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Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis
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Multi-omics profiling, in vitro and in vivo enhancer assays dissect the cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy
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Identifying and characterizing EZH2 as a druggable dependency factor for desmoid tumors in a genetic Xenopus tropicalis model for Gardner's Syndrome
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- Journal Article
- A1
- open access
Multi-omics approach dissects cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy
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- Journal Article
- A1
- open access
Engraftment of allotransplanted tumor cells in adult rag2 mutant Xenopus tropicalis
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CRISPR-SID : identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping
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- Journal Article
- A1
- open access
Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos
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RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis
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- Journal Article
- A1
- open access
ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia
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Homozygous null TBX4 mutations lead to posterior amelia with pelvic and pulmonary hypoplasia
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Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis
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Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis
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- Journal Article
- A1
- open access
Xenopus tropicalis : joining the armada in the fight against blood cancer
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- Journal Article
- A1
- open access
A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus
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RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
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CRISPR/Cas9 disease models in zebrafish and Xenopus : the genetic renaissance of fish and frogs
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CRISPR/Cas9 mediated knockout of rcbtb1 in Xenopus tropicalis to model RCBTB1-associated retinal disease
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CRISPR/Cas9 mediated knockout of rcbtb1 in Xenopus tropicalis to model RCBTB1-associated retinal disease
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- Journal Article
- A1
- open access
An atlas of Wnt activity during embryogenesis in Xenopus tropicalis
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Genotyping of CRISPR/Cas9 genome edited Xenopus tropicalis
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CRISPR/Cas9-mediated knockout of Rb1 in Xenopus tropicalis
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Cell cycle analysis of the embryonic brain of fluorescent reporter Xenopus tropicalis by flow cytometry
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Cancer models in Xenopus tropicalis by CRISPR/Cas9 mediated knockout of tumor suppressors
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Methods for CRISPR/Cas9 Xenopus tropicalis tissue-specific multiplex genome engineering
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Targeted genome engineering in Xenopus using the transcription activator-like effector nuclease (TALEN) technology
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- Conference Paper
- C3
- open access
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis
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How Wnt signaling builds the brain : bridging development and disease
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TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevant Xenopus tropicalis tumor models
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- Journal Article
- A1
- open access
Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4
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Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation
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Hearing loss in Waardenburg syndrome: a systematic review
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Studying the functionality of the homologous repair pathway in zebrafish embryos : heading for an in vivo functional test to evaluate the pathogenicity of BRCA2 variants
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- Journal Article
- A1
- open access
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis
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A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes
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Genetic defects in TAPT1 disrupt ciliogenesis and cause a complex lethal osteochondrodysplasia
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A molecular atlas of Xenopus respiratory system development
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SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein
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SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein
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TALEN mediated mutation of apc and β-catenin in Xenopus tropicalis as powerful models for Wnt driven cancer and Familial Adenomatous Polyposis (FAP)
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SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein
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- Journal Article
- A2
- open access
TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis
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SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein
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Defects in TAPT1, involved in axial skeletal patterning, cause a complex lethal recessive disorder of skeletal development
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- Journal Article
- A1
- open access
Fezf2 promotes neuronal differentiation through localised activation of Wnt/β-catenin signalling during forebrain development
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Design and use of transgenic reporter strains for detecting activity of signaling pathways in Xenopus
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- Journal Article
- A1
- open access
The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation
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- Journal Article
- A1
- open access
Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues
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Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis
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Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation
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The role of Wnt in cell signaling and cell adhesion during early vertebrate development
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You'd better catch that Wnt-primitive hematopoiesis requires canonical Wnt signaling
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Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling
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ARVCF Depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus
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Wnt/β-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo
(2010) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(37). p.16160-16165 -
Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development
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Direct control of Hoxd1 and Irx3 expression by Wnt/β-catenin signaling during anteroposterior patterning of the neural axis in Xenopus
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The chronic toxicity of molybdate to freshwater organisms, I: generating reliable effects data
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Requirement of Wnt/beta-catenin signaling in pronephric kidney development
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Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling
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Inhibition of the canonical Wnt signaling pathway during craniofacial development: impact on the craniofacial phenotype of Xenopus tadpoles
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Craniofacial phenotype of transgenic Xenopus tadpoles, after inhibition of the Wnt-signaling pathway during craniofacial development
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Craniofacial phenotype of transgenic Xenopus tadpoles, after inhibition of the Wnt-signaling pathway during craniofacial development
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Transgenic reporter tools tracing endogenous canonical wnt signaling in Xenopus
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Cell migration during development
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Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos
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Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes
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Mycobacterium liflandii infection in European colony of Silurana tropicalis
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Overlevingspensioen en/of arbeid: noden en behoeften van weduwen
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In vivo tracing of canonical Wnt signaling in Xenopus tadpoles by means of an inducible transgenic reporter tool
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A new generation of JASPAR, the open-access repository for transcription factor binding site profiles
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Canonical Wnt signaling is required for pronephric kidney tubule development.
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Kaiso/p120-catenin and TCF/Beta-Catenin complexes coordinately regulate canonical wnt gene targets.
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A genetic Xenopus laevis tadpole model to study lymphangiogenesis
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Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets
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Global inhibition of Lef1/Tcf-dependent Wnt signaling at its nuclear end point abrogates development in transgenic Xenopus embryos
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- Journal Article
- A1
- open access
Evolution of neural precursor selection: functional divergence of proneural proteins
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- Journal Article
- A1
- open access
P120 catenin is required for morphogenetic movements involved in the formation of the eyes and the cranlofacial skeleton in Xenopus
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The p120 catenin regulates morphogenetic movements in early xenopus embryos by modifying the activity of the rho-family small Gtpases.
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Modulation of invasion in vitro and in vivo
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Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer
(2002) Molecular and cellular basis for cell to cell interaction: its significance in cancer, p. 63-80 (S. Hirohashi, H.L. Moses, E. Ruoslahti, T. Sugimura, M. Takeichi and M. Terada, Eds.). Proceedings of the 24th International Symposium of the Princess Takamatsu Cancer Research Fund. The Princeton Scientific Publishing Co. Inc. Princeton, New Jersey, USA, 1994. -
Cell adhesion molecules
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Adhesive specificity and the evolution of multicellularity
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The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates.
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The C-terminal transactivation domain of β-catenin is necessary and sufficient for signaling by the LEF-1/β-catenin complex in Xenopus laevis
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Cadherins and tissue formation: integrating adhesion and signaling.
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Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis
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Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a fibroblastic (f) morphotype in culture.
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- Journal Article
- A1
- open access
Syndecan-1 expression in mammary epithelial tumor cells is E-cadherin-dependent.
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Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells
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Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer
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Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer
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MICRO-ENCAPSULATION OF MDCK-RAS-E CELLS PREVENTS LOSS OF E-CADHERIN INVASION-SUPPRESSOR FUNCTION IN-VIVO
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Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells
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Karakterisering van de cel-cel adhesiemolecule E-cadherine als invasie-suppressor eiwit in epitheliale tumorcellen
(1993) -
Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro.
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NEOPLASTIC PROGRESSION OF HUMAN AND RAT INTESTINAL-CELL LINES AFTER TRANSFER OF THE RAS AND POLYOMA MIDDLE T-ONCOGENES
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Modulation of invasion in vitro and in vivo
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Homotypic cell-cell adhesion molecules and tumor invasion
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The invasion suppressor role of E-cadherin
(1992) Metastasis : basic research and its clinical applications. In Contributions to Oncology 44. p.108-126 -
E-Cadherin expression: a counterbalance for cancer cell invasion.