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Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003-2007

(2010) TRANSPLANT INTERNATIONAL. 23(6). p.611-618
Author
Organization
Abstract
The Belgian experience with donation after cardiac death (DCD) liver transplantation (LT) was retrospectively reviewed, particularly evaluating patient and graft survivals, and biliary complications. From 2003 to 2007, 58 DCD-LT were performed in Belgium. Mean procurement total warm ischemia time was 25 +/- 2 min (mean +/- SEM). Mean cold ischemia time was 451 +/- 18 min. Mean follow-up was 23 +/- 2.2 months. Post-transplant peak aspartate aminotransminases was 2241 +/- 338 UI/l. Patient survivals at 1 month, 1 and 3 years, were 91.3%, 83.3% and 66.9% respectively. Graft survivals at 1 month, 1 and 3 years, were 84.4%, 72.4% and 48.8% respectively. Two patients (3.4%) developed primary nonfunction. Regarding the biliary complications, seven grafts (12%) were lost because of intrahepatic cholangiopathy, and 12 other patients (20.6%) developed bile duct stenoses requiring endoscopic and/or surgical management. The rate of symptomatic ischemic biliary lesions for grafts surviving more than 3 months was 38% (19/50). Although DCD organ donors may be a source of viable liver grafts, results were inferior to those obtained with donation after brain death LT in this series. Prognostic criteria have to be developed to improve results of DCD-LT.
Keywords
BILIARY COMPLICATIONS, ORGAN PROCUREMENT, SINGLE-CENTER EXPERIENCE, HEART-BEATING DONORS, CONTROLLED NONHEARTBEATING DONORS, graft outcome, nonheart beating donation, ischemic bile duct lesion, graft failure, extended donor criteria, LONG, GRAFT-SURVIVAL, UNIVERSITY, OUTCOMES

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Citation

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MLA
Detry, Olivier et al. “Liver Transplantation from Donation After Cardiac Death Donors: Initial Belgian Experience 2003-2007.” TRANSPLANT INTERNATIONAL 23.6 (2010): 611–618. Print.
APA
Detry, Olivier, Donckier de Donceel, V., Lucidi, V., Ysebaert, D., Chapelle, T., Lerut, J., Ciccarelli, O., et al. (2010). Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003-2007. TRANSPLANT INTERNATIONAL, 23(6), 611–618.
Chicago author-date
Detry, Olivier, Vincent Donckier de Donceel, Valerio Lucidi, Dirk Ysebaert, Thiery Chapelle, Jan Lerut, Olga Ciccarelli, et al. 2010. “Liver Transplantation from Donation After Cardiac Death Donors: Initial Belgian Experience 2003-2007.” Transplant International 23 (6): 611–618.
Chicago author-date (all authors)
Detry, Olivier, Vincent Donckier de Donceel, Valerio Lucidi, Dirk Ysebaert, Thiery Chapelle, Jan Lerut, Olga Ciccarelli, Jacques Pirenne, Diethard Monbaliu, Arnaud De Roover, Pierre Honore, Xavier Rogiers, Bernard de Hemptinne, and Roberto Troisi. 2010. “Liver Transplantation from Donation After Cardiac Death Donors: Initial Belgian Experience 2003-2007.” Transplant International 23 (6): 611–618.
Vancouver
1.
Detry O, Donckier de Donceel V, Lucidi V, Ysebaert D, Chapelle T, Lerut J, et al. Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003-2007. TRANSPLANT INTERNATIONAL. 2010;23(6):611–8.
IEEE
[1]
O. Detry et al., “Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003-2007,” TRANSPLANT INTERNATIONAL, vol. 23, no. 6, pp. 611–618, 2010.
@article{982462,
  abstract     = {The Belgian experience with donation after cardiac death (DCD) liver transplantation (LT) was retrospectively reviewed, particularly evaluating patient and graft survivals, and biliary complications. From 2003 to 2007, 58 DCD-LT were performed in Belgium. Mean procurement total warm ischemia time was 25 +/- 2 min (mean +/- SEM). Mean cold ischemia time was 451 +/- 18 min. Mean follow-up was 23 +/- 2.2 months. Post-transplant peak aspartate aminotransminases was 2241 +/- 338 UI/l. Patient survivals at 1 month, 1 and 3 years, were 91.3%, 83.3% and 66.9% respectively. Graft survivals at 1 month, 1 and 3 years, were 84.4%, 72.4% and 48.8% respectively. Two patients (3.4%) developed primary nonfunction. Regarding the biliary complications, seven grafts (12%) were lost because of intrahepatic cholangiopathy, and 12 other patients (20.6%) developed bile duct stenoses requiring endoscopic and/or surgical management. The rate of symptomatic ischemic biliary lesions for grafts surviving more than 3 months was 38% (19/50). Although DCD organ donors may be a source of viable liver grafts, results were inferior to those obtained with donation after brain death LT in this series. Prognostic criteria have to be developed to improve results of DCD-LT.},
  author       = {Detry, Olivier and Donckier de Donceel, Vincent and Lucidi, Valerio and Ysebaert, Dirk and Chapelle, Thiery and Lerut, Jan and Ciccarelli, Olga and Pirenne, Jacques and Monbaliu, Diethard and De Roover, Arnaud and Honore, Pierre and Rogiers, Xavier and de Hemptinne, Bernard and Troisi, Roberto},
  issn         = {0934-0874},
  journal      = {TRANSPLANT INTERNATIONAL},
  keywords     = {BILIARY COMPLICATIONS,ORGAN PROCUREMENT,SINGLE-CENTER EXPERIENCE,HEART-BEATING DONORS,CONTROLLED NONHEARTBEATING DONORS,graft outcome,nonheart beating donation,ischemic bile duct lesion,graft failure,extended donor criteria,LONG,GRAFT-SURVIVAL,UNIVERSITY,OUTCOMES},
  language     = {eng},
  number       = {6},
  pages        = {611--618},
  title        = {Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003-2007},
  url          = {http://dx.doi.org/10.1111/j.1432-2277.2009.01029.x},
  volume       = {23},
  year         = {2010},
}

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