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Population pharmacodynamic modeling using the sigmoid E-max model : influence of inter-individual variability on the steepness of the concentration-effect relationship : a simulation study
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- Journal Article
- A1
- open access
Estimation of ontogeny functions for renal transporters using a combined population pharmacokinetic and physiology-based pharmacokinetic approach : application to OAT1,3
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PKPD modeling and dosing considerations in advanced ovarian cancer patients treated with cisplatin-based intraoperative intraperitoneal chemotherapy
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PBPK and its virtual populations : the impact of physiology on pediatric pharmacokinetic predictions of tramadol
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PK/PD modelling of the QT interval : a step towards defining the translational relationship between in vitro, awake Beagle dogs, and humans
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Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation
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Predictions of in vivo prolactin levels from in vitro Ki values of D-2 receptor antagonists using an agonist-antagonist interaction model
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Shrinkage in nonlinear mixed-effects population models: quantification, influencing factors, and impact
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- Journal Article
- A1
- open access
Controlled crystallization of the lipophilic drug fenofibrate during freeze-drying: elucidation of the mechanism by in-line Raman spectroscopy
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Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate
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Determination of the mucosal irritation potential of oral piroxicam formulations on the gastric mucosa of dogs compared to the slug mucosal irritation test