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- Journal Article
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Increased dentate gyrus excitability in the intrahippocampal kainic acid mouse model for temporal lobe epilepsy
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- Journal Article
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- open access
In vivo inhibition of epileptiform afterdischarges in rat hippocampus by light-activated chloride channel, stGtACR2
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Investigating the mechanism of action of tDCS by means of TMS-EMG
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- Conference Paper
- C3
- open access
Chemogenetic activation of the locus coeruleus increases noradrenaline levels in the hippocampus and modulates its hippocampal excitability
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- Journal Article
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Deep brain stimulation of the anterior nucleus of the thalamus in drug resistant epilepsy in the MORE multicenter patient registry
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- Journal Article
- A1
- open access
Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus
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Translational veterinary epilepsy : a win-win situation for human and veterinary neurology
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Chemogenetic seizure control with clozapine and the novel ligand JHU37160 outperforms the effects of Levetiracetam in the intrahippocampal kainic acid mouse model
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Transcutaneous auricular vagus nerve stimulation cannot modulate the P3b event-related potential in healthy volunteers
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Cathodal transcranial direct current stimulation : impact of the ring radius of a 4x1-ring electrode configuration
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- Journal Article
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Auricular transcutaneous vagus nerve stimulation modulates the heart-evoked potential
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- Conference Paper
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Hippocampal seizures strongly modulate the activity of locus coeruleus neurons
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- Journal Article
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White matter integrity in a rat model of epileptogenesis : structural connectomics and fixel-based analysis
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- Journal Article
- A1
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Ex vivo feedback control of neurotransmission using a photocaged adenosine A1 receptor agonist
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Investigating the effect of transcutaneous auricular vagus nerve stimulation on cortical excitability in healthy males
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Event-related potentials following cutaneous electrical stimulation in patients with chronic whiplash-associated disorders
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- Journal Article
- A1
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The potential of invasive and non-invasive vagus nerve stimulation to improve verbal memory performance in epilepsy patients
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Laryngeal muscle-evoked potential recording as an indicator of vagal nerve fiber activation
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- Journal Article
- A1
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Continuous theta burst stimulation for drug-resistant epilepsy
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Recent advances in the use of focused ultrasound as a treatment for epilepsy
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- Conference Paper
- C3
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Feedback control of CA1 excitability in hippocampal slices with a photoactive adenosine A1 receptor agonist
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- Conference Paper
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Optical control of excitatory transmission in hippocampal slices with photoactive adenosine A1 receptor agonist
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Long‐term chemogenetic suppression of seizures in a multifocal rat model of temporal lobe epilepsy
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- Journal Article
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Technological challenges in the development of optogenetic closed-loop therapy approaches in epilepsy and related network disorders of the brain
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Severe autonomic nervous system imbalance in Lennox-Gastaut syndrome patients demonstrated by heart rate variability recordings
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- Conference Paper
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Optical control of excitatory transmission in hippocampal slices with photoactive adenosine A1 receptor agonist
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- Journal Article
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Optimized parameters for transducing the locus coeruleus using canine adenovirus type 2 (CAV2) vector in rats for chemogenetic modulation research
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- Journal Article
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Comparison of in vivo and ex vivo magnetic resonance imaging in a rat model for glioblastoma-associated epilepsy
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- Journal Article
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Level of hM4D(Gi) DREADD expression determines inhibitory and neurotoxic effects in the hippocampus
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- Journal Article
- A1
- open access
Attenuation of hippocampal evoked potentials in vivo by activation of GtACR2, an optogenetic chloride channel
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Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation
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- Journal Article
- A1
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International consensus based review and recommendations for minimum reporting standards in research on transcutaneous vagus nerve stimulation (version 2020)
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SARS-CoV-2 vaccine-related neurological complications need large collaborative studies, not single case reports or small descriptive series
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Non-invasive vagal nerve stimulation enhances cognitive emotion regulation
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Electroencephalography during nociceptive stimulation in chronic pain patients : a systematic review
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- Journal Article
- A1
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Development of a rat model for glioma-related epilepsy
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- Journal Article
- A1
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Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2
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- Journal Article
- A1
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Repetitive transcranial magnetic stimulation in drug‐resistant idiopathic epilepsy of dogs : a noninvasive neurostimulation technique
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- Conference Paper
- C3
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The effect of chemogenetic hippocampal suppression on evoked potentials and seizures in a multifocal rat model for temporal lobe epilepsy
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Acute symptomatic seizures following intracerebral hemorrhage in the rat collagenase model
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- Journal Article
- A1
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Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects
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- Journal Article
- A1
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A feasibility study to investigate chemogenetic modulation of the locus coeruleus by means of single unit activity
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Deep brain stimulation reduces evoked potentials with a dual time course in freely moving rats : potential neurophysiological basis for intermittent as an alternative to continuous stimulation
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- Journal Article
- A1
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Neurophysiological investigations of drug resistant epilepsy patients treated with vagus nerve stimulation to differentiate responders from non-responders
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- Journal Article
- A1
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Transcutaneous vagus nerve stimulation does not affect verbal memory performance in healthy volunteers
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Transcranial magnetic stimulation as a tool for the evaluation of neuromodulatory effects of transcutaneous vagus nerve stimulation
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Acute symptomatic seizures in the collagenase model for intracerebral hemorrhage
(2020) INTERNATIONAL JOURNAL OF STROKE. In International Journal of Stroke 15(Supplement 1). p.618-618 -
- Conference Paper
- C3
- open access
Long-term effect of chemogenetic suppression of excitatory hippocampal neurons on spontaneous seizures in a rat model for temporal lobe epilepsy
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- Miscellaneous
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Is vagus nerve stimulation effective in the treatment of drug-resistant epilepsy?
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- Conference Paper
- C3
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Effect of chemogenetic modulation of hippocampal neurons on depression and spatial memory impairment in a rat model for temporal lobe epilepsy
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- Conference Paper
- C3
- open access
Chemogenetic suppression of spontaneous seizures in a rat model for temporal lobe epilepsy
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- Conference Paper
- C3
- open access
Effect of chemogenetic modulation of hippocampal neurons on depression and spatial memory impairment in a rat model for temporal lobe epilepsy
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- Conference Paper
- C3
- open access
Chemogenetic suppression of excitatory hippocampal neurons in non-epileptic and epileptic rats
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VNS responders have a significant higher amount of deep sleep : the Adenosine hypothesis
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Laryngeal muscle-evoked potentials as an indicator of vagus nerve activation
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- Journal Article
- A1
- open access
Vagus nerve stimulation-induced laryngeal motor evoked potentials : a possible biomarker of effective nerve activation
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Genetic modification of Locus Coeruleus NE cells for chemogenetic activation remains challenging
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Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.
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- Journal Article
- A1
- open access
Alterations in the functional brain network in a rat model of epileptogenesis : a longitudinal resting state fMRI study
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- Journal Article
- A1
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Hypothermia masks most of the effects of rapid cycling VNS on rat hippocampal electrophysiology
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- Conference Paper
- C3
- open access
Chemogenetic therapy strongly suppresses hippocampal excitability and spontaneous seizures in a rat model for temporal lobe epilepsy
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- Conference Paper
- C3
- open access
The effect of chemogenetic inhibition of excitatory neurons on hippocampal excitability and seizure frequency in a rat model
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Recent advances in devices for vagus nerve stimulation
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Reduced distractor interference during vagus nerve stimulation
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Laryngeal muscle-evoked potentials to evaluate vagus nerve activation
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TMS-EEG as a tool to study the neuromodulatory effects of theta burst stimulation
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- Conference Paper
- C3
- open access
Vagus nerve stimulation induced hypothermia drives most of the effects on hippocampal electrophysiology in rats
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- Conference Paper
- C3
- open access
Vagus nerve stimulation induced hypothermia drives most of the effects on hippocampal electrophysiology in rats
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- Conference Paper
- C3
- open access
Chemogenetic silencing of excitatory hippocampal neurons prevents spontaneous seizures in a mouse model for temporal lobe epilepsy
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- Conference Paper
- C3
- open access
Chemogenetic silencing of excitatory hippocampal neurons prevents spontaneous seizures in a mouse model for temporal lobe epilepsy
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- Conference Paper
- C3
- open access
Chemogenetic silencing of excitatory hippocampal neurons prevents spontaneous seizures in a mouse model for temporal lobe epilepsy
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- Conference Paper
- C3
- open access
Chemogenetic silencing of excitatory hippocampal neurons prevents spontaneous seizures in a mouse model for temporal lobe epilepsy
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Chemogenetic silencing of excitatory hippocampal neurons prevents spontaneous seizures in a mouse model for temporal lobe epilepsy
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Laryngeal motor-evoked potentials as an indicator of vagus nerve activation
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Efficacy and safety of the AspireSR (R) VNS at Ghent University Hospital, Belgium
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- Conference Paper
- C3
- open access
Induction of DREADD expression in the rat locus coeruleus and its effects on neuronal firing
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- Conference Paper
- C3
- open access
Induction of DREADD expression in the rat locus coeruleus and its effects on neuronal firing
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- Conference Paper
- C3
- open access
Induction of DREADD expression in the rat locus coeruleus and its effects on neuronal firing
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- Conference Paper
- C3
- open access
The effect of chemogenetic inhibition of excitatory neurons on hippocampal excitability and seizure frequency in a rat model
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- Conference Paper
- C3
- open access
The effect of chemogenetic inhibition of excitatory neurons on hippocampal excitability and seizure frequency in a rat model
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Pseudopheochromocytoma as a potential side effect of VNS in refractory epilepsy : a case report
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EEG source connectivity to localize the seizure onset zone from clinical ictal EEG in refractory epilepsy patients
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Deep brain stimulation in epilepsy
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A prestimulation evaluation protocol for patients with drug resistant epilepsy
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- Journal Article
- A2
- open access
Automated long-term EEG analysis to localize the epileptogenic zone
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- Journal Article
- A1
- open access
EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy
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Cognitive deterioration in adult epilepsy : clinical characteristics of 'Accelerated Cognitive Ageing'
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- Journal Article
- A1
- open access
Deep brain and cortical stimulation for epilepsy
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- Conference Paper
- C3
- open access
Continuous thetaburst stimulation for the treatment of refractory neocortical epilepsy
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- Journal Article
- A1
- open access
Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy
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Clinical vagus nerve stimulation paradigms induce pronounced brain and body hypothermia in rats
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- Conference Paper
- C3
- open access
EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy
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EEG derived brain activity reflects treatment response from vagus nerve stimulation in patients with epilepsy
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Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures
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Vagus nerve stimulation applied with a rapid cycle has more profound influence on hippocampal electrophysiology than a standard cycle
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Technical aspects of neurostimulation : focus on equipment, electric field modeling, and stimulation protocols
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- Journal Article
- A1
- open access
Electrical source imaging of interictal spikes using multiple sparse volumetric priors for presurgical epileptogenic focus localization
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The role of skull modeling in EEG source imaging for patients with refractory temporal lobe epilepsy
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The effect of neuropeptide FF in the amygdala kindling model
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Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy
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Autonomic nervous system functioning associated with psychogenic nonepileptic seizures : analysis of heart rate variability
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Impact of nervus vagus stimulation on objective vocal quality, a pilot study
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- Journal Article
- A1
- open access
Functional MRI during hippocampal deep brain stimulation in the healthy rat brain
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- Journal Article
- A1
- open access
A prospective, multicenter study of cardiac-based seizure detection to activate vagus nerve stimulation
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- Conference Paper
- P1
- open access
End user needs elicitation for a full-body exoskeleton to assist the elderly
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The antidepressant-like effect of vagus nerve stimulation is mediated through the locus coeruleus
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A preclinical study of laryngeal motor-evoked potentials as a marker vagus nerve activation
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Responsive neurostimulation in epilepsy
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Diagnostic methods and treatment options for focal cortical dysplasia
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The antidepressant mechanism of action of vagus nerve stimulation: evidence from preclinical studies
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Aanvallen na een ongeval
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The systemic kainic acid rat model of temporal lobe epilepsy: long-term EEG monitoring
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Impact of vagal nerve stimulation on objective vocal quality, a pilot study
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In search of optimal DBS paradigms to treat epilepsy: bilateral versus unilateral hippocampal stimulation in a rat model for temporal lobe epilepsy
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Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors
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- Journal Article
- A1
- open access
Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect
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Vagus nerve stimulation has antidepressant effects in the kainic acid model for temporal lobe epilepsy
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Closing the loop for patients with epilepsy
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Lokalisatie van de epileptische focus op basis van netwerkanalyse van hersensignalen
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- Journal Article
- A1
- open access
Tracking slow modulations in synaptic gain using dynamic causal modelling : validation in epilepsy
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Neurophysiological correlates of dissociative symptoms
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Non-pharmalogical treatment options for refractory epilepsy: an overview of human treatment modalities and their potential utility in dogs
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Vagus nerve stimulation... 25 years later!: what do we know about the effects on cognition?
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Resting-state networks and dissociation in psychogenic non-epilepstic seizures
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- Journal Article
- A1
- open access
Deep brain and cortical stimulation for epilepsy
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- Journal Article
- A2
- open access
Magentoencefalografie en epilepsie
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- Conference Paper
- C3
- open access
Source reconstruction of the P300 event-related potential as a biomarker for the efficacy of vagus nerve stimulation in patients with epilepsy
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- Conference Paper
- C3
- open access
FMRI of hippocampal deep brain stimulation in the rodent brain
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Vagus nerve stimulation decreases hippocampal and prefrontal EEG power in freely moving rats: a biomarker for effective stimulation?
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- Conference Paper
- C3
- open access
Statistical group-analysis of PET data reveals whole-brain effect of hippocampal deep brain stimulation
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The P3 event-related potential is a biomarker for the efficacy of vagus nerve stimulation in patients with epilepsy
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Vagus nerve stimulation triggered by ictal tachycardia-based seizure detection, a prospective multi-site study
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Unilateral vs. bilateral hippocampal DBS in a rat model for temporal lobe epilepsy
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Vagus nerve stimulation has antidepressant effects in the kainic acid model for temporal lobe epilepsy
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Allopurinol reduces seizure severity and the inflammatory response in a mouse model for status epilepticus : a potential role for uric acid in ictogenesis
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A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy
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Ictal-onset localization through connectivity analysis of intracranial EEG signals in patients with refractory epilepsy
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Subgroup classification in patients with psychogenic non-epileptic seizures
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Effective connectivity analysis of intracranial EEG recordings during epileptic seizures
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Invasive brain stimulation in the treatment of epilepsy
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Increased cognitive control during norepinephrine release through acute vagus nerve stimulation
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Clinical added value of magnetic source imaging in the presurgical evaluation of refractory focal epilepsy
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Hippocampal deep brain stimulation may be an alternative for resective surgery in medically refractory temporal lobe epilepsy
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A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy
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Deep brain stimulation early during epileptogenesis modifies disease progression in temporal lobe epilepsy
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Hippocampal deep brain stimulation has antiepileptogenic potential
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- Conference Paper
- C3
- open access
A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy
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Neurostimulation for epilepsy
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- Journal Article
- A1
- open access
Mapping the epileptic brain with EEG dynamical connectivity: established methods and novel approaches
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The effect of high frequency, Poisson distributed cortical stimulation on cortical excitability in rats
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Vagus nerve stimulation has antidepressant potential in the kainic acid model for temporal lobe epilepsy
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- Conference Paper
- C3
- open access
Brain mapping of an epileptic brain using EEG functional and effective connectivity
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Functional connectivity of dissociation in patients with psychogenic non-epileptic seizures
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Attentional emotion control in dysphoric and non-dysphoric patients with epilepsy
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Is cortical excitability in rats altered after 1h of high frequency, Poisson distributed cortical stimulation?
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Vagal nerve stimulation and deep brain stimulation in epilepsy
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Deep brain stimulation early during epileptogenesis modifies disease progression in the hippocampus
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A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy
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Electrophysiological responses to vagus nerve stimulation in rats
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Poisson distributed deep brain stimulation (DBS) in the ventral hippocampal commissure suppresses seizures in the kainic acid rat model
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The management of pharmacologically refractory epilepsy
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The cognitive effects of amygdalohippocampal deep brain stimulation in patients with temporal lobe epilepsy
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Epileptogenic focus localization through connectivity analysis of the intracranial eeg
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Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome
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- Conference Paper
- C3
- open access
Pilot-trial : high frequency, Poisson distributed cortical stimulation in a screening model for epileptic seizures
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Long term hippocampal deep brain stimulation efficiently reduces seizures in the kainic acid model
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Local delivery strategies in epilepsy: a focus on adenosine
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Efficacy of vagus nerve stimulation for refractory epilepsy among patient subgroups: a re-analysis using the Engel classification
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Magnetoencephalography in epilepsy patients carrying a vagus nerve stimulator
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Recording temporal lobe epileptic activity with MEG in a light-weight magnetic shield
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Early seizures in intracerebral haemorrhage: incidence, associated factors and outcome
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Hippocampal deep brain stimulation early during epileptogenesis affects spontaneous seizures in the kainic acid rat model
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Auditory and visual naming in patients with lateralized refractory epilepsy: initial experience at Ghent University Hospital
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Electrophysiological responses to vagus nerve stimulation in rats
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Epileptogenic focus localization through connectivity analysis of the intracranial EEG: a retrospective study in 2 patients
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Memory performance after amygdalohippocampal deep brain stimulation in patients with medically refractory temporal lobe epilepsy
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Surgical successes and failures of invasive video-EEG monitoring in the presurgical evaluation of epilepsy
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Accurate epileptogenic focus localization through time-variant functional connectivity analysis of intracranial electroencephalographic signals
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Deep brain and cerebellar stimulation for epilepsy
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Effect of levetiracetam on hippocampal protein expression and cell proliferation in rats
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Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery
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Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures
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Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures
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Predictive factors for outcome of invasive video-EEG monitoring and subsequent resective surgery in patients with refractory epilepsy
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Evolution in VNS therapy for refractory epilepsy, experience with Demipulse devices at Ghent University Hospital
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A novel implantable vagus nerve stimulation system (ADNS-300) for combined stimulation and recording of the vagus nerve: pilot trial at Ghent University Hospital
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Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation
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A novel implantable vagus nerve stimulation system (ADNS-300): pilot trial at Ghent University Hospital
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Hippocampal deep brain stimulation reveals decreased rCBF in the hippocampus of the rat: a mu spect study
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The value of MEG in the presurgical evaluation of patients with refractory epilepsy
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Adenosine secretion by neural stem cells isolated from ADK-/- mice
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Local infusion of neuropeptide Y has anti-epileptic effects in fully kindled rats
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Anti-epileptic effects of vagus nerve stimulation in the focal pilocarpine model
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Clinical added value of MEG in patients with refractory partial epilepsy and non-localizing conventional presurgical evaluation
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Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat
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Electrical Stimulation for the Treatment of Epilepsy
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Deep Brain Stimulation for epilepsy: knowledge gained from experimental animal models
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Vagal nerve stimulation: a 15-year survey of an established treatment modality in epilepsy surgery
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Vagus nerve stimulation for refractory status epilepticus
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Effect of hippocampal deep brain stimulation on blood perfusion evaluated by SPECT
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Identification of a brainstem evoked potential following cervical vagus nerve stimulation in rats
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Increased hippocampal extracellular noradrenalin concentration contributes to the anticonvulsant effect of VNS in the focal pilocarpine rat model for limbic seizures
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Local delivery and cell therapy for the treatment of refractory epilepsy
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Secretion of adenosine by foetal neural stem cells isolated from adenosine kinase deficient mice
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Recording temporal epileptic activity with MEG using a light weight magnetic shield
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Effect of levetiracetam on hippocampal protein expression and cell proliferation in rats
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Anti-epileptic effects of vagus nerve stimulation in the focal pilocarpine model
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HIPPOCAMPAL HIGH FREQUENCY DEEP BRAIN STIMULATION REDUCES SEIZURE FREQUENCY IN THE KAINIC ACID MODEL
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In vivo measurements of vagus nerve compound action potentials in experimental rats
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Local infusion of neuropeptide Y has anti-epileptic effects in kindled rats
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Hippocampal deep brain stimulation
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EFFECT OF ACUTE AND LONG-TERM VAGUS NERVE STIMULATION IN FULLY KINDLED RATS
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Beneficial effect of add-on levetiracetam in patients treated with vagus nerve stimulation for refractory epilepsy
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The identification of prognostic factors prior to invasive video-EEG monitoring
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Prospective multicenter screening of migraine criteria in Belgian patients with epilepsy
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Recording epileptiform activity with magnetoencephalography in patients with refractory epilepsy implanted with a vagus nerve stimulator is feasible and presents added value in the presurgical evaluation
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High frequency stimulation in the hippocampus reduces the frequency of seizures in kainic acid injected rats
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- Conference Paper
- C3
- open access
Raw EEG Characteristics during a case of propofol induced myoclonial movements
(2008) -
Transplantation of neural progenitor cells in a sclerotic hippocampus give long term survival and differentiate mainly towards astrocytes
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Intrahippocampal delivery of adenosine reduces frequency of spontaneous seizures in the kainic acid rat model
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Vagus nerve compound action potentials (CAPs) verify vagus nerve stimulation in rats
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Invasive video-EEG monitoring, the experience at Ghent University Hospital
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Epilepsy surgery: diagnosis, techniques, outcome
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Efficacy of vagus nerve stimulation for refractory epilepsy among patient subgroups
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Detection of focal epileptiform events in the EEG by spatio-temporal dipole clustering
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A pilot trial with modified Atkins' diet in adult patients with refractory epilepsy
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Thalamic and limbic involvement in the mechanism of action of vagus nerve stimulation, a SPECT study
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CONTRIBUTION OF MAGNETIC SOURCE IMAGING TO THE PRESURGICAL WORK-UP OF PATIENTS WITH REFRACTORY PARTIAL EPILEPSY
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Cognitive effects of deep brain stimulation in patients with refractory epilepsy
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Neuropsychological outcome of bilateral hippocampal stimulation for refractory temporal lobe epilepsy
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Refractory Status Epilepticus Successfully Treated with the Neurocybernetic System to Stimulate the Vagus Nerve
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Adult-derived neural stem cells differentiate mainly towards astrocytes upon transplantation in the sclerotic hippocampus of a model for temporal lobe epilepsy
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Low dose, whole brain radiation suppresses hippocampal neurogenesis and accelerates kindling epileptogenesis
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Neurosurgical aspects of temporal deep brain stimulation for epilepsy.
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Neurosurgical aspects of temporal deep brain stimulation for epilepsy
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Anatomical and physiological basis and mechanism of action of neuromodulation for epilepsy
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Clinical experience with vagus nerve stimulation and deep brain stimulation in epilepsy
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Amygdalohippocampal deep brain stimulation for refractory temporal lobe epilepsy
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Vagus nerve stimulation for refractory epilepsy: a Belgian multicenter study
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Serial day rapid kindling is an effective tool in screening the anti-epileptic properties of topiramate
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Measuring compound action potentials (CAPS) verifies vagus nerve stimulation (VNS) in rats
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Prospective screening of migraine criteria in Belgian patients with epilepsy
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Levetiracetam: The profile of a novel anticonvulsant drug - Part I: Preclinical data
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Levetiracetam: Part II, the clinical profile of a novel anticonvulsant drug
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Analysis of initial slow waves (ISWs) at the seizure onset in patients with drug resistant temporal lobe epilepsy
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- Journal Article
- A1
- open access
Cell therapy in models for temporal lobe epilepsy
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Vagus nerve stimulation induced changes in corticosterone in rats
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Vagus nerve stimulation for refractory status epilepticus
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Comparison of high and low frequency hippocampal deep brain stimulation in kindled rats
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Serial day rapid kindling is an effective tool in screening the anti-epileptic properties of topiramate