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Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function
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Non-invasive method to obtain blood curves of 99mTc-mebrofenin
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In vivo visualization and quantification of (disturbed) Oatp-mediated hepatic uptake and Mrp2-mediated biliary excretion of 99mTc-mebrofenin in mice
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Molecular imaging as a non-invasive tool to visualize impaired hepatobiliary transporter function in Oatp1a/1b and Mrp2 knock-out mice
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In vivo µSPECT visualization of transport-mediated hepatic uptake and efflux of 99mTc-mebrofenin, and inhibition thereof with rifampicin