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Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models
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Nieuwe inzichten betreffende metastasen
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Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo
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Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research
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Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts
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Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF1R activation
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When neighbors talk : colon cancer cell invasion and tumor microenvironment myofibroblasts
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Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth
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- Journal Article
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ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer
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A JAK3/STAT3 passenger activation in a lapatinib-acquired resistance model of HER2-amplified breast cancer
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- Journal Article
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Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs
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- Journal Article
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Insights into the myosin II inhibitory potency of A-ring-modified (S)-blebbistatin analogs
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- Journal Article
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Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor
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- Journal Article
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Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties
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Discovery of anti-invasive tools and leads for the study and treatment of metastatic cancer : two case studies
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Discovery and development of new anti-invasive agents, an unmet clinical need
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- Conference Paper
- C3
- open access
NewTumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells
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- Conference Paper
- C3
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The effects of quorum sensing peptides on colon cancer cells: implications for the role of the gut microbiome
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- Journal Article
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Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts
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- Journal Article
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Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions : in vitro and in vivo characterization
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Quantitative evaluation of single cell spread on collagen matrices
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Radiation-induced collateral damage : impact on metastasis
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Discovery of novel nonmuscle myosin II inhibitors as chemical tools and antimetastatic therapeutics leads
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Discovery of novel nonmuscle myosin II inhibitors as antimetastatic therapeutics leads and chemical tools
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- Journal Article
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Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments
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Dissemination and adhesion of peritoneal cancer cells to the peritoneal wall
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4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model
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4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent : from discovery to initial validation in an in vivo metastasis model
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Pharmacological evaluation of the anti-invasive agent 4-fluoro-3',4',5'-trimethoxychalcone
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4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model
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Quantitative and functional requirements for bioluminescent cancer models
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Chick heart invasion assay for testing the invasiveness of cancer cells and the activity of potentially anti-invasive compounds
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Glucocorticoids and the non-steroidal selective glucocorticoid receptor modulator, compound A, differentially affect colon cancer-derived myofibroblasts
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8-prenylnaringenin and tamoxifen inhibit the shedding of irradiated epithelial cells and increase the latency period of radiation-induced oral mucositis
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- Journal Article
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Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?
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4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model
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- Journal Article
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- open access
Effects of irradiation on epithelial wound healing and microbial diversity in an in-vitro oral mucosa model
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Structure-activity relationship studies of 4-methylcoumarin derivatives as anticancer agents
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Anti-inflammatory and antioxidant properties of Piper species: a perspective from screening to molecular mechanisms
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The competence of 7,8-diacetoxy-4-methylcoumarin and other polyphenolic acetates in mitigating the oxidative stress and their role in angiogenesis
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- Journal Article
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Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling
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- Journal Article
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Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade
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Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics
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- Journal Article
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Data on in vivo selection of SK-OV-3 Luc ovarian cancer cells and intraperitoneal tumor formation with low inoculation numbers
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- Conference Paper
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Communication of quorum sensing peptides with breast cancer cells
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Further studies on anti-invasive chemotypes: an excursion from chalcones to curcuminoids
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- Journal Article
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- open access
The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro
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Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells
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Crosstalk between the microbiome and cancer cells by quorum sensing peptides
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Combination of dexamethasone with the selective glucocorticoid receptor modulator, Compound A, does not enhance glucocorticoid responsiveness in lymphoid malignancies
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Impact of neoadjuvant therapy on cancer-associated fibroblasts in rectal cancer
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- Journal Article
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Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer
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The serum estradiol concentration is the main determinant of the estradiol concentration in normal breast tissue
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Combined inhibition of rho-associated protein kinase and EGFR suppresses the invasive phenotype in EGFR-dependent lung cancer cells
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Stromal protein expression in breast cancer is differentially regulated by TGF-β1
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- Journal Article
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Dynamic shifts in the oral microbiome during radiotherapy
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Single cell and spheroid collagen type I invasion assay
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- Journal Article
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Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
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Development of an oral mucosa model to study host-microbiome interactions during wound healing
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- Journal Article
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Sub-emetic toxicity of Bacillus cereus toxin cereulide on cultured human enterocyte-like Caco-2 cells
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Cancer-associated adipose tissue promotes breast cancer progression by paracrine Oncostatin M and Jak/STAT3 signaling
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DFT/B3LYP calculated bond-dissociation enthalpies, radical-scavenging and antioxidant activities of natural-like coumarins
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Carcinoma-associated fibroblasts provide operational flexibility in metastasis
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Modifications of cell signalling and redox balance by targeting protein acetylation using natural and engineered molecules: implications in cancer therapy
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On the quest for new anti-invasive agents: from the discovery of 4-fluoro-3',4','5'-trimethoxychalcone to its initial validation in an in vivo metastasis model
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- Conference Paper
- C3
- open access
How does the human microbiome affect cancer outcome?
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- Conference Paper
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Quorum sensing peptides: missing link between microbiome and health?
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An immunogen synthesis strategy for the development of specific anti-deoxynivalenol monoclonal antibodies
(2014) FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT. 31(10). p.1751-1759 -
- Conference Paper
- C3
- open access
Crosstalk between mammalian cells and the microbiome through quorum sensing peptides, influencing cancer metastasis
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- Journal Article
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Heterologous screening of hybridomas for the development of broad-specific monoclonal antibodies against deoxynivalenol and its analogues
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- Journal Article
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The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
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Mesenchymal stem cell secreted platelet derived growth factor exerts a pro-migratory effect on resident Cardiac Atrial appendage Stem Cells
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The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
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Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1
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- Journal Article
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- open access
On-chip light sheet illumination enables diagnostic size and concentration measurements of membrane vesicles in biofluids
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Micro-particle encapsulated carcinoma-associated fibroblast (CAF) deceive and redirect disseminated cancer cells
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Cancer-associated adipose tissue promotes breast cancer progression by paracrine Oncostatin M and JAK3/STAT3 signaling
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Cell aggregation assays
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Chick heart invasion assay
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- Journal Article
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- open access
The HMI™ module: a new tool to study the host-microbiota interaction in the human gastrointestinal tract in vitro
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- Journal Article
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Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion
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ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type
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Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression
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Unraveling the mechanisms behind the enhanced MTT conversion by irradiated breast cancer cells
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Vacuolar H+ ATPase expression and activity is required for Rab27B dependent invasive growth and metastasis of breast cancer
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Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling
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Assessment of the antineoplastic potential of chalcones in animal models
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Radiation-induced myosin IIA expression stimulates collagen type I matrix reorganization
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Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer
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- Journal Article
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Frondoside A suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis
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Rab27B-mediated metabolic reprogramming induces secretome acidification and chemoresistance in breast cancer cells
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CAF-encapsulated mico-particels capture free cancer cells from the peritoneal fluid
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- Journal Article
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- open access
The in ovo CAM-assay as a xenograft model for sarcoma
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Protein secretome analysis of evolving and responding tumor ecosystems
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Targeted liposome-loaded microbubbles for cell-specific ultrasound-triggered drug delivery
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Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes
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- Journal Article
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Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation
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Angiopoietin-like protein 4 : health effects, modulating agents and structure-function relationships
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Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review
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- Journal Article
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N-Cadherin in neuroblastoma disease : expression and clinical significance
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Prenylated chalcone xanthohumol associates with histones in breast cancer cells: a novel target identified by a monoclonal antibody
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Tumor grafts derived from sarcoma patients retain tumor morphology, viability, and invasion potential and indicate disease outcomes in the chick chorioallantoic membrane model
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DNA methylation-based biomarkers in serum of patients with breast cancer
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An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
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Soy consumption during menopause
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Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchyinal transition
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- Journal Article
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Development of a nanocrystalline Paclitaxel formulation for HIPEC treatment
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Rab27B, an ex(o)citing driver of breast cancer growth, invasion and metastasis
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Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues
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- Conference Paper
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- open access
(Q)SAR directed design, synthesis and evaluation of anti-invasive chalcones and analogues
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QSAR directed design, synthesis and evaluation of anti-invasive chalcones and analogues
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Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues
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Multi-targeting the ERBB receptors may overcome EGFR-T790M-mediated resistance to tyrosine kinase inhibitors
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An immobilized antibody targeting N-cadherin facilitates spread of N-cadherin-positive tumour cells
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- Conference Paper
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- open access
Microbial reuterin production and its effects on a 3-D model of colonic epithelium
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The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells
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Rab27B, een biomarker voor ER-positieve borsttumoren met slechte prognose?
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Rab27B, een biomarker voor ER-positieve borsttumoren met slechte prognose?
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Experimental procedures to assay invasion-associated activities of primary cultured fibroblasts
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De invloed van fysieke activiteit, BMI en insulinemetabolisme op het risico op borstkanker bij de postmenopauzale vrouw
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Production of monoclonal antibodies against hop-derived (Humulus lupulus L.) prenylflavonoids and the development of immunoassays
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Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells
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The tumor ecosystem regulates the roads for invasion and metastasis
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Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts
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Developmental and cancer research on the mammary gland nowadays: preface
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Het metabolisme van de kankercel en van de patiënt met kanker
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Invasie en metastasering
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Diagnostiek en prognose van kanker
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From the laboratory to the patient and back: an interview with Marc Mareel
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- Conference Paper
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- open access
Adipose tissue in breast cancer : not an idle bystander but an active participant in breast cancer progression
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P-cadherin in adhesion and invasion: opposite roles in colon and bladder carcinoma
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EGFR in melanoma : clinical significance and potential therapeutic target
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P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice
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Bacterial modulation of the fasting-induced adipose factor (FIAF): an example of host-microbe crosstalk related to obesity
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Adherence and viability of intestinal bacteria to differentiated Caco-2 cells quantified by flow cytometry
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Bacterial monocultures, propionate, butyrate and H(2)O(2) modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines
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Bioavailability of hop-derived iso-α-acids and reduced derivatives
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The role of myofibroblasts in communicating tumor ecosystems
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Modeling and quantification of cancer cell invasion through collagen type I matrices
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Disposition of soy isoflavones in normal human breast tissue
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Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis
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The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562
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- Journal Article
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Resident and bone marrow-derived mesenchymal stem cells in head and neck squamous cell carcinoma
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Direct Effects of Delta Opioid Receptor Agonists on Invasion-associated Activities of HCT-8/E11 Colon Cancer Cells
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Transport of hop bitter acids across intestinal Caco-2 cell monolayers
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- Journal Article
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- open access
P-cadherin counteracts myosin II-B function : implications in melanoma progression
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Disposition of hop prenylflavonoids in human breast tissue
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An ex(o)citing machinery for invasive tumor growth
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- Journal Article
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- open access
The secretory small GTPase Rab27B as a marker for breast cancer progression
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Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells
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Opioids affect focal contact-mediated cell-substrate adhesion
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From clinical observations of intensity-modulated radiotherapy to dedicated in vitro designs
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Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells
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- Journal Article
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The NF-κB inhibitor IκBα negates colon cancer cell migration, invasion, proliferation and tumor growth
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The secretory GTPase RAB27b drives poor prognosis in ER alpha-positive breast cancer
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Microbial and dietary factors associated with the Equol and 8-prenylnaringenin producer phenotypes
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- Conference Paper
- C3
- open access
Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents
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Microbial activation of mixtures of isoflavones, prenylflavonoids and lignans
(2009) -
TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness
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The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment
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- Journal Article
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- open access
Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells
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Cell aggregation on agar as an indicator for cell-matrix adhesion: effects of opioids
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Peritoneal minimal residual disease in colorectal cancer: mechanisms, prevention, and treatment
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Development of in vitro models for investigating spatially fractionated irradiation: physics and biological results
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Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia
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In vitro cytotoxicity of paclitaxel/β-cyclodextrin complexes for HIPEC
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Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia
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Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53
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Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents
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The secretory small GTPase Rab27B regulates invasive tumor growth and metastasis through extracellular heat shock protein 90 alpha
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A prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts
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Plant polyphenolics as anti-invasive cancer agents
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- Conference Paper
- C3
- open access
Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents
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The microbial PhIP metabolite 7-hydroxy-5-methyl-3-phenyl-6,7,8,9-tetrahydropyrido[3 ',2 ': 4,5]imidazo[1,2-a]pyrimidin-5-ium chloride (PhIP-M1) induces DNA damage, apoptosis and cell cycle arrest towards Caco-2 cells
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Stromal myofibroblasts are drivers of invasive cancer growth
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Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers
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Antioxidant, antiinflammatory and antiinvasive activities of biopolyphenolics
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Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents
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Differential impact of TGF-β and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion
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Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells
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Enhancement of PDGF-BB mitogenic activity on human dermal fibroblasts by biospecific dextran derivatives
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Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
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Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front
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Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells
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The prenylated chalcone xanthohumol induces unfolded protein response, autophagy, and cell death in breast cancer cells by proteasome inhibition
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- Journal Article
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Cellular uptake of soy-derived phytoestrogens in vitro and in human whole blood
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- Journal Article
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Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women
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- Journal Article
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Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women
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- Conference Paper
- C3
- open access
QSAR directed design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds
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Microbial and dietary factors associated with the equaol and 8-prenylnaringenin poducer phenotypes
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A possible mechanism of peritoneal pH changes during carbon dioxide pneumoperitoneum
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- Journal Article
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- open access
Lipoplex-loaded microbubbles for gene delivery: A Trojan horse controlled by ultrasound
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Estrogen receptor signaling is an unstable feature of the gonadotropic LβT2 cell line
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A possible mechanism of peritoneal pH changes during carbon dioxide pneumoperitoneum
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Cell motility and breast cancer metastasis.
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Role of adhesion molecules in locoregional cancer spread.
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The anti-invasive and proapoptotic effect of xanthohumol: potential use in cancer.
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The endoplasmic reticulum: A target for new anticancer drugs
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Xanthohumol induces in vitro apoptosis in B-CLL cells mediated by non-classical ER stress
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- Journal Article
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Estrogen receptor alpha (ER alpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alpha T3-1 cell line
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The tandem PDZ domains of syntenin promote cell invasion
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Soluble cadherins as cancer biomarkers
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Intestinal bacteria play a crucial role in the carcinogenic risk from 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
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Akt1 & 2 depletion by RNA interference reduced tumor growth and invasion in human colon cancer cells
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Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro
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Xanthohumol: a new potential proteasome inhibitor that activates the pro-apoptotic arm of the unfolded protein response in B-CLL cells
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Colon cancer cells: pro-invasive signalling
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Bioavailability of phytoestrogens from soy and hops
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Exploring the 8-PN producer phenotype: an intervention trial with 50 healthy post-menopausal Caucasian women
(2006) -
Exploring the equol producer phenotype: an intervention trial with 100 healthy post-menoapausal Caucasian women
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ARE PHYTOESTROGENS OF ANY HELP
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The extracellular fragment of N-cahderin stimulates angiogenesis and migration and invasion of cells
(2006) -
Tumour markers in andrology
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Growth factor modulation of fibroblast proliferation, differentiation, and invasion: Implications for tissue valve engineering
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Anti-invasive and anti-metastasis strategies: New roads, new tools and new hopes
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Soluble N-cadherin in human biological fluids
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QSAR modeling of anti-invasive activity of organic compounds using structural descriptors
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Differences in tumor-associated protein levels among middle-age Flemish women in association with area of residence and exposure to pollutants
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A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts
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- Journal Article
- A1
- open access
Soluble N-cadherin fragment promotes angiogenesis
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Induction of the adenoma-carcinoma progression and Cdc25A-B phosphatases by the trefoil factor TFF1 in human colon epithelial cells
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Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric G alpha/G beta gamma protein complex
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Tibolone and its metabolites inhibit invasion of human mammary carcinoma cells in vitro
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P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanoma
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Epithelial-mesenchymal transitions in human cancer
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Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation
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Nerve Growth Factor mediates its pro-invasive effect in parallel with the release of a soluble E-cadherin fragment from breast cancer MCF-7/AZ cells
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The cancer chemopreventive agent resveratrol induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities
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Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment
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STAT3, TFF3, VEGFR in colon cancer cells (vol 65, pg 165, 2005)
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A safety study of oral tangeretin and xanthohumol administration to laboratory mice
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Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism
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Molecular targets of growth, differentiation, tissue integrity, and ectopic cell death in cancer cells
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Tibolone and its metabolites inhibit invasion of human mammary carcinoma cells in vitro
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Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer
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New anti-invasive compounds: Results from the Indo-Belgian screening program
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A proteomic approach to understand the anti-invasive and pro-apoptotic effect of xanthohumol in human breast cancer cells
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Unrecognized or potential risk factors for childhood cancer
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Bowes melanoma cells secrete heregulin, which can promote aggregation and counteract invasion of human mammary cancer cells
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Xanthohumol induces apoptosis in B-CLL mediated by caspase 9 following downregulation of bcL-xL and mcl-1
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P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells
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Soluble N-cadherin fragments: a new indicator of invasion. Vol. 59(2)
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Cellular activities related to growth and invasion: targets for flavonoids
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Dual activities of galectin-3 in human prostate cancer: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3
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N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling
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A reproducible animal model of colon cancer with a solitary neoplastic growth
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Distribution of soy-derived phytoestrogens in human breast tissue and biological fluids
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Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding
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CXCL-12 induces prolonged erk-phosphorylation in Zap-70 positive B-CLL
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Alpha-catenin is required for IGF-I-induced cellular migration but not invasion in human colonic cancer cells