Ghent University Academic Bibliography

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Your filters: cql: author exact F61853C2-F0ED-11E1-A9DE-61C894A0A6B4

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Rare sugar metabolism and impact on insulin sensitivity along the gut-liver-muscle axis in vitro

Amar Daniël Emanuel Van Laar (UGent) , Charlotte Grootaert (UGent) , Andreja Rajkovic (UGent) , Tom Desmet (UGent) , Koen Beerens (UGent) and John Van Camp (UGent)

(2023) NUTRIENTS. 15(7).
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Glycosidic linkage of rare and new-to-nature disaccharides reshapes gut microbiota in vitro

Stanley Omondi Onyango (UGent) , Koen Beerens (UGent) , Qiqiong Li (UGent) , John Van Camp (UGent) , Tom Desmet (UGent) and Tom Van de Wiele (UGent)

(2023) FOOD CHEMISTRY. 411.
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A colorimetric assay for the screening and kinetic analysis of nucleotide sugar 4,6-dehydratases

Ulrike Vogel (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2022) ANALYTICAL BIOCHEMISTRY. 655.
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Exploration of archaeal nucleotide sugar epimerases unveils a new and highly promiscuous GDP-Gal4E subgroup

Carlos Alvarez Quispe (UGent) , Matthieu Da Costa (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2022) CURRENT RESEARCH IN BIOTECHNOLOGY. 4. p.350-358
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Insertions and deletions in protein evolution and engineering

Simone Savino (UGent) , Tom Desmet (UGent) and Jorick Franceus (UGent)

(2022) BIOTECHNOLOGY ADVANCES. 60.
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Building mutational bridges between carbohydrate-active enzymes

Jorick Franceus (UGent) , Jolien Lormans (UGent) and Tom Desmet (UGent)

(2022) CURRENT OPINION IN BIOTECHNOLOGY. 78.
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In vitro stability and ex vivo absorption of thymol monoglucosides in the porcine gut

Noémie Van Noten, Elout Van Liefferinge (UGent) , Jeroen Degroote (UGent) , Stefaan De Smet (UGent) , Tom Desmet (UGent) and Joris Michiels (UGent)

(2022) ANIMAL. 16(1).
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Nucleotide sugar dehydratases : structure, mechanism, substrate specificity, and application potential

Ulrike Vogel (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2022) JOURNAL OF BIOLOGICAL CHEMISTRY. 298(4).
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Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

Silke Geurs (UGent) , Dorien Clarisse (UGent) , Freya Baele, Jorick Franceus (UGent) , Tom Desmet (UGent) , Karolien De Bosscher (UGent) and Matthias D'hooghe (UGent)

(2022) CHEMICAL COMMUNICATIONS. 58(42). p.6239-6242
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GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential

Koen Beerens (UGent) , Ophelia Gevaert and Tom Desmet (UGent)

(2022) FRONTIERS IN MOLECULAR BIOSCIENCES. 8.
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Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model

Amar Daniël Emanuel Van Laar (UGent) , Charlotte Grootaert (UGent) , Filip Van Nieuwerburgh (UGent) , Dieter Deforce (UGent) , Tom Desmet (UGent) , Koen Beerens (UGent) and John Van Camp (UGent)

(2022) NUTRIENTS. 14(3).
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Sweet biotechnology : enzymatic production and digestibility screening of novel kojibiose and nigerose analogues

Shari Dhaene (UGent) , Amar Daniël Emanuel Van Laar (UGent) , Marc De Doncker (UGent) , Emma De Beul (UGent) , Koen Beerens (UGent) , Charlotte Grootaert (UGent) , Jurgen Caroen (UGent) , Johan Van der Eycken (UGent) , John Van Camp (UGent) and Tom Desmet (UGent)

(2022) JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 70(11). p.3502-3511
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Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Jorick Franceus (UGent) , Jolien Lormans (UGent) , Lore Cools, Matthias D'hooghe (UGent) and Tom Desmet (UGent)

(2021) ACS CATALYSIS. 11(10). p.6225-6233
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Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol

Jorick Franceus (UGent) , Zorica Ubiparip (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) CHEMBIOCHEM. 22(18). p.2777-2782
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Defined synthesis of cellotriose by cellobiose phosphorylase mutant

Zorica Ubiparip (UGent) , David Sáez, Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) International Symposium on Biocatalysis and Biotransformations (Biotrans 2021), Abstracts.
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Engineering of cellobiose phosphorylase for the synthesis of prebiotic cellotriose

Zorica Ubiparip (UGent) , David Sáez Moreno, Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) International Conference on Renewable Resources & Biorefineries, 17th, Abstracts.
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Enzymatic synthesis of phloretin α‐glucosides using a sucrose phosphorylase mutant and its effect on solubility, antioxidant properties and skin absorption

Jose Luis González Alfonso, Zorica Ubiparip (UGent) , Elena Jimenez‐Ortega, Ana Poveda, Cristina Alonso, Luisa Coderch, Jesus Jimenez‐Barbero, Julia Sanz‐Aparicio, Antonio O. Ballesteros, Tom Desmet (UGent) , et al.

(2021) ADVANCED SYNTHESIS & CATALYSIS. 363(12). p.3079-3089
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β-Glucan phosphorylases in carbohydrate synthesis

Zorica Ubiparip (UGent) , Marc De Doncker (UGent) , Koen Beerens (UGent) , Jorick Franceus (UGent) and Tom Desmet (UGent)

(2021) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 105(10). p.4073-4087
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Exploration of GH94 sequence space for enzyme discovery reveals a novel glucosylgalactose phosphorylase specificity

Marc De Doncker (UGent) , Chloé De Graeve, Jorick Franceus (UGent) , Koen Beerens (UGent) , Vladimír Křen, Helena Pelantová, Ronny Vercauteren and Tom Desmet (UGent)

(2021) CHEMBIOCHEM. 22(23). p.3319-3325
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Towards sustainable production of defined oligosaccharides : enzymatic synthesis of high purity cellotriose

Zorica Ubiparip (UGent) , David Sáez Moreno, Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) EFIB 2021, Abstacts.
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Discovery of a novel GDP-glucose 4-epimerase in archaea reveals an uncommon promiscuity

Carlos Alvarez Quispe (UGent) , Matthieu Da Costa (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2021) ProtStab2021, 13th International Conference on Protein Stabilization, Abstracts.
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Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering

Matthieu Da Costa (UGent) , Ophelia Gevaert, Stevie Van Overtveldt, Joanna Lange, Henk-Jan Joosten, Tom Desmet (UGent) and Koen Beerens (UGent)

(2021) BIOTECHNOLOGY ADVANCES. 48.
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Stereo-electronic control of reaction selectivity in short-chain dehydrogenases : decarboxylation, epimerization, and dehydration

Annika J.E. Borg, Koen Beerens (UGent) , Martin Pfeiffer, Tom Desmet (UGent) and Bernd Nidetzky

(2021) CURRENT OPINION IN CHEMICAL BIOLOGY. 61. p.43-52
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Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion

Christian Rapp, Stevie Van Overtveldt, Koen Beerens (UGent) , Hansjörg Weber, Tom Desmet (UGent) and Bernd Nidetzky

(2021) APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 87(4).
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Kojibiose and trehalose long-term supplementation reveals significant metabolic differences and disaccharide dependent microbial community shift in a human gastrointestinal model

Stanley Omondi Onyango (UGent) , Koen Beerens (UGent) , Xinlin Jiao, Tom Desmet (UGent) and Tom Van de Wiele (UGent)

(2021) 9th Microbiome & Probiotics R&D and Business Collaboration Forum, Abstracts.
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Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65

Emma De Beul (UGent) , Alana Jongbloet, Jorick Franceus (UGent) and Tom Desmet (UGent)

(2021) MOLECULES. 26(20).
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Effects of thymol and thymol α-D-Glucopyranoside on intestinal function and microbiota of weaned pigs

Noémie Van Noten, Jeroen Degroote (UGent) , Elout Van Liefferinge (UGent) , Bernard Taminiau, Stefaan De Smet (UGent) , Tom Desmet (UGent) and Joris Michiels (UGent)

(2020) ANIMALS. 10(2).
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Synthesis, trehalase hydrolytic resistance and inhibition properties of 4-and 6-substituted trehalose derivatives

Shari Dhaene (UGent) , Johan Van der Eycken (UGent) , Koen Beerens (UGent) , Jorick Franceus (UGent) , Tom Desmet (UGent) and Jurgen Caroen (UGent)

(2020) JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 35(1). p.1964-1989
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Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases

Benoît Desguin, Julian Urdiain-Arraiza, Matthieu Da Costa (UGent) , Matthias Fellner, Jian Hu, Robert P. Hausinger, Tom Desmet (UGent) , Pascal Hols and Patrice Soumillion

(2020) SCIENTIFIC REPORTS. 10(1).
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Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity

Tim Van de Walle, Marina Briand, Ana Mitrović, Izidor Sosič, Stanislav Gobec, Janko Kos, Leentje Persoons, Dirk Daelemans, Steven De Jonghe, Zorica Ubiparip (UGent) , et al.

(2020) CHEMMEDCHEM. 15(24). p.2477-2490
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Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose

Zorica Ubiparip (UGent) , David Sáez Moreno, Koen Beerens (UGent) and Tom Desmet (UGent)

(2020) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 104(19). p.8327-8337
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Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13 : discovery, application and engineering

Jorick Franceus (UGent) and Tom Desmet (UGent)

(2020) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21(7).
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Weaning affects the glycosidase activity towards phenolic glycosides in the gut of piglets

Noémie Van Noten, Elout Van Liefferinge (UGent) , Jeroen Degroote (UGent) , Stefaan De Smet (UGent) , Tom Desmet (UGent) and Joris Michiels (UGent)

(2020) JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION. 104(5). p.1432-1443
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Fate of thymol and its monoglucosides in the gastrointestinal tract of piglets

Noémie Van Noten, Elout Van Liefferinge (UGent) , Jeroen Degroote (UGent) , Stefaan De Smet (UGent) , Tom Desmet (UGent) and Joris Michiels (UGent)

(2020) ACS OMEGA. 5(10). p.5241-5248
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Determinants of the nucleotide specificity in the carbohydrate epimerase family 1

Stevie Van Overtveldt, Matthieu Da Costa (UGent) , Ophelia Gevaert, Henk-Jan Joosten, Koen Beerens (UGent) and Tom Desmet (UGent)

(2020) BIOTECHNOLOGY JOURNAL. 15(11).
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GDP-altrose as novel product of GDP-mannose 3,5-epimerase : revisiting its reaction mechanism

Ophelia Gevaert, Stevie Van Overtveldt, Matthieu Da Costa (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2020) INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 165(part B). p.1862-1868
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Novel insights into the existence of the putative UDP-glucuronate 5-epimerase specificity

Ophelia Gevaert, Stevie Van Overtveldt, Matthieu Da Costa (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2020) CATALYSTS. 10(2).
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Fermentation of rare sugar kojibiose by the oral bacteria is slow yet bacteria specific

Stanley Omondi Onyango (UGent) , Nele De Clercq, Koen Beerens (UGent) , Tom Desmet (UGent) and Tom Van de Wiele (UGent)

(2020) NSABS 2020, 25th National Symposium for Applied Biological Sciences, Abstracts.
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Oral microbiota display profound differential metabolic kinetics and community shifts upon incubation with sucrose, trehalose, kojibiose, and xylitol

Stanley Omondi Onyango (UGent) , Nele De Clercq, Koen Beerens (UGent) , John Van Camp (UGent) , Tom Desmet (UGent) and Tom Van de Wiele (UGent)

(2020) APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 86(16).
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Effect of age on the functional glycosidase activity in the small intestinal mucosa of piglets

Noémie Van Noten, Elout Van Liefferinge (UGent) , Jeroen Degroote (UGent) , Tom Desmet (UGent) , Stefaan De Smet (UGent) and Joris Michiels (UGent)

(2019) Book of abstracts of the 70th Annual Meeting of the European Federation of Animal Science.
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Structural features on the substrate-binding surface of fungal lytic polysaccharide monooxygenases determine their oxidative regioselectivity

Barbara Danneels, Magali Tanghe (UGent) and Tom Desmet (UGent)

(2019) BIOTECHNOLOGY JOURNAL. 14(3).
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Rational design of an improved transglucosylase for production of the rare sugar nigerose

Jorick Franceus (UGent) , Shari Dhaene (UGent) , Hannes Decadt (UGent) , Judith Vandepitte, Jurgen Caroen (UGent) , Johan Van der Eycken (UGent) , Koen Beerens (UGent) and Tom Desmet (UGent)

(2019) CHEMICAL COMMUNICATIONS. 55(31). p.4531-4533
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CARBAFIN : developing a glycosylation platform technology to an industrial level

Zorica Ubiparip (UGent) , Christiane Luley, Tom Desmet (UGent) and Bernd Nidetzky

(2019) Renewable Resources and Biorefineries 15, Abstracts.
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Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves Depetter, Silke Geurs (UGent) , Jorick Franceus (UGent) , Damijan Knez, Tom Desmet (UGent) , Karolien De Bosscher (UGent) , Olivier De Wever (UGent) , Stanislav Gobec and Matthias D'hooghe (UGent)

(2019) CHEMISTRYSELECT. 4(42). p.12308-12312
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Discovery of novel cellodextrin phosphorylases : where bioinformatics meets biochemistry

Zorica Ubiparip (UGent) , Jorick Franceus (UGent) , Nídia Martins, Koen Beerens (UGent) and Tom Desmet (UGent)

(2019) European Summit of Industrial Biotechnology 2019, Abstracts.
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Structural comparison of a promiscuous and a highly specific sucrose 6F-phosphate phosphorylase

Jorick Franceus (UGent) , Nikolas Capra, Tom Desmet (UGent) and Andy-Mark W.H. Thunnissen

(2019) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(16).
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Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates

Atiruj Theppawong (UGent) , Tim Van de Walle, Charlotte Grootaert (UGent) , Kristof Van Hecke (UGent) , Nathalie Catry, Tom Desmet (UGent) , John Van Camp (UGent) and Matthias D'hooghe (UGent)

(2019) CHEMISTRYOPEN. 8(2). p.236-247
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Characterization of the first bacterial and thermostable GDP-mannose 3,5-epimerase

Ophelia Gevaert, Stevie Van Overtveldt, Koen Beerens (UGent) and Tom Desmet (UGent)

(2019) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(14).
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Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines

Atiruj Theppawong (UGent) , Tim Van de Walle, Charlotte Grootaert (UGent) , Margot Bultinck, Tom Desmet (UGent) , John Van Camp (UGent) and Matthias D'hooghe (UGent)

(2018) CHEMISTRYOPEN. 7(5). p.381-392
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Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase

Jorick Franceus (UGent) , Lena Decuyper, Matthias D'hooghe (UGent) and Tom Desmet (UGent)

(2018) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 102(7). p.3183-3191
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Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Yves Depetter, Silke Geurs (UGent) , Flore Vanden Bussche, Rob De Vreese (UGent) , Jorick Franceus (UGent) , Tom Desmet (UGent) , Olivier De Wever (UGent) and Matthias D'hooghe (UGent)

(2018) MEDCHEMCOMM. 9(6). p.1011-1016
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Thermostable alpha-glucan phosphorylases : characteristics and industrial applications

Zorica Ubiparip (UGent) , Koen Beerens (UGent) , Jorick Franceus (UGent) , Ronny Vercauteren and Tom Desmet (UGent)

(2018) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 102(19). p.8187-8202
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Converting galactose into the rare sugar talose with cellobiose 2-epimerase as biocatalyst

Stevie Van Overtveldt, Ophelia Gevaert, Martijn Cherlet, Koen Beerens (UGent) and Tom Desmet (UGent)

(2018) MOLECULES. 23(10).
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Analysis of the substrate specificity of α-L-arabinofuranosidases by DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis

Maria João de Carvalho Maurício da Fonseca (UGent) , Edita Jurak, Kim Kataja, Emma R Master, Jean-Guy Berrin, Ingeborg Stals (UGent) , Tom Desmet (UGent) , Anita Van Landschoot (UGent) and Yves Briers (UGent)

(2018) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 102(23). p.10091-10102
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Kinetics of thymol and its glucosides along the gastro-intestinal tract of weaned piglets

Noémie Van Noten, Elout Van Liefferinge (UGent) , Joris Michiels (UGent) , Tom Desmet (UGent) and Stefaan De Smet (UGent)

(2018) ADVANCES IN ANIMAL BIOSCIENCES. 9(suppl. 2).
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Glycosylation of thymol to alter its kinetics along the gastro-intestinal tract of the piglet

Noémie Van Noten, Elout Van Liefferinge (UGent) , Joris Michiels (UGent) , Tom Desmet (UGent) and Stefaan De Smet (UGent)

(2018) ANR Forum, 43rd, Abstracts.
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Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams

Lena Decuyper, Jorick Franceus (UGent) , Shari Dhaene (UGent) , Maarten Debruyne (UGent) , Kevin Vandoorne, Nicola Piens, Griet Dewitte, Tom Desmet (UGent) and Matthias D'hooghe (UGent)

(2018) ACS OMEGA. 3(11). p.15235-15245
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CARBAFIN : developing a glycosylation platform technology to an industrial level

Zorica Ubiparip (UGent) , Christiane Luley, Tom Desmet (UGent) and Bernd Nidetzky

(2018) 29th Joint Glycobiology meeting 2018, Abstracts.
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Disulfide bridges as essential elements for the thermostability of lytic polysaccharide monooxygenase LPMO10C from Streptomyces coelicolor

Magali Tanghe (UGent) , Barbara Danneels (UGent) , Matthias Last, Koen Beerens (UGent) , Ingeborg Stals (UGent) and Tom Desmet (UGent)

(2017) PROTEIN ENGINEERING DESIGN & SELECTION. 30(5). p.401-408
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The 'epimerring' highlights the potential of carbohydrate epimerases for rare sugar production

Koen Beerens (UGent) , Stevie Van Overtveldt and Tom Desmet (UGent)

(2017) BIOCATALYSIS AND BIOTRANSFORMATION. 35(3). p.230-237
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Sequence determinants of nucleotide binding in Sucrose Synthase : improving the affinity of a bacterial Sucrose Synthase for UDP by introducing plant residues

Margo Diricks (UGent) , Alexander Gutmann, Simon Debacker, Griet Dewitte (UGent) , Bernd Nidetzky and Tom Desmet (UGent)

(2017) PROTEIN ENGINEERING DESIGN & SELECTION. 30(3). p.143-150
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Glycosyltransferase cascades for natural product glycosylation : use of plant instead of bacterial sucrose synthases improves the UDP-glucose recycling from sucrose and UDP

Alexander Gutmann, Alexander Lepak, Margo Diricks (UGent) , Tom Desmet (UGent) and Bernd Nidetzky

(2017) BIOTECHNOLOGY JOURNAL. 12(7).
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Biocatalytic synthesis of the rare sugar kojibiose : process scale-up and application testing

Koen Beerens (UGent) , Karel De Winter (UGent) , Davy Van de Walle (UGent) , Charlotte Grootaert (UGent) , Senem Kamiloglu (UGent) , Lisa Miclotte (UGent) , Tom Van de Wiele (UGent) , John Van Camp (UGent) , Koen Dewettinck (UGent) and Tom Desmet (UGent)

(2017) JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 65(29). p.6030-6041
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Glucosylglycerate phosphorylase, an enzyme with novel specificity involved in compatible solute metabolism

Jorick Franceus (UGent) , Denise Pinel (UGent) and Tom Desmet (UGent)

(2017) APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 83(19).
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CorNet : assigning function to networks of co-evolving residues by automated literature mining

Tom van den Bergh, Giorgio Tamo, Alberto Nobili, Yifeng Tao, Tianwei Tan, Uwe T Bornscheuer, Remko KP Kuipers, Bas Vroling, René M de Jong, Kalyanasundaram Subramanian, et al.

(2017) PLOS ONE. 12(5).
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Microbial enzymes for glycoside synthesis : development of sucrose phosphorylase as a test case

Tom Verhaeghe (UGent) , Karel De Winter (UGent) and Tom Desmet (UGent)

(2017) Biotechnology of microbial enzymes : production, biocatalysis and industrial applications. p.405-431
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High-throughput customized production of arabinoxylan-oligosaccharides (AXOS)

Maria João de Carvalho Maurício da Fonseca (UGent) , Ingeborg Stals (UGent) , Tom Desmet (UGent) , Anita Van Landschoot (UGent) and Yves Briers (UGent)

(2017) Industrial Biotechnology, 4th European summer school, Abstracts.
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A quantitative indicator diagram for lytic polysaccharide monooxygenases reveals the role of aromatic surface residues in HjLPMO9A regioselectivity

Barbara Danneels (UGent) , Magali Tanghe (UGent) , Henk-Jan Joosten, Thomas Gundinger, Oliver Spadiut, Ingeborg Stals (UGent) and Tom Desmet (UGent)

(2017) PLOS ONE. 12(5).
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Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold

Rob De Vreese (UGent) , Lisa Galle, Yves Depetter, Jorick Franceus (UGent) , Tom Desmet (UGent) , Kristof Van Hecke (UGent) , Veronick Benoy, Ludo Van Den Bosch and Matthias D'hooghe (UGent)

(2017) CHEMISTRY-A EUROPEAN JOURNAL. 23(1). p.128-136
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Correlated positions in protein evolution and engineering

Jorick Franceus (UGent) , Tom Verhaeghe (UGent) and Tom Desmet (UGent)

(2017) JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY. 44(4-5). p.687-695
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Using DSA-FACE to reveal the substrate specificity of α-L-arabinofuranosidases

Maria João de Carvalho Maurício da Fonseca (UGent) , Tom Desmet (UGent) , Anita Van Landschoot (UGent) , Ingeborg Stals (UGent) and Yves Briers (UGent)

(2016) Renewable Resources and Biorefineries 12, Abstracts. p.107-108
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Collision cross section prediction of deprotonated phenolics in a travelling-wave ion mobility spectrometer using molecular descriptors and chemometrics

Bryan Gonzales (UGent) , Guy Smagghe (UGent) , Sofie Coelus (UGent) , Dieter Adriaenssens (UGent) , Karel De Winter (UGent) , Tom Desmet (UGent) , Katleen Raes (UGent) and John Van Camp (UGent)

(2016) ANALYTICA CHIMICA ACTA. 924. p.68-76
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Biocatalytic production of novel glycolipids

Karel De Winter (UGent) , Griet Dewitte (UGent) , Hai Giang Tran and Tom Desmet (UGent)

(2016) Practical methods for biocatalysis and biotransformations 3. p.118-124
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Sucrose synthase : a unique glycosyltransferase for biocatalytic glycosylation process development

Katharina Schmölzer, Alexander Gutmann, Margo Diricks (UGent) , Tom Desmet (UGent) and Bernd Nidetzky

(2016) BIOTECHNOLOGY ADVANCES. 34(2). p.88-111
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Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Nicola Piens, Sven De Craene, Jorick Franceus (UGent) , Karen Mollet (UGent) , Kristof Van Hecke (UGent) , Tom Desmet (UGent) and Matthias D'hooghe (UGent)

(2016) ORGANIC & BIOMOLECULAR CHEMISTRY. 14(47). p.11279-11288
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A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Lena Decuyper, Nicola Piens, Jens Mincke (UGent) , Jeroen Bomon (UGent) , Bert De Schrijver, Karen Mollet (UGent) , Karel De Winter (UGent) , Tom Desmet (UGent) and Matthias D'hooghe (UGent)

(2016) RSC ADVANCES. 6(59). p.54573-54579
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Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity

Tom Verhaeghe (UGent) , Karel De Winter (UGent) , Magali Berland, Rob De Vreese (UGent) , Matthias D'hooghe (UGent) , Bernard Offmann and Tom Desmet (UGent)

(2016) CHEMICAL COMMUNICATIONS. 52(18). p.3687-3689
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Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

Rob De Vreese (UGent) , Yves Depetter, Tom Verhaeghe (UGent) , Tom Desmet (UGent) , Veronick Benoy, Wanda Haeck, Ludo Van Den Bosch and Matthias D'hooghe (UGent)

(2016) ORGANIC & BIOMOLECULAR CHEMISTRY. 14(8). p.2537-2549
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Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-β-lactams

Hang Dao Thi (UGent) , Barbara Danneels (UGent) , Tom Desmet (UGent) , Kristof Van Hecke (UGent) , Tuyen Van Nguyen and Matthias D'hooghe (UGent)

(2016) ASIAN JOURNAL OF ORGANIC CHEMISTRY. 5(12). p.1480-1491
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Screening of recombinant glycosyltransferases reveals the broad acceptor specificity of stevia UGT-76G1

Griet Dewitte (UGent) , Maarten Walmagh (UGent) , Margo Diricks (UGent) , Alexander Lepak, Alexander Gutmann, Bernd Nidetzky and Tom Desmet (UGent)

(2016) JOURNAL OF BIOTECHNOLOGY. 233. p.49-55
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Stability analysis of a plant glycosyltransferase

Griet Dewitte (UGent) , Koen Beerens (UGent) , Margo Diricks (UGent) and Tom Desmet (UGent)

(2016) Protein Stabilisation, 11th International conference, Abstracts. p.46-46
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Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams

Nicola Piens, Lena Decuyper, Saskia Vander Meeren, Jens Mincke (UGent) , Jeroen Bomon (UGent) , Bert De Schrijver, Karen Mollet (UGent) , Karel De Winter (UGent) , Tom Desmet (UGent) and Matthias D'hooghe (UGent)

(2016) Book of abstracts : 4th annual G2C2 workshop and symposium.
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Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones

Lena Decuyper, Nicola Piens, Saskia Vander Meeren, Jens Mincke (UGent) , Jeroen Bomon (UGent) , Bert De Schrijver, Karen Mollet (UGent) , Karel De Winter (UGent) , Tom Desmet (UGent) and Matthias D'hooghe (UGent)

(2016) Chemical Research in Flanders, Symposium abstracts.
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Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity

Stephanie Vandekerckhove (UGent) , Sofie Van Herreweghe, Jasmine Willems, Barbara Danneels (UGent) , Tom Desmet (UGent) , Carmen de Kock, Peter J Smith, Kelly Chibale and Matthias D'hooghe (UGent)

(2015) EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 92. p.91-102
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Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Karen Mollet (UGent) , Lena Decuyper, Saskia Vander Meeren, Nicola Piens, Karel De Winter (UGent) , Tom Desmet (UGent) and Matthias D'hooghe (UGent)

(2015) ORGANIC & BIOMOLECULAR CHEMISTRY. 13(9). p.2716-2725
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Creating space for large acceptors: rational biocatalyst design for resveratrol glycosylation in an aqueous system

Mareike Dirks-Hofmeister (UGent) , Tom Verhaeghe (UGent) , Karel De Winter (UGent) and Tom Desmet (UGent)

(2015) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 54(32). p.9289-9292
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Enzymatic glycosylation of phenolic antioxidants: phosphorylase-mediated synthesis and characterization

Karel De Winter (UGent) , Griet Dewitte (UGent) , Mareike Dirks-Hofmeister (UGent) , Sylvie De Laet, Helena Pelantova, Vladimír Kren and Tom Desmet (UGent)

(2015) JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 63(46). p.10131-10139
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Capillary electrophoresis for the functional annotation of carbohydrate-active enzymes: two preliminary case studies

Maria João de Carvalho Maurício da Fonseca (UGent) , Tom Desmet (UGent) , Anita Van Landschoot (UGent) and Ingeborg Stals (UGent)

(2015) Applied Biological Sciences, 20th National symposium, Abstracts. p.12-12
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Recombinant expression of Trichoderma reesei Cel61A in Pichia pastoris: optimizing yield and N-terminal processing

Magali Tanghe (UGent) , Barbara Danneels (UGent) , Andrea Camattari, Anton Glieder, Isabel Vandenberghe (UGent) , Bart Devreese (UGent) , Ingeborg Stals (UGent) and Tom Desmet (UGent)

(2015) MOLECULAR BIOTECHNOLOGY. 57(11-12). p.1010-1017
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Chemoenzymatic synthesis of β-D-glucosides using cellobiose phosphorylase from Clostridium thermocellum

Karel De Winter (UGent) , Lisa Van Renterghem, Kathleen Wuyts, Helena Pelantová, Vladimír Křen, Wim Soetaert (UGent) and Tom Desmet (UGent)

(2015) ADVANCED SYNTHESIS & CATALYSIS. 357(8). p.1961-1969
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Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones

Anka Pejović, Barbara Danneels (UGent) , Tom Desmet (UGent) , Ba Thi Cham, Tuyen Van Nguyen, Niko S Radulović, Rastko D Vukicević and Matthias D'hooghe (UGent)

(2015) SYNLETT. 26(9). p.1195-2000
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Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

Rob De Vreese (UGent) , Nicholas Van Steen, Tom Verhaeghe, Tom Desmet (UGent) , Nadia Bougarne, Karolien De Bosscher (UGent) , Veronick Benoy, Wanda Haeck, Ludo Van Den Bosch and Matthias D'hooghe (UGent)

(2015) CHEMICAL COMMUNICATIONS. 51(48). p.9868-9871
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A structural classification of carbohydrate epimerases : from mechanistic insights to practical applications

Stevie Van Overtveldt, Tom Verhaeghe, Henk-Jan Joosten, Tom van den Bergh, Koen Beerens (UGent) and Tom Desmet (UGent)

(2015) BIOTECHNOLOGY ADVANCES. 33(8). p.1814-1828
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Identification of sucrose synthase in nonphotosynthetic bacteria and characterization of the recombinant enzymes

Margo Diricks (UGent) , Frederik De Bruyn (UGent) , Paul Van Daele, Maarten Walmagh (UGent) and Tom Desmet (UGent)

(2015) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 99(20). p.8465-8474
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UDP-hexose 4-epimerases: a view on structure, mechanism and substrate specificity

Koen Beerens (UGent) , Wim Soetaert (UGent) and Tom Desmet (UGent)

(2015) CARBOHYDRATE RESEARCH. 414. p.8-14
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Trehalose analogues: latest insights in properties and biocatalytic production

Maarten Walmagh (UGent) , Renfei Zhao (UGent) and Tom Desmet (UGent)

(2015) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 16(6). p.13729-13745
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Enhanced biomass degradation by polysaccharide monooxygenases

Magali Tanghe (UGent) , Barbara Danneels (UGent) , Ingeborg Stals (UGent) and Tom Desmet (UGent)

(2014) Renewable resources for biorefineries. In RSC Green Chemistry 27. p.64-78
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Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Lena Decuyper, Karen Mollet (UGent) , Saskia Vander Meeren, Nicola Piens, Karel De Winter (UGent) , Tom Desmet (UGent) and Matthias D'hooghe (UGent)

(2014) Book of abstracts : 18th Sigma-Aldrich organic synthesis meeting.
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Engineering the carbohydrate-binding site of Epa1p from Candida glabrata: generation of adhesin mutants with different carbohydrate specificity

Francesco S Ielasi, Tom Verhaeghe (UGent) , Tom Desmet (UGent) and Ronnie G Willaert

(2014) GLYCOBIOLOGY. 24(12). p.1312-1322
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The quest for a thermostable sucrose phosphorylase reveals sucrose 6'-phosphate phosphorylase as a novel specificity

Tom Verhaeghe (UGent) , Dirk Aerts (UGent) , Margo Diricks (UGent) , Wim Soetaert (UGent) and Tom Desmet (UGent)

(2014) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 98(16). p.7027-7037

Rare sugar metabolism and impact on insulin sensitivity along the gut-liver-muscle axis in vitro

Glycosidic linkage of rare and new-to-nature disaccharides reshapes gut microbiota in vitro

A colorimetric assay for the screening and kinetic analysis of nucleotide sugar 4,6-dehydratases

Exploration of archaeal nucleotide sugar epimerases unveils a new and highly promiscuous GDP-Gal4E subgroup

Insertions and deletions in protein evolution and engineering

Building mutational bridges between carbohydrate-active enzymes

In vitro stability and ex vivo absorption of thymol monoglucosides in the porcine gut

Nucleotide sugar dehydratases : structure, mechanism, substrate specificity, and application potential

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential

Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model

Sweet biotechnology : enzymatic production and digestibility screening of novel kojibiose and nigerose analogues

Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol

Defined synthesis of cellotriose by cellobiose phosphorylase mutant

Engineering of cellobiose phosphorylase for the synthesis of prebiotic cellotriose

Enzymatic synthesis of phloretin α‐glucosides using a sucrose phosphorylase mutant and its effect on solubility, antioxidant properties and skin absorption

β-Glucan phosphorylases in carbohydrate synthesis

Exploration of GH94 sequence space for enzyme discovery reveals a novel glucosylgalactose phosphorylase specificity

Towards sustainable production of defined oligosaccharides : enzymatic synthesis of high purity cellotriose

Discovery of a novel GDP-glucose 4-epimerase in archaea reveals an uncommon promiscuity

Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering

Stereo-electronic control of reaction selectivity in short-chain dehydrogenases : decarboxylation, epimerization, and dehydration

Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion

Kojibiose and trehalose long-term supplementation reveals significant metabolic differences and disaccharide dependent microbial community shift in a human gastrointestinal model

Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65

Effects of thymol and thymol α-D-Glucopyranoside on intestinal function and microbiota of weaned pigs

Synthesis, trehalase hydrolytic resistance and inhibition properties of 4-and 6-substituted trehalose derivatives

Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases

Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity

Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose

Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13 : discovery, application and engineering

Weaning affects the glycosidase activity towards phenolic glycosides in the gut of piglets

Fate of thymol and its monoglucosides in the gastrointestinal tract of piglets

Determinants of the nucleotide specificity in the carbohydrate epimerase family 1

GDP-altrose as novel product of GDP-mannose 3,5-epimerase : revisiting its reaction mechanism

Novel insights into the existence of the putative UDP-glucuronate 5-epimerase specificity

Fermentation of rare sugar kojibiose by the oral bacteria is slow yet bacteria specific

Oral microbiota display profound differential metabolic kinetics and community shifts upon incubation with sucrose, trehalose, kojibiose, and xylitol

Effect of age on the functional glycosidase activity in the small intestinal mucosa of piglets

Structural features on the substrate-binding surface of fungal lytic polysaccharide monooxygenases determine their oxidative regioselectivity

Rational design of an improved transglucosylase for production of the rare sugar nigerose

CARBAFIN : developing a glycosylation platform technology to an industrial level

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Discovery of novel cellodextrin phosphorylases : where bioinformatics meets biochemistry

Structural comparison of a promiscuous and a highly specific sucrose 6F-phosphate phosphorylase

Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates

Characterization of the first bacterial and thermostable GDP-mannose 3,5-epimerase

Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines

Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Thermostable alpha-glucan phosphorylases : characteristics and industrial applications

Converting galactose into the rare sugar talose with cellobiose 2-epimerase as biocatalyst

Analysis of the substrate specificity of α-L-arabinofuranosidases by DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis

Kinetics of thymol and its glucosides along the gastro-intestinal tract of weaned piglets

Glycosylation of thymol to alter its kinetics along the gastro-intestinal tract of the piglet

Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams

CARBAFIN : developing a glycosylation platform technology to an industrial level

Disulfide bridges as essential elements for the thermostability of lytic polysaccharide monooxygenase LPMO10C from Streptomyces coelicolor

The 'epimerring' highlights the potential of carbohydrate epimerases for rare sugar production

Sequence determinants of nucleotide binding in Sucrose Synthase : improving the affinity of a bacterial Sucrose Synthase for UDP by introducing plant residues

Glycosyltransferase cascades for natural product glycosylation : use of plant instead of bacterial sucrose synthases improves the UDP-glucose recycling from sucrose and UDP

Biocatalytic synthesis of the rare sugar kojibiose : process scale-up and application testing

Glucosylglycerate phosphorylase, an enzyme with novel specificity involved in compatible solute metabolism

CorNet : assigning function to networks of co-evolving residues by automated literature mining

Microbial enzymes for glycoside synthesis : development of sucrose phosphorylase as a test case

High-throughput customized production of arabinoxylan-oligosaccharides (AXOS)

A quantitative indicator diagram for lytic polysaccharide monooxygenases reveals the role of aromatic surface residues in HjLPMO9A regioselectivity

Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold

Correlated positions in protein evolution and engineering

Using DSA-FACE to reveal the substrate specificity of α-L-arabinofuranosidases

Collision cross section prediction of deprotonated phenolics in a travelling-wave ion mobility spectrometer using molecular descriptors and chemometrics

Biocatalytic production of novel glycolipids

Sucrose synthase : a unique glycosyltransferase for biocatalytic glycosylation process development

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity

Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-β-lactams

Screening of recombinant glycosyltransferases reveals the broad acceptor specificity of stevia UGT-76G1