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Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue
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Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity
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Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs
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Lipid-polyglutamate nanoparticle vaccine platform
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Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**
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- Journal Article
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Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators
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Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles
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- Journal Article
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Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy
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- Miscellaneous
- open access
Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine
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Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists
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Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates
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Hyaluronic acid conjugates of TLR7/8 agonists for targeted delivery to secondary lymphoid tissue
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Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses
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Dendritic cell targeting mRNA lipopolyplexes combine strong antitumor T-cell immunity with improved inflammatory safety
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Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide
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- Journal Article
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Topical imiquimod yields systemic effects due to unintended oral uptake
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Coadministration of a plasmid encoding HIV-1 Gag enhances the efficacy of cancer DNA vaccines
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pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation
(2016) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113(29). p.8098-8103 -
Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses
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Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity