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Phenotype of patients responsive to occipital nerve stimulation for refractory head pain

Koen Paemeleire UGent, Jean-Pierre Van Buyten, Machteld Van Buynder, Dario Alicino, GEORGES VAN MAELE UGent, Iris Smet and Peter Goadsby (2010) CEPHALALGIA. 30(6). p.662-673
abstract
Occipital nerve stimulation (ONS) has been employed off-label for medically refractory head pain. Identification of specific headache diagnoses responding to this modality of treatment is required. Forty-four patients with medically refractory head pain and treated with ONS were invited to participate in a retrospective study including a clinical interview and, if necessary, an indomethacin test to establish the headache phenotype according to the International Classification of Headache Disorders, 2nd edn (ICHD-II). We gathered data from questionnaires before implantation, at 1 month after implantation, and at long-term follow-up. Twenty-six patients consented and were phenotyped. At 1 month follow-up and at long-term follow-up a significant decrease in all pain parameters was noted, as well as in analgesic use. Quality of sleep and quality of life improved. Patient satisfaction was generally high as 80% of patients had >= 50% pain relief at long-term follow-up. The overall complication rate was low, but revisions were frequent. After phenotyping, two main groups emerged: eight patients had 'Migraine without aura' (ICHD-II 1.1) and eight patients 'Constant pain caused by compression, irritation or distortion of cranial nerves or upper cervical roots by structural lesions' (ICHD-II 13.12). Overuse of symptomatic acute headache treatments was associated with less favourable long-term outcome in migraine patients. We conclude that careful clinical phenotyping may help in defining subgroups of patients with medically refractory headache that are more likely to respond to ONS. The data suggest medication overuse should be managed appropriately when considering ONS in migraine. A controlled prospective study for ONS in ICHD-II 13.12 is warranted.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Occipital neurostimulation, refractory headache, neuropathic pain, migraine, CHRONIC CLUSTER HEADACHE, TERM-FOLLOW-UP, PERIPHERAL NEUROSTIMULATION, ELECTRICAL-STIMULATION, HEMICRANIA CONTINUA, DISORDERS, NEURALGIA, MIGRAINE, EFFICACY, INPUT
journal title
CEPHALALGIA
Cephalalgia
volume
30
issue
6
pages
662 - 673
Web of Science type
Article
Web of Science id
000279282100005
JCR category
CLINICAL NEUROLOGY
JCR impact factor
4.265 (2010)
JCR rank
28/185 (2010)
JCR quartile
1 (2010)
ISSN
0333-1024
DOI
10.1111/j.1468-2982.2009.02022.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
991927
handle
http://hdl.handle.net/1854/LU-991927
date created
2010-06-29 13:42:52
date last changed
2015-06-17 11:27:05
@article{991927,
  abstract     = {Occipital nerve stimulation (ONS) has been employed off-label for medically refractory head pain. Identification of specific headache diagnoses responding to this modality of treatment is required. Forty-four patients with medically refractory head pain and treated with ONS were invited to participate in a retrospective study including a clinical interview and, if necessary, an indomethacin test to establish the headache phenotype according to the International Classification of Headache Disorders, 2nd edn (ICHD-II). We gathered data from questionnaires before implantation, at 1 month after implantation, and at long-term follow-up. Twenty-six patients consented and were phenotyped. At 1 month follow-up and at long-term follow-up a significant decrease in all pain parameters was noted, as well as in analgesic use. Quality of sleep and quality of life improved. Patient satisfaction was generally high as 80\% of patients had {\textrangle}= 50\% pain relief at long-term follow-up. The overall complication rate was low, but revisions were frequent. After phenotyping, two main groups emerged: eight patients had 'Migraine without aura' (ICHD-II 1.1) and eight patients 'Constant pain caused by compression, irritation or distortion of cranial nerves or upper cervical roots by structural lesions' (ICHD-II 13.12). Overuse of symptomatic acute headache treatments was associated with less favourable long-term outcome in migraine patients. We conclude that careful clinical phenotyping may help in defining subgroups of patients with medically refractory headache that are more likely to respond to ONS. The data suggest medication overuse should be managed appropriately when considering ONS in migraine. A controlled prospective study for ONS in ICHD-II 13.12 is warranted.},
  author       = {Paemeleire, Koen and Van Buyten, Jean-Pierre and Van Buynder, Machteld and Alicino, Dario and VAN MAELE, GEORGES and Smet, Iris and Goadsby, Peter},
  issn         = {0333-1024},
  journal      = {CEPHALALGIA},
  keyword      = {Occipital neurostimulation,refractory headache,neuropathic pain,migraine,CHRONIC CLUSTER HEADACHE,TERM-FOLLOW-UP,PERIPHERAL NEUROSTIMULATION,ELECTRICAL-STIMULATION,HEMICRANIA CONTINUA,DISORDERS,NEURALGIA,MIGRAINE,EFFICACY,INPUT},
  language     = {eng},
  number       = {6},
  pages        = {662--673},
  title        = {Phenotype of patients responsive to occipital nerve stimulation for refractory head pain},
  url          = {http://dx.doi.org/10.1111/j.1468-2982.2009.02022.x},
  volume       = {30},
  year         = {2010},
}

Chicago
Paemeleire, Koen, Jean-Pierre Van Buyten, Machteld Van Buynder, Dario Alicino, Georges Van Maele, Iris Smet, and Peter Goadsby. 2010. “Phenotype of Patients Responsive to Occipital Nerve Stimulation for Refractory Head Pain.” Cephalalgia 30 (6): 662–673.
APA
Paemeleire, K., Van Buyten, J.-P., Van Buynder, M., Alicino, D., Van Maele, G., Smet, I., & Goadsby, P. (2010). Phenotype of patients responsive to occipital nerve stimulation for refractory head pain. CEPHALALGIA, 30(6), 662–673.
Vancouver
1.
Paemeleire K, Van Buyten J-P, Van Buynder M, Alicino D, Van Maele G, Smet I, et al. Phenotype of patients responsive to occipital nerve stimulation for refractory head pain. CEPHALALGIA. 2010;30(6):662–73.
MLA
Paemeleire, Koen, Jean-Pierre Van Buyten, Machteld Van Buynder, et al. “Phenotype of Patients Responsive to Occipital Nerve Stimulation for Refractory Head Pain.” CEPHALALGIA 30.6 (2010): 662–673. Print.