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Differences in the glucose-induced insulin response and the peripheral insulin responsiveness between neonatal calves of the Belgian Blue, Holstein-Friesian, and East Flemish breeds

Philippe Bossaert UGent, J.L.M.R. Leroy, S. De Campeneere, Sarne De Vliegher UGent and Geert Opsomer UGent (2009) JOURNAL OF DAIRY SCIENCE. 92(9). p.4401-4411
abstract
Decreased insulin sensitivity (IS) in dairy cows supports milk yield but increases the risk for metabolic and reproductive disorders. Although several inducers of decreased IS are known, it is unclear to what extent it is congenitally determined. The main aim was to investigate differences in IS between neonatal calves of the Belgian Blue (BB) breed, reared for beef production, and the Holstein-Friesian (HF) breed, reared for milk yield. Additionally, a small number of East Flemish (EF) calves, a local dual-purpose breed, were compared with the 2 other breeds. Ten BB, 12 HF, and 4 EF calves with similar age, ration, and housing were selected. In the intravenous glucose tolerance test, blood samples were taken at regular intervals after an intravenous glucose bolus of 150 mg/kg. Area under the curve (AUC), peak concentration, and elimination rate of insulin and glucose were computed. The quantitative insulin sensitivity check index (QUICKI) and revised QUICKI were computed using basal glucose, insulin, and nonesterified fatty acid concentrations. In the intravenous insulin tolerance test, blood samples were obtained from 4 calves of each breed at regular times after an intravenous insulin challenge of 0.05 IU/kg. Based on the decline in glucose concentrations relative to basal levels, the insulin-stimulated blood glucose response was computed. Basal insulin concentrations were higher in HF (1.58 +/- 0.40 mu U/mL) than in BB calves (0.35 +/- 0.09 mmol/L). Compared with BB calves, HF and EF calves had higher basal glucose concentrations (4.40 +/- 0.16 vs. 5.70 +/- 0.35 and 5.81 +/- 0.13 mmol/L, respectively), insulin peak concentrations (4.62 +/- 1.09 vs. 9.70 +/- 1.45 and 16.44 +/- 5.58 mu U/mL, respectively), insulin AUC (86.71 +/- 18.81 vs. 222.65 +/- 45.00 and 293.69 +/- 109.22 mu U/mL.min, respectively), and glucose AUC (256.22 +/- 17.53 vs. 335.66 +/- 18.74 and 321.03 +/- 10.05 mmol/L.min, respectively). Glucose elimination rates were lower in HF (1.37 +/- 0.22%/min) than in BB calves (2.35 +/- 0.25%/min). The QUICKI was lower in HF and EF than in BB calves (0.52 +/- 0.039 and 0.57 +/- 0.068 vs. 0.76 +/- 0.038, respectively), and the revised QUICKI was lower in HF (0.86 +/- 0.11) than in BB calves (1.59 +/- 0.17). The insulin-stimulated blood glucose response did not differ between breeds. Because management differences were negligible, our results suggest breed-specific differences in glucose partitioning and IS. These findings may reflect different rearing purposes of the breeds, although extrapolation of the data to adult animals should be done cautiously.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
congenital, dairy cow, insulin sensitivity, neonatal calf
journal title
JOURNAL OF DAIRY SCIENCE
J. Dairy Sci.
volume
92
issue
9
pages
4401 - 4411
Web of Science type
article
Web of Science id
000269156600030
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
2.463 (2009)
JCR rank
2/49 (2009)
JCR quartile
1 (2009)
ISSN
0022-0302
language
English
UGent publication?
yes
classification
A1
additional info
FT N/A
id
988882
handle
http://hdl.handle.net/1854/LU-988882
date created
2010-06-28 08:46:58
date last changed
2010-07-01 12:20:53
@article{988882,
  abstract     = {Decreased insulin sensitivity (IS) in dairy cows supports milk yield but increases the risk for metabolic and reproductive disorders. Although several inducers of decreased IS are known, it is unclear to what extent it is congenitally determined. The main aim was to investigate differences in IS between neonatal calves of the Belgian Blue (BB) breed, reared for beef production, and the Holstein-Friesian (HF) breed, reared for milk yield. Additionally, a small number of East Flemish (EF) calves, a local dual-purpose breed, were compared with the 2 other breeds. Ten BB, 12 HF, and 4 EF calves with similar age, ration, and housing were selected. In the intravenous glucose tolerance test, blood samples were taken at regular intervals after an intravenous glucose bolus of 150 mg/kg. Area under the curve (AUC), peak concentration, and elimination rate of insulin and glucose were computed. The quantitative insulin sensitivity check index (QUICKI) and revised QUICKI were computed using basal glucose, insulin, and nonesterified fatty acid concentrations. In the intravenous insulin tolerance test, blood samples were obtained from 4 calves of each breed at regular times after an intravenous insulin challenge of 0.05 IU/kg. Based on the decline in glucose concentrations relative to basal levels, the insulin-stimulated blood glucose response was computed. Basal insulin concentrations were higher in HF (1.58 +/- 0.40 mu U/mL) than in BB calves (0.35 +/- 0.09 mmol/L). Compared with BB calves, HF and EF calves had higher basal glucose concentrations (4.40 +/- 0.16 vs. 5.70 +/- 0.35 and 5.81 +/- 0.13 mmol/L, respectively), insulin peak concentrations (4.62 +/- 1.09 vs. 9.70 +/- 1.45 and 16.44 +/- 5.58 mu U/mL, respectively), insulin AUC (86.71 +/- 18.81 vs. 222.65 +/- 45.00 and 293.69 +/- 109.22 mu U/mL.min, respectively), and glucose AUC (256.22 +/- 17.53 vs. 335.66 +/- 18.74 and 321.03 +/- 10.05 mmol/L.min, respectively). Glucose elimination rates were lower in HF (1.37 +/- 0.22\%/min) than in BB calves (2.35 +/- 0.25\%/min). The QUICKI was lower in HF and EF than in BB calves (0.52 +/- 0.039 and 0.57 +/- 0.068 vs. 0.76 +/- 0.038, respectively), and the revised QUICKI was lower in HF (0.86 +/- 0.11) than in BB calves (1.59 +/- 0.17). The insulin-stimulated blood glucose response did not differ between breeds. Because management differences were negligible, our results suggest breed-specific differences in glucose partitioning and IS. These findings may reflect different rearing purposes of the breeds, although extrapolation of the data to adult animals should be done cautiously.},
  author       = {Bossaert, Philippe and Leroy, J.L.M.R. and De Campeneere, S. and De Vliegher, Sarne and Opsomer, Geert},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keyword      = {congenital,dairy cow,insulin sensitivity,neonatal calf},
  language     = {eng},
  number       = {9},
  pages        = {4401--4411},
  title        = {Differences in the glucose-induced insulin response and the peripheral insulin responsiveness between neonatal calves of the Belgian Blue, Holstein-Friesian, and East Flemish breeds},
  volume       = {92},
  year         = {2009},
}

Chicago
Bossaert, Philippe, J.L.M.R. Leroy, S. De Campeneere, Sarne De Vliegher, and Geert Opsomer. 2009. “Differences in the Glucose-induced Insulin Response and the Peripheral Insulin Responsiveness Between Neonatal Calves of the Belgian Blue, Holstein-Friesian, and East Flemish Breeds.” Journal of Dairy Science 92 (9): 4401–4411.
APA
Bossaert, Philippe, Leroy, J. L. M. R., De Campeneere, S., De Vliegher, S., & Opsomer, G. (2009). Differences in the glucose-induced insulin response and the peripheral insulin responsiveness between neonatal calves of the Belgian Blue, Holstein-Friesian, and East Flemish breeds. JOURNAL OF DAIRY SCIENCE, 92(9), 4401–4411.
Vancouver
1.
Bossaert P, Leroy JLMR, De Campeneere S, De Vliegher S, Opsomer G. Differences in the glucose-induced insulin response and the peripheral insulin responsiveness between neonatal calves of the Belgian Blue, Holstein-Friesian, and East Flemish breeds. JOURNAL OF DAIRY SCIENCE. 2009;92(9):4401–11.
MLA
Bossaert, Philippe, J.L.M.R. Leroy, S. De Campeneere, et al. “Differences in the Glucose-induced Insulin Response and the Peripheral Insulin Responsiveness Between Neonatal Calves of the Belgian Blue, Holstein-Friesian, and East Flemish Breeds.” JOURNAL OF DAIRY SCIENCE 92.9 (2009): 4401–4411. Print.