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Migration of surrogate contaminants from paperboard to foods : effect of food and surrogate properties
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- Journal Article
- A1
- open access
A recycler’s perspective on the implications of REACH and food contact material (FCM) regulations for the mechanical recycling of FCM plastics
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Modelling and validation of the antifungal activity of DL-3-phenyllactic acid and acetic acid on bread spoilage moulds
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Effect of storage temperature, water activity, oxygen headspace concentration and pasteurization intensity on the time to growth of Aspergillus fischerianus (teleomorph Neosartorya fischeri)
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Pharmacokinetics in patients with cystic fibrosis : a systematic review of data published between 1999 and 2019
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Validation of in-vitro antifungal activity of the fermentation quotient on bread spoilage moulds through growth/no-growth modelling and bread baking trials
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An integrated paediatric population PK/PD analysis of dDAVP : how do PK differences translate to clinical outcomes?
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Desmopressin oral lyophilisate in young children : new insights in pharmacokinetics and pharmacodynamics
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- Journal Article
- A1
- open access
Pediatric pharmacology of desmopressin in children with enuresis : a comprehensive review
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PKPD modeling and dosing considerations in advanced ovarian cancer patients treated with cisplatin-based intraoperative intraperitoneal chemotherapy
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PBPK and its virtual populations : the impact of physiology on pediatric pharmacokinetic predictions of tramadol
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A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers
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Growth/no-growth models of in-vitro growth of Penicillium paneum as a function of thyme essential oil, pH, a, temperature
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Model-based analysis of treatment effects of paclitaxel microspheres in a microscopic peritoneal carcinomatosis model in mice.
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SAFEPEDRUG : safer pediatric drugs for children: what have we learned?
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- Journal Article
- A1
- open access
Preclinical evaluation of local prolonged release of paclitaxel from gelatin microspheres for the prevention of recurrence of peritoneal carcinomatosis in advanced ovarian cancer
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Effect of packaging oxygen transmission rate on the shelf life of ready-to-heat foods susceptible to postcontamination during refrigerated and illuminated storage
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A physiologically based pharmacokinetic perspective on the clinical utility of albumin-based dose adjustments in critically ill patients
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The use of PBPK modeling across the pediatric age range using propofol as a case
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- Conference Paper
- C3
- open access
Assessment of the antifungal preservation potential of natural water or oil soluble compounds in both in-vitro and bread baking trials
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- Journal Article
- A1
- open access
A dried blood spot assay for paclitaxel and its metabolites
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Determination of plasma concentration reference ranges for oral aripiprazole, olanzapine, and quetiapine
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- Journal Article
- A1
- open access
Relationship between antipsychotic blood levels and treatment failure during the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study
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Solid fat influences sorbic acid partitioning and enhances the preservation effect on C. guilliermondii in biphasic food model systems
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Claiming desmopressin therapeutic equivalence in children requires pediatric data : a population PKPD analysis
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A model-based analysis of the kinetics of leukocytes in stage III ovarian cancer patients treated with neo-adjuvant chemotherapy, cytoreductive surgery and cisplatin-based intraperitoneal chemoperfusion
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Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population
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PK/PD studies in pigs leading to optimization of treatment dose in MNE?
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Results of a multicenter population pharmacokinetic study of ciprofloxacin in children with complicated urinary tract infection
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- Journal Article
- A1
- open access
A systems pharmacology model for inflammatory bowel disease
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- Conference Paper
- C3
- open access
Pediatric drug development: towards maturity : desmopressin as a case
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- Conference Paper
- C3
- open access
A novel approach in paediatric drug research : the development of a juvenile pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case 1
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- Journal Article
- A1
- open access
Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population
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- Journal Article
- A1
- open access
Inactivation of Salmonella, Listeria monocytogenes and Escherichia coli O157:H7 inoculated on coriander by freeze-drying and supercritical CO2 drying
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Influence of pH and structure on sorbic acid distribution and growth of C. guilliermondii in fat-based products
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PBPK in preterm and term neonates : a review
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- Conference Paper
- C3
- open access
Paediatric PBPK modelling of propofol using the middle out approach
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- Journal Article
- A1
- open access
Pharmacokinetic analysis of modified-release metoprolol formulations : an interspecies comparison
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Dosing and switching strategies for paliperidone palmitate 3-month formulation in patients with schizophrenia based on population pharmacokinetic modeling and simulation, and clinical trial data
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Population pharmacokinetics of a novel once-every 3 months intramuscular formulation of paliperidone palmitate in patients with schizophrenia
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Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound
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Modeling the relationship between exposure to abiraterone and prostate-specific antigen dynamics in patients with metastatic castration-resistant prostate cancer
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- Journal Article
- A1
- open access
In vivo contribution of deoxynivalenol-3-β-D-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics
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The influence of liquid oil, solid fat and pH on the inhibitory effect of potassium sorbate on Candida guilliermondii
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Population pharmacokinetic modeling of tapentadol extended release (ER) in healthy subjects and patients with moderate or severe chronic pain
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What about confidence intervals? : a word of caution when interpreting PTA simulations
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- Conference Paper
- C3
- open access
Bioequivalence in adults does not mean bioequivalence in children
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Population pharmacokinetic modeling of canagliflozin in healthy volunteers and patients with type 2 diabetes mellitus
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Bioequivalence in adults is not always bioequivalence in children
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Mycotoxin production and predictive modelling kinetics on the growth of Aspergillus flavus and Aspergillus parasiticus isolates in whole black peppercorns (Piper nigrum L)
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A model-based analysis of the predictive performance of different renal function markers for cefepime clearance in the ICU
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Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children
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PK/PD modelling of the QT interval : a step towards defining the translational relationship between in vitro, awake Beagle dogs, and humans
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- Journal Article
- A1
- open access
Effects of food and pharmaceutical formulation on desmopressin pharmacokinetics in children
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Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children
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Deoxynivalenol-3-β-D-glucoside : in vitro cytotoxicity and in vivo oral bioavailability and hydrolysis in broiler chicken and pig
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vRNA structured population model for Hepatitis C Virus dynamics
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Strategies to increase the stability of intermediate moisture foods towards Zygosaccharomyces rouxii: the effect of temperature, ethanol, pH and water activity, with or without the influence of organic acids
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Modelling of the growth/no growth interface of Wallemia sebi and Eurotium herbariorum as a function of pH, aW and ethanol concentration
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Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities
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Towards patient stratification in systemic lupus erythematosus using a systems pharmacology approach
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Building an inflammatory bowel disease network, a systems pharmacology approach
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Oral bioavailability, hydrolysis, and comparative toxicokinetics of 3-acetyldeoxynivalenol and 15-acetyldeoxynivalenol in broiler chickens and pigs
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Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates
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Practical guidance for dosing and switching from paliperidone palmitate 1 monthly to 3 monthly formulation in schizophrenia
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Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation
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- Journal Article
- A1
- open access
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data
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Correlation between prostate-specific antigen kinetics and overall survival in abiraterone acetate-treated castration-resistant prostate cancer patients
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Population pharmacokinetic model of ibrutinib, a Bruton tyrosine kinase inhibitor, in patients with B cell malignancies
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Population pharmacokinetic-pharmacodynamic (PKPD) modeling of ibrutinib in patients with B-cell malignancies
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Packaging of fish and fishery products
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Predictive modelling kinetics on the growth and mycotoxin production of Aspergillus flavus and Aspergillus parasiticus isolates in whole black peppercorns (Piper nigrum L.)
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Effect of muscle, ageing time and modified atmosphere packaging conditions on the colour, oxidative and microbiological stability of packed beef
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A model based analysis of IPEC dosing of paclitaxel in rats
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Population pharmacokinetic analysis of abiraterone in chemotherapy-Na < ve and docetaxel-treated patients with metastatic castration-resistant prostate cancer
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Dopamine D2 receptor occupancy as a predictor of catalepsy in rats: a pharmacokinetic-pharmacodynamic modeling approach
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Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery
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Predictions of in vivo prolactin levels from in vitro Ki values of D-2 receptor antagonists using an agonist-antagonist interaction model
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- Conference Paper
- C1
- open access
PredOxyPack®: how to predict the impact of the cold chain conditions on the oxygen barrier properties of packaging
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Population pharmacokinetics of JNJ-37822681, a selective fast-dissociating dopamine D-2-receptor antagonist, in healthy subjects and subjects with schizophrenia and dose selection based on simulated D-2-receptor occupancy
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Modelling and simulation of placebo effect: application to drug development in schizophrenia
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Understanding and attitude regarding the shelf life labels and dates on pre-packed food products by Belgian consumers
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Mixed-effects beta regression for modeling continuous bounded outcome scores using NONMEM when data are not on the boundaries
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Modeling continuous bounded outcome scores using beta regression with NONMEM (R) VII
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A quantitative microbiological exposure assessment model for Bacillus cereus in REPFEDs
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New research on modified atmosphere packaging and pathogen behaviour
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Development of a time-to-detect growth model for heat-treated Bacillus cereus spores
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Growth/no growth models for heat-treated psychrotrophic Bacillus cereus spores under cold storage
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Model based dosing rationale for darunavir when co-administered with low-dose ritonavir in pediatric HIV-1 infected patients
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- Conference Paper
- C1
- open access
Predictive models to support manufacturers of processed meat in their compliance with EU regulation 2073/2005
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Photocatalytic degradation of the antibiotic moxifloxacin: a deeper look at the degradation products and residual antibacterial activity
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Heterogeneous photocatalysis of moxifloxacin: identification of degradation products and determination of residual antibacterial activity
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Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia
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Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia, part I: the use of PANSS total score and clinical utility
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Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia, part II: the use of subscales of the PANSS score
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Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale
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Screening of different stress factors and development of growth/no growth models for Zygosaccharomyces rouxii in modified Sabouraud medium, mimicking intermediate moisture foods (IMF)
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Shrinkage in nonlinear mixed-effects population models: quantification, influencing factors, and impact
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Monitoring the intracellular pH of Zygosaccharomyces bailii by green fluorescent protein
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A predictive model for the growth/no growth boundary of Zygosaccharomyces bailii at 7°C and conditions mimicking acidified sauces
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Population pharmacokinetics and pharmacodynamics of rivaroxaban in patients with acute coronary syndromes
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- Journal Article
- A1
- open access
Pharmacokinetic-pharmacodynamic modeling of the D-2 and 5-HT2A receptor occupancy of risperidone and paliperidone in rats
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Balancing efficacy and safety in the clinical development of an atypical antipsychotic, paliperidone extended-release
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Modeling delayed drug effect using discrete-time nonlinear autoregressive models: a connection with indirect response models
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Non-linear mixed effect modeling of the time-variant disposition of erythropoietin in anemic cancer patients
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Critical evaluation of the EU-technical guidance on shelf-life studies for L. monocytogenes on RTE-foods: a case study for smoked salmon
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Growth/no-growth models for heat-treated spores of psychrotrophic Bacillus cereus strains
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A time scaling approach to develop an in vitro-in vivo correlation (IVIVC) model using a convolution-based technique
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Impact of low percentage of data below the quantification limit on parameter estimates of pharmacokinetic models
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The importance of expressing antimicrobial agents on water basis in growth/no growth interface models: a case study for Zygosaccharomyces bailii
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Structural models describing placebo treatment effects in schizophrenia and other neuropsychiatric disorders
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On the critical evaluation of growth/no growth assessment of Zygosaccharomyces bailii with optical density measurements: liquid versus structured media
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- Journal Article
- A1
- open access
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D-2 receptor occupancy of olanzapine in rats
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- Conference Paper
- C3
- open access
Exposure assessment of bisphenol A from food contact materials
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Modeling the effectiveness of paliperidone ER and olanzapine in schizophrenia: meta-analysis of 3 randomized, controlled clinical trials
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Population pharmacokinetics of oral risperidone in children, adolescents and adults with psychiatric disorders
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Modelling the growth/no growth boundary of Zygosaccharomyces bailii in acidic conditions: a contribution to the alternative method to preserve foods without using chemical preservatives
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Predicting the headspace oxygen level due to oxygen permeation across multilayer polymer packaging materials: a practical software simulation tool
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Dosing information for paliperidone palmitate - a once-monthly injectable atypical antipsychotic - based on population pharmacokinetic analysis
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What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it?
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Population pharmacokinetics of intramuscular paliperidone palmitate in patients with schizophrenia: a novel once-monthly, long-acting formulation of an atypical antipsychotic
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An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment
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A peculiar stimulatory effect of acetic and lactic acid on growth and fermentative metabolism of Zygosaccharomyces bailii
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D2-receptor occupancies and corresponding plasma concentrations: a comparison of paliperidone extended-release (ER) with risperidone immediate-release (IR)
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Bridging the gap between academia and industry: predictive microbiology for the food industry
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Expression of virulence genes of Listeria monocytogenes after growth on vacuum-packed cold-smoked salmon, stored at 7°C
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Expression of virulence genes of Listeria monocytogenes after growth on vacuum-packed cold-smoked salmon, stored at 7°C
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Influence of acid stress on survival, expression of virulence genes and invasion capacity into Caco-2 cells of Listeria monocytogenes strains of different origins
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Modelling the influence of the inoculation level on the growth/no growth interface of Listeria monocytogenes as a function of pH, a(w) and acetic acid
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The importance of growth/no growth models for specific organisms within the food industry
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Quantifying the effect of food structure on microbial spoilage characteristics by means of a semisolid food model system
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Modeling the growth/no growth interface of Zygosaccharomyces bailii in a viscoelastic food model system
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Prevalence and challenge tests of Listeria monocytogenes in Belgian produced and retailed mayonnaise-based deli-salads, cooked meat products and smoked fish between 2005 and 2007
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Design of an experimental viscoelastic food model system for studying Zygosaccharomyces bailii spoilage in acidic sauces
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- PhD Thesis
- open access
Microbial stability and safety of acid sauces and mayonnaise-based salads assessed through probabilistic growth/no growth models
(2008) -
Basic pharmacodynamic models for agents that alter the lifespan distribution of natural cells
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Modelling the growth/no growth boundary of spoilage micro-organisms in fods as an alternative method to preserve products without uging chemical preservatieves.
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Classification of RTE food according to the potential risk they represent for listeriosis based on data from end product testing and challenge testing
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A nonlinear mixed effects IVIVC model for multi-release drug delivery systems
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Gedrag en virulentie van Listeria monocytogenes in minimaal behandelde levensmiddelen
(2008) -
Modelling the growth/no growth boundary of spoilage micro-organisms in foods as an alternative method to preserve products without using chemical preservatives.
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Revisiting raw data processing procedures for the development of growth/no growth models
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Sensitivity of growth/no growth models with respect to raw data processing procedures
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Modelling the unexpected effect of acetic and lactic acid in combination with pH and a(w) on the growth/no growth interface of Zygosaccharomyces bailii
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Heat resistance of Bacillus cereus emetic toxin, cereulide
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Evaluation of the contamination of Listeria monocytogenes in 3 categories of ready-to-eat foods based on data from end product testing
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Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder
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Development and assessment of growth models incorporating the effect of cell density on the growth probability of listeria monocytogenes
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Evaluation of the microbial safety and stability of salads and sauces based on growth/no growth models for different microorganisms.
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Het gebruik van predictieve modellen voor L. monocytogenes in de levensmiddelenindustrie.
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The effect of micro-architectural structure of cabbage substratum and or background bacterial flora on the growth of Listeria monocytogenes
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Growth/no growth models describing the influence of pH, lactic and acetic acid on lactic acid bacteria developed to determine the stability of acidified sauces
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Development of a practical tool to predict the residual headspace oxygen level in packaged food products
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Simulation in clinical drug development
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Evaluation of growth/no growth modelling approaches on a non-abrupt growth/no growth interface of Listeria monocytogenes
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Exploring the performance of logistic regression model types on growth/no growth data of Listeria monocytogenes
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Influence of pH, water activity and acetic acid concentration on Listeria monocytogenes at 7 degrees C: Data collection for the development of a growth/no growth model
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Performance of a growth-No growth model for Listeria monocytogenes developed for mayonnaise-based salads: Influence of strain variability, food matrix, inoculation level, and presence of sorbic and benzoic acid
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Stimulation effect of lactic acid in the presence of acetic acid at low pH on the growth of the food spoilage yeast Zygosaccharomyces bailii
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A critical comparison of logistic regression model types applied on growth/ no growth data of Listeria monocytogenes as function of pH, water activity and acetic acid
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A pharmacokinetic model to document the interconversion between the enantiomers of paliperidone
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A pharmacokinetic model to document the interconversion between paliperidone's enantiomers
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A growth/no growth model for Listeria Monocytogenes validated in mayonnaise based salads.
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Microbial safety of mayonnaise based salads: a growth/no growth model for Listeria monocytogenes as a predictive tool
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Microbial safety of mayonnaise based salads: a growth/no growth model for Listeria monocytogenes as a predictive tool
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Pharmacokinetic profile of long-acting injectable risperidone at steady-state: comparison with oral administration
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Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin
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Risk assessment of Listeria monocytogenes in refrigerated acidified food products: data generation for development of a growth/no growth model
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Chitosan: antimicrobial activity, interactions with food components and applicability as a coating on fruit and vegetables
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Risperidone does not affect steady-state pharmacokinetics of divalproex sodium in patients with bipolar disorder
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Chitosan as a food preservative: possibilities and limitations.
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Applicability of chitosan as a food preservative
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Chitosan as a food preservative: possibilities and limitations
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The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patients
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Kinetics and safety of a novel risperidone depot formulation
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The effect of different calcium-antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes
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Influence of human recombinant interleukin-1ß on the enantioselective disposition of propranolol in rats
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Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat
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Stereoselective pharmacokinetics of atenolol in the rat: influence of aging and of renal failure
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Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat
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The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat
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Inhibition of the metabolism of propranolol by nicardipine in rats: an in vitro study
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Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate
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High-performance liquid chromatographic method for the simultaneous determination of R-(−)- and S-(+)-hexobarbital in rat plasma
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The enantiomeric distribution of propranolol is not influenced by its ß-blocking activity
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Enantioselective pharmacokinetics of propranolol in the rat: marked differences between rat and man
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The influence of aging on the stereoselective pharmacokinetics and the metabolism of metoprolol in the rat
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Stereoselectivity of plasma protein binding and its pharmacokinetic consequences
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Stereoselective pharmacokinetics of propranolol in the rat
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Effect of aging on the pharmacokinetics of atenolol, metoprolol and propranolol in the rat