Advanced search
1 file | 203.80 KB Add to list

Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review

Author
Organization
Abstract
Cystic ovarian follicles ( COF) are an important ovarian dysfunction and a major cause of reproductive failure in dairy cattle. Due to the complexity of the disorder and the heterogeneity of the clinical signs, a clear definition is lacking. A follicle becomes cystic when it fails to ovulate and persists on the ovary. Despite an abundance of literature on the subject, the exact pathogenesis of COF is unclear. It is generally accepted that disruption of the hypothalamo-pituitary-gonadal axis, by endogenous and/or exogenous factors, causes cyst formation. Secretion of GnRH/LH from the hypothalamus-pituitary is aberrant, which is attributed to insensitivity of the hypothalamus-pituitary to the positive feedback effect of oestrogens. In addition, several factors can influence GnRH/LH release at the hypothalamo-pituitary level. At the ovarian level, cellular and molecular changes in the growing follicle may contribute to anovulation and cyst formation, but studying follicular changes prior to cyst formation remains extremely difficult. Differences in receptor expression between COF and dominant follicles may be an indication of the pathways involved in cyst formation. The genotypic and phenotypic link of COF with milk yield may be attributed to negative energy balance and the associated metabolic and hormonal adaptations. Altered metabolite and hormone concentrations may influence follicle growth and cyst development, both at the level of the hypothalamus-pituitary and the ovarian level.
Keywords
hypothalamus-pituitary, pathogenesis, negative energy balance, ovary, cystic ovarian follicles, ESTROGEN RECEPTOR-BETA, FREE FATTY-ACIDS, GONADOTROPIN-RELEASING-HORMONE, GROWTH-FACTOR-I, FOLLICULAR CYSTS, LUTEINIZING-HORMONE, HOLSTEIN COWS, GRANULOSA-CELLS, RISK-FACTORS, POST-PARTUM

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 203.80 KB

Citation

Please use this url to cite or link to this publication:

MLA
Vanholder, Tom, Geert Opsomer, and Aart de Kruif. “Aetiology and Pathogenesis of Cystic Ovarian Follicles in Dairy Cattle: a Review.” REPRODUCTION NUTRITION DEVELOPMENT 46.2 (2006): 105–119. Print.
APA
Vanholder, Tom, Opsomer, G., & de Kruif, A. (2006). Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review. REPRODUCTION NUTRITION DEVELOPMENT, 46(2), 105–119.
Chicago author-date
Vanholder, Tom, Geert Opsomer, and Aart de Kruif. 2006. “Aetiology and Pathogenesis of Cystic Ovarian Follicles in Dairy Cattle: a Review.” Reproduction Nutrition Development 46 (2): 105–119.
Chicago author-date (all authors)
Vanholder, Tom, Geert Opsomer, and Aart de Kruif. 2006. “Aetiology and Pathogenesis of Cystic Ovarian Follicles in Dairy Cattle: a Review.” Reproduction Nutrition Development 46 (2): 105–119.
Vancouver
1.
Vanholder T, Opsomer G, de Kruif A. Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review. REPRODUCTION NUTRITION DEVELOPMENT. 2006;46(2):105–19.
IEEE
[1]
T. Vanholder, G. Opsomer, and A. de Kruif, “Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review,” REPRODUCTION NUTRITION DEVELOPMENT, vol. 46, no. 2, pp. 105–119, 2006.
@article{986986,
  abstract     = {Cystic ovarian follicles ( COF) are an important ovarian dysfunction and a major cause of reproductive failure in dairy cattle. Due to the complexity of the disorder and the heterogeneity of the clinical signs, a clear definition is lacking. A follicle becomes cystic when it fails to ovulate and persists on the ovary. Despite an abundance of literature on the subject, the exact pathogenesis of COF is unclear. It is generally accepted that disruption of the hypothalamo-pituitary-gonadal axis, by endogenous and/or exogenous factors, causes cyst formation. Secretion of GnRH/LH from the hypothalamus-pituitary is aberrant, which is attributed to insensitivity of the hypothalamus-pituitary to the positive feedback effect of oestrogens. In addition, several factors can influence GnRH/LH release at the hypothalamo-pituitary level. At the ovarian level, cellular and molecular changes in the growing follicle may contribute to anovulation and cyst formation, but studying follicular changes prior to cyst formation remains extremely difficult. Differences in receptor expression between COF and dominant follicles may be an indication of the pathways involved in cyst formation. The genotypic and phenotypic link of COF with milk yield may be attributed to negative energy balance and the associated metabolic and hormonal adaptations. Altered metabolite and hormone concentrations may influence follicle growth and cyst development, both at the level of the hypothalamus-pituitary and the ovarian level.},
  author       = {Vanholder, Tom and Opsomer, Geert and de Kruif, Aart},
  issn         = {0926-5287},
  journal      = {REPRODUCTION NUTRITION DEVELOPMENT},
  keywords     = {hypothalamus-pituitary,pathogenesis,negative energy balance,ovary,cystic ovarian follicles,ESTROGEN RECEPTOR-BETA,FREE FATTY-ACIDS,GONADOTROPIN-RELEASING-HORMONE,GROWTH-FACTOR-I,FOLLICULAR CYSTS,LUTEINIZING-HORMONE,HOLSTEIN COWS,GRANULOSA-CELLS,RISK-FACTORS,POST-PARTUM},
  language     = {eng},
  number       = {2},
  pages        = {105--119},
  title        = {Aetiology and pathogenesis of cystic ovarian follicles in dairy cattle: a review},
  url          = {http://dx.doi.org/10.1051/rnd:2006003},
  volume       = {46},
  year         = {2006},
}

Altmetric
View in Altmetric
Web of Science
Times cited: