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The citrus flavonoid tangeretin inhibits invasion of human breast cancer cells
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hMSH6 deficiency and inactivation of the alpha E-catenin invasion-suppressor gene in HCT-8 colon cancer cells.
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Mutation of alpha-catenin results in invasiveness of human HCT-8 colon cancer cells.
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Functional downregulation of the E-cadherin/catenin complex leads to loss of contact inhibition of motility and of mitochondrial activity, but not of growth in confluent epithelial cell cultures
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CITRUS FLAVONOID EFFECT ON TUMOR INVASION AND METASTASIS.