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New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5.
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The allergen-induced airway hyperresponsiveness in a human-mouse chimera model of asthma is T cell and IL-4 and IL-5 dependent.
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Counterbalancing of T(H)2-driven allergic airway inflammation by IL-12 does not require IL-10.
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Cellular and molecular mechanisms of allergen induced airway inflammation and hyperresponsiveness
(2001) -
Gene knockout models of asthma
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Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness.
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House dust mite-induced airway changes in hu-SCID mice.
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Mouse strain and conditioning regimen determine survival and function of human leucocytes in immunodeficient mice.
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Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness.
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Cytokines and their receptors as therapeutic targets in asthma