Ghent University Academic Bibliography

Journal Article
A1
open access

Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis

Kevin De Muynck (UGent) , Lander Heyerick (UGent) , Federico Francesco De Ponti (UGent) , Bart Vanderborght (UGent) , Tim Meese (UGent) , Sanne Van Campenhout, Leen Baudonck, Eva Gijbels (UGent) , Pedro M. Rodrigues, Jesus M. Banales, et al.

(2024) HEPATOLOGY. 79(2). p.269-288

Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes

Studying macrophages in the murine steatotic liver using flow cytometry and confocal microscopy

A20 is a master switch of IL-33 signalling in macrophages and determines IL-33-induced lung immunity

Limitations of PLX3397 as a microglial investigational tool : peripheral and off-target effects dictate the response to inflammation

Kupffer cells contested as early drivers in the pathogenesis of primary sclerosing cholangitis

Transient Kupffer cell depletion and subsequent replacement by infiltrating monocyte-derived cells does not alter the induction or progression of hepatocellular carcinoma

Complementarity of single-nucleus and single-cell RNA sequencing to study the transcriptional heterogeneity of neuroblastoma tumors

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment

Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Liver macrophages in health and disease

A breath of fresh macrophages ameliorates inflammation in the hypoxic lung

Complementarity of single-nucleus and single-cell RNA sequencing to study the transcriptional heterogeneity of neuroblastoma tumors

Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues

Hepatic macrophage responses in inflammation, a function of plasticity, heterogeneity or both?

Welcoming c-MAF to the macrophage transcription factor VAM-ily

In matters of the heart, (cellular) communication is key

ILC3s control splenic cDC homeostasis via lymphotoxin signaling

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

The conventional dendritic cell lineage is born

ImmGen at 15

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Macrophage subsets in obesity, aligning the liver and adipose tissue

Transcriptional regulation of DC fate specification

Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection

Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver

Deep learning of immune cell differentiation

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche

ZEBs : novel players in immune cell development and function

Priority lane to cDC1 open for IRF8⁺ progenitors

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

The role of Kupffer cells in hepatic iron and lipid metabolism

Tissue unit-ed : lung cells team up to drive alveolar macrophage development

Myocarditis elicits dendritic cell and monocyte infiltration in the heart and self-antigen presentation by conventional type 2 dendritic cells

Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

'NOTCHing up' the in vitro production of dendritic cells

Macrophages and lipid metabolism

Does niche competition determine the origin of tissue-resident macrophages?

Barrier-tissue macrophages : functional adaptation to environmental challenges

Kupffer cell pool is maintained by local proliferation and the differentiation of bone marrow monocytes into short-lived monocyte-derived Kupffer cells during non-alcoholic steatohepatitis and recovery

Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool

TGFβR signalling controls CD103⁺CD11b⁺ dendritic cell development in the intestine

Myocardial infarction primes autoreactive T cells through activation of dendritic cells

Development of conventional dendritic cells : from common bone marrow progenitors to multiple subsets in peripheral tissues

Isolation and identification of intestinal myeloid cells

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

Conventional dendritic cells : identification, subsets, development, and functions

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species

IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively

Isolation and identification of conventional dendritic cell subsets from the intestine of mice and men

Lymph-borne CD8 alpha(+) dendritic cells are uniquely able to cross-prime CD8(+) T cells with antigen acquired from intestinal epithelial cells

CCR2⁺CD103⁻ intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells

Type 2 Innate Lymphoid Cells Drive CD4(+) Th2 Cell Responses

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103⁺CD11b⁺ DCs in the intestinal lamina propria

Mononuclear phagocytes of the intestine, the skin, and the lung

Dendritic cell subsets in the intestinal lamina propria : ontogeny and function

Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6C(hi) monocyte precursors

Intestinal CD103(+) dendritic cells : master regulators of tolerance?