Ghent University Academic Bibliography

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Rare sugar metabolism and impact on insulin sensitivity along the gut-liver-muscle axis in vitro

Amar Daniël Emanuel Van Laar (UGent) , Charlotte Grootaert (UGent) , Andreja Rajkovic (UGent) , Tom Desmet (UGent) , Koen Beerens (UGent) and John Van Camp (UGent)

(2023) NUTRIENTS. 15(7).
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Glycosidic linkage of rare and new-to-nature disaccharides reshapes gut microbiota in vitro

Stanley Omondi Onyango (UGent) , Koen Beerens (UGent) , Qiqiong Li (UGent) , John Van Camp (UGent) , Tom Desmet (UGent) and Tom Van de Wiele (UGent)

(2023) FOOD CHEMISTRY. 411.
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A colorimetric assay for the screening and kinetic analysis of nucleotide sugar 4,6-dehydratases

Ulrike Vogel (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2022) ANALYTICAL BIOCHEMISTRY. 655.
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Exploration of archaeal nucleotide sugar epimerases unveils a new and highly promiscuous GDP-Gal4E subgroup

Carlos Alvarez Quispe (UGent) , Matthieu Da Costa (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2022) CURRENT RESEARCH IN BIOTECHNOLOGY. 4. p.350-358
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Insertions and deletions in protein evolution and engineering

Simone Savino (UGent) , Tom Desmet (UGent) and Jorick Franceus (UGent)

(2022) BIOTECHNOLOGY ADVANCES. 60.
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Building mutational bridges between carbohydrate-active enzymes

Jorick Franceus (UGent) , Jolien Lormans (UGent) and Tom Desmet (UGent)

(2022) CURRENT OPINION IN BIOTECHNOLOGY. 78.
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In vitro stability and ex vivo absorption of thymol monoglucosides in the porcine gut

Noémie Van Noten, Elout Van Liefferinge (UGent) , Jeroen Degroote (UGent) , Stefaan De Smet (UGent) , Tom Desmet (UGent) and Joris Michiels (UGent)

(2022) ANIMAL. 16(1).
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Nucleotide sugar dehydratases : structure, mechanism, substrate specificity, and application potential

Ulrike Vogel (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2022) JOURNAL OF BIOLOGICAL CHEMISTRY. 298(4).
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Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

Silke Geurs (UGent) , Dorien Clarisse (UGent) , Freya Baele, Jorick Franceus (UGent) , Tom Desmet (UGent) , Karolien De Bosscher (UGent) and Matthias D'hooghe (UGent)

(2022) CHEMICAL COMMUNICATIONS. 58(42). p.6239-6242
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GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential

Koen Beerens (UGent) , Ophelia Gevaert and Tom Desmet (UGent)

(2022) FRONTIERS IN MOLECULAR BIOSCIENCES. 8.
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Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model

Amar Daniël Emanuel Van Laar (UGent) , Charlotte Grootaert (UGent) , Filip Van Nieuwerburgh (UGent) , Dieter Deforce (UGent) , Tom Desmet (UGent) , Koen Beerens (UGent) and John Van Camp (UGent)

(2022) NUTRIENTS. 14(3).
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Sweet biotechnology : enzymatic production and digestibility screening of novel kojibiose and nigerose analogues

Shari Dhaene (UGent) , Amar Daniël Emanuel Van Laar (UGent) , Marc De Doncker (UGent) , Emma De Beul (UGent) , Koen Beerens (UGent) , Charlotte Grootaert (UGent) , Jurgen Caroen (UGent) , Johan Van der Eycken (UGent) , John Van Camp (UGent) and Tom Desmet (UGent)

(2022) JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 70(11). p.3502-3511
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Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Jorick Franceus (UGent) , Jolien Lormans (UGent) , Lore Cools, Matthias D'hooghe (UGent) and Tom Desmet (UGent)

(2021) ACS CATALYSIS. 11(10). p.6225-6233
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Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol

Jorick Franceus (UGent) , Zorica Ubiparip (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) CHEMBIOCHEM. 22(18). p.2777-2782
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Defined synthesis of cellotriose by cellobiose phosphorylase mutant

Zorica Ubiparip (UGent) , David Sáez, Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) International Symposium on Biocatalysis and Biotransformations (Biotrans 2021), Abstracts.
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Engineering of cellobiose phosphorylase for the synthesis of prebiotic cellotriose

Zorica Ubiparip (UGent) , David Sáez Moreno, Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) International Conference on Renewable Resources & Biorefineries, 17th, Abstracts.
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Enzymatic synthesis of phloretin α‐glucosides using a sucrose phosphorylase mutant and its effect on solubility, antioxidant properties and skin absorption

Jose Luis González Alfonso, Zorica Ubiparip (UGent) , Elena Jimenez‐Ortega, Ana Poveda, Cristina Alonso, Luisa Coderch, Jesus Jimenez‐Barbero, Julia Sanz‐Aparicio, Antonio O. Ballesteros, Tom Desmet (UGent) , et al.

(2021) ADVANCED SYNTHESIS & CATALYSIS. 363(12). p.3079-3089
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β-Glucan phosphorylases in carbohydrate synthesis

Zorica Ubiparip (UGent) , Marc De Doncker (UGent) , Koen Beerens (UGent) , Jorick Franceus (UGent) and Tom Desmet (UGent)

(2021) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 105(10). p.4073-4087
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Exploration of GH94 sequence space for enzyme discovery reveals a novel glucosylgalactose phosphorylase specificity

Marc De Doncker (UGent) , Chloé De Graeve, Jorick Franceus (UGent) , Koen Beerens (UGent) , Vladimír Křen, Helena Pelantová, Ronny Vercauteren and Tom Desmet (UGent)

(2021) CHEMBIOCHEM. 22(23). p.3319-3325
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Towards sustainable production of defined oligosaccharides : enzymatic synthesis of high purity cellotriose

Zorica Ubiparip (UGent) , David Sáez Moreno, Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) EFIB 2021, Abstacts.
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Discovery of a novel GDP-glucose 4-epimerase in archaea reveals an uncommon promiscuity

Carlos Alvarez Quispe (UGent) , Matthieu Da Costa (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) ProtStab2021, 13th International Conference on Protein Stabilization, Abstracts.
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Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering

Matthieu Da Costa (UGent) , Ophelia Gevaert, Stevie Van Overtveldt, Joanna Lange, Henk-Jan Joosten, Tom Desmet (UGent) and Koen Beerens (UGent)

(2021) BIOTECHNOLOGY ADVANCES. 48.
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Stereo-electronic control of reaction selectivity in short-chain dehydrogenases : decarboxylation, epimerization, and dehydration

Annika J.E. Borg, Koen Beerens (UGent) , Martin Pfeiffer, Tom Desmet (UGent) and Bernd Nidetzky

(2021) CURRENT OPINION IN CHEMICAL BIOLOGY. 61. p.43-52
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Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion

Christian Rapp, Stevie Van Overtveldt, Koen Beerens (UGent) , Hansjörg Weber, Tom Desmet (UGent) and Bernd Nidetzky

(2021) APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 87(4).
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Kojibiose and trehalose long-term supplementation reveals significant metabolic differences and disaccharide dependent microbial community shift in a human gastrointestinal model

Stanley Omondi Onyango (UGent) , Koen Beerens (UGent) , Xinlin Jiao, Tom Desmet (UGent) and Tom Van de Wiele (UGent)

(2021) 9th Microbiome & Probiotics R&D and Business Collaboration Forum, Abstracts.
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Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65

Emma De Beul (UGent) , Alana Jongbloet, Jorick Franceus (UGent) and Tom Desmet (UGent)

(2021) MOLECULES. 26(20).
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Effects of thymol and thymol α-D-Glucopyranoside on intestinal function and microbiota of weaned pigs

Noémie Van Noten, Jeroen Degroote (UGent) , Elout Van Liefferinge (UGent) , Bernard Taminiau, Stefaan De Smet (UGent) , Tom Desmet (UGent) and Joris Michiels (UGent)

(2020) ANIMALS. 10(2).
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Synthesis, trehalase hydrolytic resistance and inhibition properties of 4-and 6-substituted trehalose derivatives

Shari Dhaene (UGent) , Johan Van der Eycken (UGent) , Koen Beerens (UGent) , Jorick Franceus (UGent) , Tom Desmet (UGent) and Jurgen Caroen (UGent)

(2020) JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 35(1). p.1964-1989
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Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases

Benoît Desguin, Julian Urdiain-Arraiza, Matthieu Da Costa (UGent) , Matthias Fellner, Jian Hu, Robert P. Hausinger, Tom Desmet (UGent) , Pascal Hols and Patrice Soumillion

(2020) SCIENTIFIC REPORTS. 10(1).
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Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity

Tim Van de Walle, Marina Briand, Ana Mitrović, Izidor Sosič, Stanislav Gobec, Janko Kos, Leentje Persoons, Dirk Daelemans, Steven De Jonghe, Zorica Ubiparip (UGent) , et al.

(2020) CHEMMEDCHEM. 15(24). p.2477-2490
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Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose

Zorica Ubiparip (UGent) , David Sáez Moreno, Koen Beerens (UGent) and Tom Desmet (UGent)

(2020) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 104(19). p.8327-8337
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Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13 : discovery, application and engineering

Jorick Franceus (UGent) and Tom Desmet (UGent)

(2020) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21(7).
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Weaning affects the glycosidase activity towards phenolic glycosides in the gut of piglets

Noémie Van Noten, Elout Van Liefferinge (UGent) , Jeroen Degroote (UGent) , Stefaan De Smet (UGent) , Tom Desmet (UGent) and Joris Michiels (UGent)

(2020) JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION. 104(5). p.1432-1443
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Fate of thymol and its monoglucosides in the gastrointestinal tract of piglets

Noémie Van Noten, Elout Van Liefferinge (UGent) , Jeroen Degroote (UGent) , Stefaan De Smet (UGent) , Tom Desmet (UGent) and Joris Michiels (UGent)

(2020) ACS OMEGA. 5(10). p.5241-5248
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Determinants of the nucleotide specificity in the carbohydrate epimerase family 1

Stevie Van Overtveldt, Matthieu Da Costa (UGent) , Ophelia Gevaert, Henk-Jan Joosten, Koen Beerens (UGent) and Tom Desmet (UGent)

(2020) BIOTECHNOLOGY JOURNAL. 15(11).
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GDP-altrose as novel product of GDP-mannose 3,5-epimerase : revisiting its reaction mechanism

Ophelia Gevaert, Stevie Van Overtveldt, Matthieu Da Costa (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2020) INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 165(part B). p.1862-1868
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Novel insights into the existence of the putative UDP-glucuronate 5-epimerase specificity

Ophelia Gevaert, Stevie Van Overtveldt, Matthieu Da Costa (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2020) CATALYSTS. 10(2).
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Fermentation of rare sugar kojibiose by the oral bacteria is slow yet bacteria specific

Stanley Omondi Onyango (UGent) , Nele De Clercq, Koen Beerens (UGent) , Tom Desmet (UGent) and Tom Van de Wiele (UGent)

(2020) NSABS 2020, 25th National Symposium for Applied Biological Sciences, Abstracts.
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Oral microbiota display profound differential metabolic kinetics and community shifts upon incubation with sucrose, trehalose, kojibiose, and xylitol

Stanley Omondi Onyango (UGent) , Nele De Clercq, Koen Beerens (UGent) , John Van Camp (UGent) , Tom Desmet (UGent) and Tom Van de Wiele (UGent)

(2020) APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 86(16).
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Effect of age on the functional glycosidase activity in the small intestinal mucosa of piglets

Noémie Van Noten, Elout Van Liefferinge (UGent) , Jeroen Degroote (UGent) , Tom Desmet (UGent) , Stefaan De Smet (UGent) and Joris Michiels (UGent)

(2019) Book of abstracts of the 70th Annual Meeting of the European Federation of Animal Science.
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Structural features on the substrate-binding surface of fungal lytic polysaccharide monooxygenases determine their oxidative regioselectivity

Barbara Danneels, Magali Tanghe (UGent) and Tom Desmet (UGent)

(2019) BIOTECHNOLOGY JOURNAL. 14(3).
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Rational design of an improved transglucosylase for production of the rare sugar nigerose

Jorick Franceus (UGent) , Shari Dhaene (UGent) , Hannes Decadt (UGent) , Judith Vandepitte, Jurgen Caroen (UGent) , Johan Van der Eycken (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2019) CHEMICAL COMMUNICATIONS. 55(31). p.4531-4533
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CARBAFIN : developing a glycosylation platform technology to an industrial level

Zorica Ubiparip (UGent) , Christiane Luley, Tom Desmet (UGent) and Bernd Nidetzky

(2019) Renewable Resources and Biorefineries 15, Abstracts.
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Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves Depetter, Silke Geurs (UGent) , Jorick Franceus (UGent) , Damijan Knez, Tom Desmet (UGent) , Karolien De Bosscher (UGent) , Olivier De Wever (UGent) , Stanislav Gobec and Matthias D'hooghe (UGent)

(2019) CHEMISTRYSELECT. 4(42). p.12308-12312
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Discovery of novel cellodextrin phosphorylases : where bioinformatics meets biochemistry

Zorica Ubiparip (UGent) , Jorick Franceus (UGent) , Nídia Martins, Koen Beerens (UGent) and Tom Desmet (UGent)

(2019) European Summit of Industrial Biotechnology 2019, Abstracts.
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Structural comparison of a promiscuous and a highly specific sucrose 6F-phosphate phosphorylase

Jorick Franceus (UGent) , Nikolas Capra, Tom Desmet (UGent) and Andy-Mark W.H. Thunnissen

(2019) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(16).
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Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates

Atiruj Theppawong (UGent) , Tim Van de Walle, Charlotte Grootaert (UGent) , Kristof Van Hecke (UGent) , Nathalie Catry, Tom Desmet (UGent) , John Van Camp (UGent) and Matthias D'hooghe (UGent)

(2019) CHEMISTRYOPEN. 8(2). p.236-247
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Characterization of the first bacterial and thermostable GDP-mannose 3,5-epimerase

Ophelia Gevaert, Stevie Van Overtveldt, Koen Beerens (UGent) and Tom Desmet (UGent)

(2019) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(14).
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Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines

Atiruj Theppawong (UGent) , Tim Van de Walle, Charlotte Grootaert (UGent) , Margot Bultinck, Tom Desmet (UGent) , John Van Camp (UGent) and Matthias D'hooghe (UGent)

(2018) CHEMISTRYOPEN. 7(5). p.381-392
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Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase

Jorick Franceus (UGent) , Lena Decuyper, Matthias D'hooghe (UGent) and Tom Desmet (UGent)

(2018) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 102(7). p.3183-3191

Rare sugar metabolism and impact on insulin sensitivity along the gut-liver-muscle axis in vitro

Glycosidic linkage of rare and new-to-nature disaccharides reshapes gut microbiota in vitro

A colorimetric assay for the screening and kinetic analysis of nucleotide sugar 4,6-dehydratases

Exploration of archaeal nucleotide sugar epimerases unveils a new and highly promiscuous GDP-Gal4E subgroup

Insertions and deletions in protein evolution and engineering

Building mutational bridges between carbohydrate-active enzymes

In vitro stability and ex vivo absorption of thymol monoglucosides in the porcine gut

Nucleotide sugar dehydratases : structure, mechanism, substrate specificity, and application potential

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential

Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model

Sweet biotechnology : enzymatic production and digestibility screening of novel kojibiose and nigerose analogues

Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol

Defined synthesis of cellotriose by cellobiose phosphorylase mutant

Engineering of cellobiose phosphorylase for the synthesis of prebiotic cellotriose

Enzymatic synthesis of phloretin α‐glucosides using a sucrose phosphorylase mutant and its effect on solubility, antioxidant properties and skin absorption

β-Glucan phosphorylases in carbohydrate synthesis

Exploration of GH94 sequence space for enzyme discovery reveals a novel glucosylgalactose phosphorylase specificity

Towards sustainable production of defined oligosaccharides : enzymatic synthesis of high purity cellotriose

Discovery of a novel GDP-glucose 4-epimerase in archaea reveals an uncommon promiscuity

Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering

Stereo-electronic control of reaction selectivity in short-chain dehydrogenases : decarboxylation, epimerization, and dehydration

Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion

Kojibiose and trehalose long-term supplementation reveals significant metabolic differences and disaccharide dependent microbial community shift in a human gastrointestinal model

Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65

Effects of thymol and thymol α-D-Glucopyranoside on intestinal function and microbiota of weaned pigs

Synthesis, trehalase hydrolytic resistance and inhibition properties of 4-and 6-substituted trehalose derivatives

Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases

Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity

Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose

Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13 : discovery, application and engineering

Weaning affects the glycosidase activity towards phenolic glycosides in the gut of piglets

Fate of thymol and its monoglucosides in the gastrointestinal tract of piglets

Determinants of the nucleotide specificity in the carbohydrate epimerase family 1

GDP-altrose as novel product of GDP-mannose 3,5-epimerase : revisiting its reaction mechanism

Novel insights into the existence of the putative UDP-glucuronate 5-epimerase specificity

Fermentation of rare sugar kojibiose by the oral bacteria is slow yet bacteria specific

Oral microbiota display profound differential metabolic kinetics and community shifts upon incubation with sucrose, trehalose, kojibiose, and xylitol

Effect of age on the functional glycosidase activity in the small intestinal mucosa of piglets

Structural features on the substrate-binding surface of fungal lytic polysaccharide monooxygenases determine their oxidative regioselectivity

Rational design of an improved transglucosylase for production of the rare sugar nigerose

CARBAFIN : developing a glycosylation platform technology to an industrial level

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Discovery of novel cellodextrin phosphorylases : where bioinformatics meets biochemistry

Structural comparison of a promiscuous and a highly specific sucrose 6F-phosphate phosphorylase

Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates

Characterization of the first bacterial and thermostable GDP-mannose 3,5-epimerase

Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines

Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase