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Insights in particulate matter-induced allergic airway inflammation : focus on the epithelium
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DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients
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Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project)
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Barriers and facilitators on early integration of palliative home care for people with severe COPD : a focus group study
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Rhinology future debates 2017 by EUFOREA : novel treatments and surgical solutions in rhinology
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- journalArticle
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- open access
'A palliative end-stage COPD patient does not exist' : a qualitative study of barriers to and facilitators for early integration of palliative home care for end-stage COPD
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- journalArticle
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- open access
Development of a complex intervention for early integration of palliative home care into standard care for end-stage COPD patients : a phase 0-I study
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Optimising experimental research in respiratory diseases : an ERS statement
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Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses
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ERS technical standard on bronchial challenge testing : general considerations and performance of methacholine challenge tests
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- journalArticle
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microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients : a translational approach
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- journalArticle
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- open access
Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease
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Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure
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MicroRNA profiling reveals a role for microRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease
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Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis : a EUFOREA-ARIA-EPOS-AIRWAYS ICP statement
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Taken to task : what is and is not an appropriate response to an ERS guidelines task force?
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EUFOREA Rhinology Research Forum 2016 : report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis
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- journalArticle
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Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma
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- journalArticle
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Role of tumor necrosis factor-α and its receptors in diesel exhaust particle-induced pulmonary inflammation
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- journalArticle
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Inhaled treatment of COPD : a Delphi consensus statement
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- journalArticle
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European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases : report of the European Union Parliament Summit (29 March 2017)
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The role of dicer in alveolar macrophages and dendritic cells in smoke-induced inflammation
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Digital health to end tuberculosis in the Sustainable Development Goals era : achievements, evidence and future perspectives
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Sex-differences in mortality within the COPD chronic bronchitis phenotype
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- journalArticle
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CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis : a SUNFRAIL report
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Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps
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Inhalatiecorticosteroïden in combinatie met formoterol als onderhouds- en aanvalsbehandeling bij mild tot matig persistente astma
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- journalArticle
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- open access
ARIA 2016 : care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
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Epidemiology of chronic bronchitis in chronic obstructive pulmonary disease (COPD)
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- journalArticle
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- open access
Efficacy of tiotropium-olodaterol fixed-dose combination in COPD
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Risk of frailty in elderly with COPD : a population-based study
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LncRNAs in the context of Chronic Obstructive Pulmonary Disease (COPD) are associated to immune response and metabolism of xenobiotics
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European symposium on precision medicine in allergy and airways diseases: report of the European Union Parliament symposium (October 14, 2015)
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- journalArticle
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- open access
Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
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Prof. dr. Marcel Van Der Straeten (12 september 1924-3 december 2015)
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Chronic obstructive pulmonary disease and the risk of stroke: the Rotterdam study
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Pro- and anti-inflammatory role of ChemR23 signaling in pollutant-induced inflammatory lung responses
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- journalArticle
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Aggravation of allergic airway inflammation by cigarette smoke in mice is CD44-dependent
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- journalArticle
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Characterization and quantification of innate lymphoid cell subsets in human lung
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Microrna-218-5p is implicated in the pathogenesis of chronic obstructive pulmonary disease
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The European Respiratory Society evaluates its 2013-2018 strategic plan implementation
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Asthma inflammatory phenotypes show differential microRNA expression in sputum
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Rol van microRNA in neutrofiel astma
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Transforming growth factor-β superfamily in obstructive lung diseases: more suspects than TGF-β alone
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Identification of differentially expressed microRNAs in neutrophilic asthma
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- journalArticle
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A randomised, double-blind, four-way, crossover trial comparing the 24-h FEV₁ profile for once-daily versus twice-daily treatment with olodaterol, a novel long-acting β₂-agonist, in patients with chronic obstructive pulmonary disease
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- journalArticle
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The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice
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European symposium on precision medicine in allergy and airways diseases: report of the European Union parliament symposium (October 14, 2015)
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La thermoplastie bronchique dans le traitement de l'asthme sévère de l'adulte
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Effects of whole body vibration in patients with COPD
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A chest physician's guide to mechanisms of sinonasal disease
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Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study
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MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation
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De Europese COPD-audit 2011: positie van België in Europa op het vlak van COPD-zorg
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Is there still hope for single therapies: how do we set up experimental systems to efficiently test combination therapies?
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- journalArticle
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Airway surface dehydration aggravates cigarette smoke-induced hallmarks of COPD in mice
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Gait patterns in COPD : the Rotterdam Study
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Role of B cell-activating factor in chronic obstructive pulmonary disease
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Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice
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Is there a role for macrolides in severe asthma?
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Integrated care pathways for airway diseases (AIRWAYS-ICPs)
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A rare cause of haemoptysis
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The European Respiratory Society plans its future: the 2013-2018 strategic plan
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Cause-specific mortality in mild COPD : the Rotterdam study
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- journalArticle
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Bronchial thermoplasty : a new therapeutic option for the treatment of severe, uncontrolled asthma in adults
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Role of activin-A in cigarette smoke-induced inflammation and COPD
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Heterogeneity of phenotypes in severe asthmatics: the Belgian Severe Asthma Registry (BSAR)
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The relation of airway obstruction to asthma, chronic rhinosinusitis and age: results from a population survey of adults
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Spirometric reference values for an East-African population
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Chronic obstructive pulmonary disease and cerebral microbleeds: the Rotterdam study
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Statins, systemic inflammation and risk of death in COPD: the Rotterdam Study
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Short cigarette smoke exposure facilitates sensitisation and asthma development in mice
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The role of soluble guanylyl cyclase in Chronic Obstructive Pulmonary Disease
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Chronic obstructive pulmonary disease (COPD) exacerbations and carotid artery plaques : the Rotterdam study
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Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study
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Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study
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Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial
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Hand-held fractional exhaled nitric oxide measurements as a non-invasive indicator of systemic inflammation in Crohn's disease
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The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling
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- conference
- C3
- open access
Volatile organic compounds in the breath of cystic fibrosis patients: a pilot phase
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Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease
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Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases
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Contribution of four common pulmonary function tests to diagnosis of patients with respiratory symptoms : a prospective cohort study
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Frailty affects quality of spirometry : the Rotterdam study
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COPD is associated with reduced pulmonary interstitial expression of pentraxin-3
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European position paper on rhinosinusitis and nasal polyps 2012
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Monocyte-derived dendritic cell recruitment and allergic TH2 responses after exposure to diesel particles are CCR2 dependent
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EPOS 2012 : European position paper on rhinosinusitis and nasal polyps 2012 : a summary for otorhinolaryngologists
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Targeting interleukin-4 in asthma : lost in translation?
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Aclidinium bromide for the treatment of chronic obstructive pulmonary disease
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Gebruik van interferon-gamma-'release assays' voor het opsporen van latente tuberculose
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Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation
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Directing the future of lung health: the European Respiratory Roadmap
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Interleukin 6 (IL6) plasma levels, common variation In the IL6 gene and the risk of chronic obstructive pulmonary disease : a prospective population-based cohort study
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- journalArticle
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- open access
Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
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- journalArticle
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- open access
Gene therapy for allergic diseases
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NLRP3/Caspase-1-independent IL-1β production mediates diesel exhaust particle-induced pulmonary inflammation
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(Ex-)smoking asthma patients in general and specialized Belgian practice
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New insights into the immunology of chronic obstructive pulmonary disease
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MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease
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Neomacrolides in the treatment of patients with severe asthma and/or bronchiectasis: a retrospective observational study
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The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation
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Tiotropium bromide protects against methacholine, but not against neurokin A-induced bronchoconstriction in patients with Asthma: a randomized, double-blind, placebo-controlled, crossover study
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Mendelian randomization study of interleukin-6 in chronic obstructive pulmonary disease
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Prevalence of atopy, asthma and COPD in an urban and a rural area of an African country
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Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD
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Pulmonary rehabilitation for interstitial lung disease : response
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The impact of concomitant rhinitis on asthma-related quality of life and asthma control
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Effect of salmeterol/fluticasone propionate combination on airway hyper-responsiveness in patients with well-controlled asthma
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Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD
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Reduced expression of pentraxin-3 in the lungs of patients with COPD
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- journalArticle
- A1
- open access
Different regulation of cigarette smoke induced inflammation in upper versus lower airways
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Prioritised research agenda for prevention and control of chronic respiratory diseases
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- journalArticle
- A1
- open access
Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner
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- journalArticle
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- open access
Selective accumulation of Langerhans-type dendritic cells in small airways of patients with COPD
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Activity of aclidinium bromide, a new long-acting muscarinic antagonist: a phase I study
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Effects of pulmonary rehabilitation in patients with restrictive lung diseases
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Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study
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A new danger in the air: how pulmonary innate immunity copes with man-made airborne xenobiotics
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Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice
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Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice
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Bronchodilatory effects of aclidinium bromide, a long-acting muscarinic antagonist, in COPD patients
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Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD
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Inflammatory Airways Diseases and Clinical Allergy Assembly contribution to the celebration of 20 years of the ERS
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Increased T-regulatory cells in lungs and draining lymph nodes in a murine model of COPD
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The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease
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GINA en GOLD, een update
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Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease
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- journalArticle
- A1
- open access
Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation
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Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells
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Effects of ciclesonide and fluticasone on cortisol secretion in patients with persistent asthma
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Comparison of Acute Inflammatory and Chronic Structural Asthma-Like Responses between C57BL/6 and BALB/c Mice
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- journalArticle
- A1
- open access
Role of Lymphotoxin (alpha) in Cigarette Smoke-Induced Inflammation and Lymphoid Neogenesis
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- journalArticle
- A1
- open access
Role of tachykinin NK1 receptor in a murine model of cigarette-smoke induced pulmonary inflammation
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Current and future use of the mannitol bronchial challenge in everyday clinical practice
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Concomittant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way
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A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-alpha Blockade in Severe Persistent Asthma
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The Role of Dendritic Cells in the Pathogenesis of COPD: Liaison Officers in the Front Line
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CCR7 Modulates Pulmonary and Lymph Node Inflammatory Responses in Cigarette Smoke-Exposed Mice
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Prevalence, incidence and lifetime risk for the development of COPD in the elderly : the Rotterdam study
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C-reactive protein levels, haplotypes and the risk of incident chronic obstructive pulmonary disease
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Different regulation of cigarette smoke induced inflammation in upper versus lower airways: findings from a mouse model
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Between a cough and a wheeze: dendritic cells at the nexus of tobacco smoke-induced allergic airway sensitization
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Decreased FOXP3 protein expression in patients with asthma
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A comparison of budesonide/formoterol maintenance and reliever therapy vs conventional best practice in asthma management
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Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure
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Behandeling van het maligne pleuramesothelioom.
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Chronic inflammation in asthma: a contest of persistence vs resolution
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The relation between paracetamol use and asthma: a GA²LEN European case-control study
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TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice
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Bronchodilating effect of combined therapy with ipratropium bromide and ondasetron in patients with COPD
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Comment on "cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent"
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The effect of the leukotriene receptor antagonist zafirlukast on neurokinin-A-induced bronchoconstriction in patients with asthma. A comparison with leukotriene D-4 induced bronchoconstriction
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De rol van adjuvante chemotherapie bij volledig gereseceerde niet-kleincellige longkanker.
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A case-control study of the relation between plasma selenium and asthma in European populations: a GA(2)LEN project
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Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance
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Are beta(2)-agonists safe in patients with acute exacerbations of COPD?
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Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease
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Pulmonary dendritic cells: playing ball in the BAL?
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Comment on 'A novel pathway that regulates inflammatory disease in the respiratory tract'
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Cross-sectional exploration of upper airway status in an asthmatic population
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COPD treatment strategies
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- journalArticle
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Prolonged inhaled allergen exposure can induce persistent tolerance
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Role of the tachykinin NK1 receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea
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Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice
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Severe asthma in adults: What are the important questions?
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Interstitiële longafwijkingen bij reumatoide artritis
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Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation.
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- journalArticle
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- open access
Dendritic cell maturity and obstructive airway disease
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Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema
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The role of immune tolerance in asthma pathogenesis
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Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice
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Murine models of COPD
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Animal models of allergen-induced tolerance in asthma: are T-regulatory-1 cells (Tr-1) the solution for T-helper-2 cells (Th-2) in asthma?
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- journalArticle
- A1
- open access
Cigarette smoke exposure facilitates allergic sensitization in mice
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Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema
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The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma
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Extending the understanding of sensory neuropeptides
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Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms
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Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation
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Elevated MMP-12 protein levels in induced sputum from patients with COPD
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Positioning of glucocorticosteroids in asthma and allergic rhinitis guidelines (versus other therapies)
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Indirect bronchial hyper-responsiveness: the coming of age of a specific group of bronchial challenges
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- journalArticle
- A2
- open access
De vuurspuwerslong: een bijzondere casus van aspiratiepneumonitis
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Time course of cigarette smoke-induced pulmonary inflammation in mice
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- journalArticle
- A1
- open access
Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?
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Short-term cigarette smoke exposure enhances allergic airway inflammation in mice
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Oordeel en houding van de huisarts bij chronisch obstructieve longziekten
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Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients
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Roken en astma
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- journalArticle
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- open access
The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma
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Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea
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Tiotropium bromide : a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease
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The role of neural inflammation in asthma and chronic obstructive pulmonary disease
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Bronchial hyperresponsiveness: too complex to be useful?
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Indirect airway challenges
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Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma.
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Effect of ozone exposure on allergic sensitization and airway inflammation induced by dendritic cells.
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Allergische aandoeningen
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Airway inflammation and tachykinins: prospects for the development of tachykinin receptor antagonists.
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Do measures of bronchial responsiveness add information in diagnosis and monitoring of patients with asthma?
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Tachykinin receptor antagonists: potential in airways disease.
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The role of neuroeffector mechanisms in the pathogenesis of asthma.
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Indirect bronchial hyperresponsiveness in asthma: mechanisms pharmacology and implications for clinical research.
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Potential usefulness of inhibiting neural mechanisms in asthma.
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Neural mechanisms in asthma.
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Role of tachykinins in asthma
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Neural mechanisms in difficult asthma
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Pro-inflammatory effects of substance P : new perspectives for the treatment of airway diseases?
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Leerboek longziekten
HC Hoogsteden, PNR Dekhuijzen, Guy Joos (UGent) and PE Postmus(1999) -
Difficult/therapy-resistant asthma - The need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies.
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The cellular composition of induced sputum in chronic obstructive pulmonary disease.
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Ambient ozone concentrations induce airway hyperresponsiveness in some rat strains.
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A randomized study comparing vincristine, adriamycin, cyclophosphamide (VAC) to carboplatin, etoposide (CE) in previously untreated small cell lung cancer (SCLC).
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Role of tachykinins as contractile agonists of human airways in asthma.
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Lung antigen presenting cells are an important source of substance P in allergic airway inflammation.
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Pleuravocht: diagnose en therapeutische benadering.
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Bronchodilatantia
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Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation
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Tachykinin receptor antagonists.
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Presence of substance P and neurokinin 1 receptors in human sputum macrophages and U-937 cells.
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Perioperatieve evaluatie en zorg
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Bijzondere vormen van longembolie
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Mast cell stabilizing drugs.
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New therapeutic developments in COPD
(1999) CURRENT OPINION IN CARDIOVASCULAR, PULMONARY AND RENAL INVESTIGATIONAL DRUGS. 1(4). p.491-499 -
Role of 5-HT1A receptors in the activation of sensory nerves by capsaicin.
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Astma bij volwassenen.
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Effect of ozone exposure on the pulmonary immune response induced by dendritic cells.
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Pijnbestrijding en palliatie
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The effects of inhaled fluticasone propionate on metha-choline - And neurokinin A-induced bronchoconstriction in asthmatics.
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The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics.
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Modulation by 5-HT1A receptors of the 5-HT2 receptor-mediated tachykinin-induced contraction of the rat trachea in vitro.
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Longkanker: van moleculaire biologie tot gecombineerde behandelingsmodaliteiten.
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Inhalatietherapie voor asthma: ja, maar hoe?
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Provocatietests
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Pre- en postoperatieve evaluatie
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Regionally different influence of contractile agonists on isolated rat airway segments.
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Serum neuron-specific enolase as a tumor marker in the diagnosis and follow-up of small-cell lung cancer.
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Follow-up van longkanker
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Animal models for studying genetics of asthma
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Role of IFN-gamma in the inhibition of the allergic airway inflammation caused by IL-12.
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Respiratoire effecten van ozon.
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Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro.
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The effect of ABT-761, a novel 5-lipoxygenase inhibitor, on exercise- and adenosine-induced bronchoconstriction in asthmatic subjects.
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Role of the 5-HT receptor in neurogenic inflammation in Fisher 344 rat airways.
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Value of rigid bronchoscopy and cytodiagnosis of bronchial washings in detecting bronchial carcinoma in the presence of a carcinoma of the upper aerodigestive tract.
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The effect of inhaled FK224, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics.
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Thymoma: het onverwachte recidief
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Clinical studies on the airway effects of sensory neuropeptides
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Second primary lung cancer in Flanders : frequency, clinical presentation, treatment and prognosis