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- 2018
- DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients
- Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project)
- DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
- Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project)
- 2017
- Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses
- ERS technical standard on bronchial challenge testing : general considerations and performance of methacholine challenge tests
- microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients : a translational approach
- Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease
- Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure
- Digital health to end tuberculosis in the Sustainable Development Goals era : achievements, evidence and future perspectives
- Role of tumor necrosis factor-α and its receptors in diesel exhaust particle-induced pulmonary inflammation
- Inhaled treatment of COPD : a Delphi consensus statement
- European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases: report of the European Union Parliament Summit (29 March 2017)
- MicroRNA profiling reveals a role for microRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease
- Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma
- Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis : a EUFOREA-ARIA-EPOS-AIRWAYS ICP statement
- Taken to task : what is and is not an appropriate response to an ERS guidelines task force?
- EUFOREA Rhinology Research Forum 2016 : report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis
- CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis : a SUNFRAIL report
- Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps
- 2016
- Inhalatiecorticosteroïden in combinatie met formoterol als onderhouds- en aanvalsbehandeling bij mild tot matig persistente astma
- Efficacy of tiotropium-olodaterol fixed-dose combination in COPD
- ARIA 2016 : care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
- Epidemiology of chronic bronchitis in chronic obstructive pulmonary disease (COPD)
- The European Respiratory Society evaluates its 2013-2018 strategic plan implementation
- Asthma inflammatory phenotypes show differential microRNA expression in sputum
- Characterization and quantification of innate lymphoid cell subsets in human lung
- Chronic obstructive pulmonary disease and the risk of stroke: the Rotterdam study
- Microrna-218-5p is implicated in the pathogenesis of chronic obstructive pulmonary disease
- Pro- and anti-inflammatory role of ChemR23 signaling in pollutant-induced inflammatory lung responses
- Aggravation of allergic airway inflammation by cigarette smoke in mice is CD44-dependent
-
Risk of frailty in elderly with COPD : a population-based study
(2016) JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 71(5). p.689-695 Mark
- Prof. dr. Marcel Van Der Straeten (12 september 1924-3 december 2015)
- European symposium on precision medicine in allergy and airways diseases: report of the European Union Parliament symposium (October 14, 2015)
- Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
- LncRNAs in the context of Chronic Obstructive Pulmonary Disease (COPD) are associated to immune response and metabolism of xenobiotics
- Rol van microRNA in neutrofiel astma
- 2015
- Transforming growth factor-β superfamily in obstructive lung diseases: more suspects than TGF-β alone
- Identification of differentially expressed microRNAs in neutrophilic asthma
- De Europese COPD-audit 2011: positie van België in Europa op het vlak van COPD-zorg
- Effects of whole body vibration in patients with COPD
- A chest physician's guide to mechanisms of sinonasal disease
- Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study
- La thermoplastie bronchique dans le traitement de l'asthme sévère de l'adulte
- A randomised, double-blind, four-way, crossover trial comparing the 24-h FEV₁ profile for once-daily versus twice-daily treatment with olodaterol, a novel long-acting β₂-agonist, in patients with chronic obstructive pulmonary disease
- European symposium on precision medicine in allergy and airways diseases: report of the European Union parliament symposium (October 14, 2015)
- The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice
- Is there still hope for single therapies: how do we set up experimental systems to efficiently test combination therapies?
- Airway surface dehydration aggravates cigarette smoke-induced hallmarks of COPD in mice
- Gait patterns in COPD : the Rotterdam Study
- Role of B cell-activating factor in chronic obstructive pulmonary disease
- 2014
- Role of activin-A in cigarette smoke-induced inflammation and COPD
- Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults
- The European Respiratory Society plans its future: the 2013-2018 strategic plan
- Cause-specific mortality in mild COPD : the Rotterdam study
- Is there a role for macrolides in severe asthma?
- Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice
- Integrated care pathways for airway diseases (AIRWAYS-ICPs)
- A rare cause of haemoptysis
- Heterogeneity of phenotypes in severe asthmatics: the Belgian Severe Asthma Registry (BSAR)
- The relation of airway obstruction to asthma, chronic rhinosinusitis and age: results from a population survey of adults
- 2013
- Spirometric reference values for an East-African population
- Chronic obstructive pulmonary disease and cerebral microbleeds: the Rotterdam study
- Hand-held fractional exhaled nitric oxide measurements as a non-invasive indicator of systemic inflammation in Crohn's disease
- The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling
- Volatile organic compounds in the breath of cystic fibrosis patients: a pilot phase
- Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease
- Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study
- Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial
- Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study
- Statins, systemic inflammation and risk of death in COPD: the Rotterdam Study
- Short cigarette smoke exposure facilitates sensitisation and asthma development in mice
- The role of soluble guanylyl cyclase in Chronic Obstructive Pulmonary Disease
- Chronic obstructive pulmonary disease (COPD) exacerbations and carotid artery plaques : the Rotterdam study
- Contribution of four common pulmonary function tests to diagnosis of patients with respiratory symptoms : a prospective cohort study
- Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases
- Frailty affects quality of spirometry : the Rotterdam study
- 2012
- COPD is associated with reduced pulmonary interstitial expression of pentraxin-3
- European position paper on rhinosinusitis and nasal polyps 2012
- Gebruik van interferon-gamma-'release assays' voor het opsporen van latente tuberculose
- Monocyte-derived dendritic cell recruitment and allergic TH2 responses after exposure to diesel particles are CCR2 dependent
- Aclidinium bromide for the treatment of chronic obstructive pulmonary disease
- EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012: a summary for otorhinolaryngologists
- Targeting interleukin-4 in asthma : lost in translation?
- 2011
- Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation
- Directing the future of lung health: the European Respiratory Roadmap
- Interleukin 6 (IL6) plasma levels, common variation In the IL6 gene and the risk of chronic obstructive pulmonary disease : a prospective population-based cohort study
- MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease
- Neomacrolides in the treatment of patients with severe asthma and/or bronchiectasis: a retrospective observational study
- NLRP3/Caspase-1-independent IL-1β production mediates diesel exhaust particle-induced pulmonary inflammation
- (Ex-)smoking asthma patients in general and specialized Belgian practice
- New insights into the immunology of chronic obstructive pulmonary disease
- Gene therapy for allergic diseases
- Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
- The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation
- Tiotropium bromide protects against methacholine, but not against neurokin A-induced bronchoconstriction in patients with Asthma: a randomized, double-blind, placebo-controlled, crossover study
- Prevalence of atopy, asthma and COPD in an urban and a rural area of an African country
- Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD
- Mendelian randomization study of interleukin-6 in chronic obstructive pulmonary disease
- 2010
- The impact of concomitant rhinitis on asthma-related quality of life and asthma control
- Pulmonary rehabilitation for interstitial lung disease: response
- Effect of salmeterol/fluticasone propionate combination on airway hyper-responsiveness in patients with well-controlled asthma
- Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD
- Reduced expression of pentraxin-3 in the lungs of patients with COPD
- Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice
- Bronchodilatory effects of aclidinium bromide, a long-acting muscarinic antagonist, in COPD patients
- Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD
- Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study
- A new danger in the air: how pulmonary innate immunity copes with man-made airborne xenobiotics
- Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice
- Prioritised research agenda for prevention and control of chronic respiratory diseases
- Different regulation of cigarette smoke induced inflammation in upper versus lower airways
- Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner
- Effects of pulmonary rehabilitation in patients with restrictive lung diseases
- Selective accumulation of Langerhans-type dendritic cells in small airways of patients with COPD
- Activity of aclidinium bromide, a new long-acting muscarinic antagonist: a phase I study
- Increased T-regulatory cells in lungs and draining lymph nodes in a murine model of COPD
- The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease
- Inflammatory Airways Diseases and Clinical Allergy Assembly contribution to the celebration of 20 years of the ERS
- GINA en GOLD, een update
- Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation
- Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease
- Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells
- 2009
- Effects of ciclesonide and fluticasone on cortisol secretion in patients with persistent asthma
- Between a cough and a wheeze: dendritic cells at the nexus of tobacco smoke-induced allergic airway sensitization
- Prevalence, incidence and lifetime risk for the development of COPD in the elderly . The Rotterdam study
- C-reactive protein levels, haplotypes and the risk of incident chronic obstructive pulmonary disease
- Different regulation of cigarette smoke induced inflammation in upper versus lower airways: findings from a mouse model
- A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-alpha Blockade in Severe Persistent Asthma
- The Role of Dendritic Cells in the Pathogenesis of COPD: Liaison Officers in the Front Line
- CCR7 Modulates Pulmonary and Lymph Node Inflammatory Responses in Cigarette Smoke-Exposed Mice
- Concomittant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way
- Comparison of Acute Inflammatory and Chronic Structural Asthma-Like Responses between C57BL/6 and BALB/c Mice
- Role of Lymphotoxin (alpha) in Cigarette Smoke-Induced Inflammation and Lymphoid Neogenesis
- Role of tachykinin NK1 receptor in a murine model of cigarette-smoke induced pulmonary inflammation
- Current and future use of the mannitol bronchial challenge in everyday clinical practice
- Decreased FOXP3 protein expression in patients with asthma
- A comparison of budesonide/formoterol maintenance and reliever therapy vs conventional best practice in asthma management
- Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure
- 2008
- Behandeling van het maligne pleuramesothelioom.
- Chronic inflammation in asthma: a contest of persistence vs resolution
- The relation between paracetamol use and asthma: a GA²LEN European case-control study
- Bronchodilating effect of combined therapy with ipratropium bromide and ondasetron in patients with COPD
- TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice
- De rol van adjuvante chemotherapie bij volledig gereseceerde niet-kleincellige longkanker.
- Comment on "cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent"
- The effect of the leukotriene receptor antagonist zafirlukast on neurokinin-A-induced bronchoconstriction in patients with asthma. A comparison with leukotriene D-4 induced bronchoconstriction
- Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance
- A case-control study of the relation between plasma selenium and asthma in European populations: a GA(2)LEN project
- 2007
- Are beta(2)-agonists safe in patients with acute exacerbations of COPD?
- Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease
- Pulmonary dendritic cells: playing ball in the BAL?
- Severe asthma in adults: What are the important questions?
- Interstitiële longafwijkingen bij reumatoide artritis
- Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice
- Role of the tachykinin NK1 receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea
- Comment on 'A novel pathway that regulates inflammatory disease in the respiratory tract'
- Cross-sectional exploration of upper airway status in an asthmatic population
- COPD treatment strategies
- Prolonged inhaled allergen exposure can induce persistent tolerance
- Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation.
- Dendritic cell maturity and obstructive airway disease
- 2006
- Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema
- The role of immune tolerance in asthma pathogenesis
- Extending the understanding of sensory neuropeptides
- Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms
- Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation
- The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma
- Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice
- Murine models of COPD
- Animal models of allergen-induced tolerance in asthma: are T-regulatory-1 cells (Tr-1) the solution for T-helper-2 cells (Th-2) in asthma?
- Cigarette smoke exposure facilitates allergic sensitization in mice
- Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema
- Elevated MMP-12 protein levels in induced sputum from patients with COPD
- 2005
- Positioning of glucocorticosteroids in asthma and allergic rhinitis guidelines (versus other therapies)
- Short-term cigarette smoke exposure enhances allergic airway inflammation in mice
- Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?
- Time course of cigarette smoke-induced pulmonary inflammation in mice
- De vuurspuwerslong: een bijzondere casus van aspiratiepneumonitis
- Indirect bronchial hyper-responsiveness: the coming of age of a specific group of bronchial challenges
- Oordeel en houding van de huisarts bij chronisch obstructieve longziekten
- 2004
- Roken en astma
- The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma
- Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients
- 2003
- Tiotropium bromide: a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease
- Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea
- The role of neural inflammation in asthma and chronic obstructive pulmonary disease
- Bronchial hyperresponsiveness: too complex to be useful?
- Indirect airway challenges
- 2002
- Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma.
- Effect of ozone exposure on allergic sensitization and airway inflammation induced by dendritic cells.
- 2001
- Do measures of bronchial responsiveness add information in diagnosis and monitoring of patients with asthma?
- Tachykinin receptor antagonists: potential in airways disease.
- Airway inflammation and tachykinins: prospects for the development of tachykinin receptor antagonists.
- Allergische aandoeningen
- The role of neuroeffector mechanisms in the pathogenesis of asthma.
- 2000
- Indirect bronchial hyperresponsiveness in asthma: mechanisms pharmacology and implications for clinical research.
- Potential usefulness of inhibiting neural mechanisms in asthma.
- Neural mechanisms in difficult asthma
- Role of tachykinins in asthma.
- Neural mechanisms in asthma.
- Pro-inflammatory effects of substance P : new perspectives for the treatment of airway diseases?
- 1999
- Difficult/therapy-resistant asthma - The need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies.
- The cellular composition of induced sputum in chronic obstructive pulmonary disease.
- Ambient ozone concentrations induce airway hyperresponsiveness in some rat strains.
- Leerboek Longziekten /
- A randomized study comparing vincristine, adriamycin, cyclophosphamide (VAC) to carboplatin, etoposide (CE) in previously untreated small cell lung cancer (SCLC).
-
New therapeutic developments in COPD
(1999) CURRENT OPINION IN CARDIOVASCULAR, PULMONARY AND RENAL INVESTIGATIONAL DRUGS. 1(4). p.491-499 Mark
- Bijzondere vormen van longembolie.
- Mast cell stabilizing drugs.
- Role of 5-HT1A receptors in the activation of sensory nerves by capsaicin.
- Tachykinin receptor antagonists.
- Presence of substance P and neurokinin 1 receptors in human sputum macrophages and U-937 cells.
- Perioperatieve evaluatie en zorg.
- Role of tachykinins as contractile agonists of human airways in asthma.
- Lung antigen presenting cells are an important source of substance P in allergic airway inflammation.
- Pleuravocht: diagnose en therapeutische benadering.
- Bronchodilatantia.
- Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation
- Astma bij volwassenen.
- The effects of inhaled fluticasone propionate on metha-choline - And neurokinin A-induced bronchoconstriction in asthmatics.
- Effect of ozone exposure on the pulmonary immune response induced by dendritic cells.
- Pijnbestrijding en palliatie.
- 1998
- Provocatietests
- Pre- en postoperatieve evaluatie
- Modulation by 5-HT1A receptors of the 5-HT2 receptor-mediated tachykinin-induced contraction of the rat trachea in vitro.
- The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics.
- Longkanker: van moleculaire biologie tot gecombineerde behandelingsmodaliteiten.
- Inhalatietherapie voor asthma: ja, maar hoe?
- Regionally different influence of contractile agonists on isolated rat airway segments.
- 1997
- Serum neuron-specific enolase as a tumor marker in the diagnosis and follow-up of small-cell lung cancer.
- Follow-up van longkanker
- Respiratoire effecten van ozon.
- Role of IFN-gamma in the inhibition of the allergic airway inflammation caused by IL-12.
- Animal models for studying genetics of asthma
- The effect of ABT-761, a novel 5-lipoxygenase inhibitor, on exercise- and adenosine-induced bronchoconstriction in asthmatic subjects.
- Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro.
- Role of the 5-HT receptor in neurogenic inflammation in Fisher 344 rat airways.
- 1996
- Value of rigid bronchoscopy and cytodiagnosis of bronchial washings in detecting bronchial carcinoma in the presence of a carcinoma of the upper aerodigestive tract.
- Adenosine receptors involved in the bronchoconstrictor effect of adenosine.
- Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice.
- Actuele trends in de behandeling van het kleincellig bronchuscarcinoom.
- The effect of inhaled FK224, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics.
- Thymoma: het onverwachte recidief
- Clinical studies on the airway effects of sensory neuropeptides
- Second primary lung cancer in Flanders : frequency, clinical presentation, treatment and prognosis
- Epidemiologie van longkanker
- 1995
- GENETIC-CONTROL OF INDIRECT AIRWAY RESPONSIVENESS IN THE RAT.
- Characterization of the neurogenic plasma extravasation in the airways
- CHARACTERIZATION OF NEUROGENIC INFLAMMATION IN THE AIRWAYS OF 2 HIGHLY INBRED RAT STRAINS.