access
How RSV proteins join forces to overcome the host innate immune response
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- Journal Article
- A1
- open access
Whole-genome sequence approach and phylogenomic stratification improve the association analysis of mutations with patient data in influenza surveillance
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- Journal Article
- A1
- open access
Antibodies directed towards neuraminidase restrict influenza virus replication in primary human bronchial epithelial cells
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- Journal Article
- A1
- open access
A general approach to identify low-frequency variants within influenza samples collected during routine surveillance
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- Journal Article
- A1
- open access
Pre-existing antibodies directed against a tetramerizing domain enhance the immune response against artificially stabilized soluble tetrameric influenza neuraminidase
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- Journal Article
- A1
- open access
Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity
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- Journal Article
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- open access
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection
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- Journal Article
- A1
- open access
An unexpected encounter : respiratory syncytial virus nonstructural protein 1 interacts with mediator subunit MED25
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- Journal Article
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- open access
Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies
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Cov²MS : an automated and quantitative matrix-independent assay for mass spectrometric measurement of SARS-CoV-2 nucleocapsid protein
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Single-domain antibodies make a difference
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- Journal Article
- A1
- open access
Influenza neuraminidase characteristics and potential as a vaccine target
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A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody
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- Journal Article
- A1
- open access
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
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- Journal Article
- A1
- open access
Strategy and performance evaluation of low-frequency variant calling for SARS-CoV-2 using targeted deep Illumina sequencing
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- Journal Article
- A1
- open access
In vivo therapy with M2e-specific IgG selects for an influenza A virus mutant with delayed matrix protein 2 expression
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- Journal Article
- A1
- open access
Protective efficacy of recombinant influenza hemagglutinin ectodomain fusions
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- Journal Article
- A1
- open access
Whole-genome-based phylogenomic analysis of the Belgian 2016–2017 influenza A(H3N2) outbreak season allows improved surveillance
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- Journal Article
- A1
- open access
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
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- Journal Article
- A1
- open access
An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models
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- Journal Article
- A1
- open access
Cell-mediated responses to human metapneumovirus infection
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- Journal Article
- A1
- open access
An inside job : applications of intracellular single domain antibodies
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- Journal Article
- A1
- open access
Next-generation sequencing : an eye-opener for the surveillance of antiviral resistance in influenza
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- Journal Article
- A1
- open access
Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice
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- Journal Article
- A1
- open access
The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration
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- Journal Article
- A1
- open access
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant
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Selected IL-1 activity on CD8+ T cells allows for safe enhancement of cellular immune responses
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- Journal Article
- A1
- open access
Evaluation of the protective potential of antibody and T cell responses elicited by a novel preventative vaccine towards respiratory syncytial virus small hydrophobic protein
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- Journal Article
- A1
- open access
mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice
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Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies (vol 181, pg 1004, 2020)
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Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies
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- Journal Article
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- open access
Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation
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- Journal Article
- A1
- open access
Reverse engineering synthetic antiviral amyloids
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- Journal Article
- A1
- open access
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
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- Journal Article
- A1
- open access
The role of matrix protein 2 ectodomain in the development of universal influenza vaccines
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New antibody-based prevention and treatment options for influenza
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Vaccines against human respiratory syncytial virus in clinical trials, where are we now?
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Walter Fiers (1931-2019) : obituary
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- Journal Article
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- open access
Respiratory syncytial virus nonstructural proteins 1 and 2 : exceptional disrupters of innate immune responses
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Vaccination with influenza hemagglutinin-loaded ceramic nanoporous microneedle arrays induces protective immune responses
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- Journal Article
- A1
- open access
TIV vaccination modulates host responses to influenza virus infection that correlate with protection against bacterial superinfection
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Identification of peptide domains involved in the subcellular localization of the feline coronavirus 3b protein
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Mx1 in hematopoietic cells protects against Thogoto virus infection
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A two-amino acid mutation in murine IgA enables downstream processing and purification on staphylococcal superantigen-like protein 7.
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- Journal Article
- A1
- open access
Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface
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Towards the use of interleukin-1β as vaccine adjuvant
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- Journal Article
- A1
- open access
Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice
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- Journal Article
- A1
- open access
Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells
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- Journal Article
- A1
- open access
Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection
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- Journal Article
- A2
- open access
Therapeutic anti-tumor immunity directed against neo-epitopes by intratumor delivery of mRNA encoding MLKL
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Vaccine options for influenza : thinking small
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Clinical potential of prefusion RSV F-specific antibodies
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Passively transferred M2e-specific monoclonal antibody reduces influenza A virus transmission in mice
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- Journal Article
- A2
- open access
Single-domain antibodies and their formatting to combat viral infections
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- Journal Article
- A1
- open access
Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein
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- Journal Article
- A1
- open access
Species specificity of type III interferon activity and development of a sensitive luciferase-based bioassay for quantitation of mouse interferon-λ
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- Journal Article
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- open access
Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
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Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist
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- Journal Article
- A1
- open access
A respiratory syncytial virus vaccine based on the small hydrophobic protein ectodomain presented with a novel lipid-based formulation is highly immunogenic and safe in adults : a first-in-humans study
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- Journal Article
- A1
- open access
Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy
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- Journal Article
- A1
- open access
Porous nanoparticles with self-adjuvanting M2e-fusion protein and recombinant hemagglutinin provide strong and broadly protective immunity against influenza virus infections
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Antibodies directed toward neuraminidase N1 control disease in a mouse model of influenza
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Transiently thermoresponsive acetal polymers for safe and effective administration of Amphotericin B as a vaccine adjuvant
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M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection
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- Journal Article
- A1
- open access
Removal of the N-glycosylation sequon at position N116 located in p27 of the respiratory syncytial virus fusion protein elicits enhanced antibody responses after DNA immunization
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- Miscellaneous
- open access
IgG3 snitcher of RSV infections in the very young
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Bronchoalveolar lavage of murine lungs to analyze inflammatory cell infiltration
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- Journal Article
- A1
- open access
Effect of serial pig passages on the adaptation of an avian H9N2 influenza virus to swine
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M2-based influenza vaccines : recent advances and clinical potential
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- Journal Article
- A1
- open access
A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine
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Chemical-controlled activation of antiviral myxovirus resistance protein 1
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Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection
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Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus
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- Journal Article
- A1
- open access
Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12
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- Journal Article
- A1
- open access
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
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Hierarchical and redundant roles of activating FcγRs in protection against influenza disease by M2e-specific IgG1 and IgG2a antibodies
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- Miscellaneous
- open access
One against all : a broadly influenza neutralizing man-made monoclonal antibody passes phase I
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Production and purification of recombinant filamentous bacteriophages displaying immunogenic heterologous epitopes
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- Journal Article
- A1
- open access
Influenza and memory T cells : how to awake the force
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- Journal Article
- A1
- open access
Illumina MiSeq sequencing disfavours a sequence motif in the GFP reporter gene
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Crystal structure of the conserved amino terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody
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Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling
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- Journal Article
- A1
- open access
Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies
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GM-CSF treatment prevents respiratory syncytial virus– induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation
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Increased protein degradation improves influenza virus nucleoprotein-specific CD8⁺ T cell activation in vitro but not in C57BL/6 mice
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Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination
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Phosphoproteomics to characterize host response during influenza A virus infection of human macrophages
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- Journal Article
- A1
- open access
A20 deficiency in lung epithelial cells protects against influenza A virus infection
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- Journal Article
- A1
- open access
Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine
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Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses
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Regulation of kynurenine biosynthesis during influenza virus infection
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Co-immunoprecipitation of the mouse Mx1 protein with the influenza A virus nucleoprotein
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Small hydrophobic protein of respiratory syncytial virus as a novel vaccine antigen
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- Journal Article
- A2
- open access
M2e-based universal influenza A vaccines
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- Journal Article
- A1
- open access
Analysis of the genetic diversity of influenza A viruses using next-generation DNA sequencing
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Influenza vaccines to control influenza-associated bacterial infection: where do we stand?
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Scop3D : three-dimensional visualization of sequence conservation
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Functional comparison of Mx1 from two different mouse species reveals the involvement of loop L4 in the antiviral activity against influenza A viruses
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- Journal Article
- A1
- open access
Protection against influenza A virus challenge with M2e-displaying filamentous Escherichia coli phages
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The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice
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Comparison of the antiviral activity of Mus spretus Mx1 and Mus musculus A2G Mx1 against influenza A viruses
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- Journal Article
- A1
- open access
A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody
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Sequence-dependent internalization of aggregating peptides
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Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody
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- Journal Article
- A1
- open access
Developing 3D SEM in a broad biological context
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Presenting heterologous epitopes with hepatitis B core-based virus-like particles
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CD8⁺ T cell immunity against human respiratory syncytial virus
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- Journal Article
- A1
- open access
Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin
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Metabolic profiling of insect cell lines: unveiling cell line determinants behind system's productivity
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Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge
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- Journal Article
- A1
- open access
Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein
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Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro
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Mx proteins: antiviral gatekeepers that restrain the uninvited
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Hepatitis B core-based virus-like particles to present heterologous epitopes
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Challenges and advances towards the rational design of mRNA vaccines
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Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice
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Natural and long-lasting cellular immune responses against influenza in the M2e-immune host
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- Journal Article
- A1
- open access
Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e
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- Journal Article
- A1
- open access
M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A
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The Sin3a repressor complex regulates the balance between the activities of different STAT proteins
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Insight into structural diversity of influenza virus haemagglutinin
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Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice
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Tailor-made cleavage site attenuates influenza B
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Influenza vaccines: T-cell responses deserve more attention
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- Book Chapter
- open access
Single domain camelid antibodies that neutralize negative strand viruses
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Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly
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Cutting edge approaches towards novel and cross-protective influenza vaccines
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- Journal Article
- A1
- open access
Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against Influenza A virus challenge
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- Journal Article
- A1
- open access
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection
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Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection
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The Sin3a repressor complex is a master regulator of STAT transcriptional activity
(2012) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109(30). p.12058-12063 -
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza A virus infection
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Protection against H5N1 influenza by immunoglobulin single variable domains
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Nanobodies®: new ammunition to battle viruses
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The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections
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- Journal Article
- A1
- open access
Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective
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Universal vaccine based on ectodomain of matrix protein 2 of Influenza A: Fc receptors and alveolar macrophages mediate protection
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- Journal Article
- A1
- open access
Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection
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A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus
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Nanobodies® specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion
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- Journal Article
- A1
- open access
Assessment of the antiviral properties of recombinant porcine SP-D against various influenza A viruses in vitro
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- Journal Article
- A1
- open access
Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules
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- Journal Article
- A1
- open access
Controlling influenza by cytotoxic T-cells : calling for help from destroyers
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Role of IFN-α during the acute stage of a swine influenza virus infection
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Identification of polymorphisms in the ovine Shadow of prion protein (SPRN) gene and assessment of their effect on promoter activity and susceptibility for classical scrapie
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The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
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PANDEMIC PREPAREDNESS: TOWARD A UNIVERSAL INFLUENZA VACCINE
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Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments
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M2e-based universal influenza A vaccine
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Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine
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- Journal Article
- A1
- open access
The influenza matrix protein 2 as a vaccine target
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Vaccine development by recombinant DNA technology. Part I: DNA Vaccines
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Vaccine development by recombinant DNA technology. Part II: Virus-like Particles
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Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies
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An influenza A vaccine based on tetrameric ectodomain of matrix protein 2
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CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine
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Proteome-wide identification of HtrA2/Omi substrates
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The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation
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- Journal Article
- A1
- open access
Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis
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Role of mitochondrial proteins in apoptosis.
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Necrosis is associated with IL-6 production but apoptosis is not
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Butylated hydroxyanisole is more than a reactive oxygen species scavenger
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The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection
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Improved design and intranasal delivery of an M2e-based human influenza A vaccine
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Apoptotic pathways and their regulation
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Mitochondria: Breathe or die
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Fas induced necrosis.
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Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1
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- Journal Article
- A1
- open access
Protein synthesis persists during necrotic cell death
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A novel caspase-2 complex containing TRAF2 and RIP1
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The use of proteomics in the study of cell death
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Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity
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Toxic proteins released from mitochondria in cell death
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INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1 beta generation
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Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD
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- Journal Article
- A1
- open access
Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production
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Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing
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Type II autophagic cell death and death-associated protein kinases
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Mitochondrial intermembrane proteins in cell death
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Caspase-mediated cleavage of the U snRNP-associated Sm-F protein during apoptosis
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Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death
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The caspase family
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A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand
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Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases
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Alice in caspase land. A phylogenetic analysis of caspases from worm to man.
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The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.
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Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA
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Caspases are not localized in mitochondria during life or death
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Translation inhibition in apoptosis - Caspase-dependent PKR activation and eIF2-alpha phosphorylation.
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Soluble recombinant influenza vaccines
(2001) PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES. 356(1416). p.1961-1963 -
Use of HDEL-tagged Trichoderma reesei mannosyl oligosaccharide 1,2-alpha-D-mannosidase for N-glycan engineering in Pichia pastoris.
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A universal influenza A vaccine based on the extracellular domain of the M2 protein.
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Protection of mice against a lethal influenza virus challenge after immunization with yeast-derived secreted influenza virus hemagglutinin.
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Modification of the protein glycosylation pathway in the methylotrophic yeast Pichia pastoris.
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Evaluation of recombinant A/Victoria/3/75 (H3N2) influenza neuraminidase mutants as potential broad-spectrum subunit vaccines against influenza A.
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In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mammalian-type oligosaccharides - Evidence for N-acetylglucosaminyltransferase-I-accepting glycans from Trichoderma reesei.
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Protection of mice against a lethal influenza challenge by immunization with yeast-derived recombinant influenza neuraminidase.
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Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells.
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A FAIRLY CONSERVED EPITOPE ON THE HEMAGGLUTININ OF INFLUENZA-A (H3N2) VIRUS WITH VARIABLE ACCESSIBILITY TO NEUTRALIZING ANTIBODY.
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Klonering, sekwentie-analyse en expressie van het RNA polymerasegen van het tabaksnecrose virus
(1991)