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Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound
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Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function
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- Journal Article
- A1
- open access
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data
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Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation
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99mTc-mebrofenin disposition in chimeric mice with a humanized liver
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Non-invasive method to obtain blood curves of 99mTc-mebrofenin
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In vivo visualization and quantification of (disturbed) Oatp-mediated hepatic uptake and Mrp2-mediated biliary excretion of 99mTc-mebrofenin in mice
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Molecular imaging as a non-invasive tool to visualize impaired hepatobiliary transporter function in Oatp1a/1b and Mrp2 knock-out mice
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In vivo µSPECT visualization of transport-mediated hepatic uptake and efflux of 99mTc-mebrofenin, and inhibition thereof with rifampicin
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Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use