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Folates and folic acid: from fundamental research toward sustainable health

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Abstract
Folates are of paramount importance in one-carbon metabolism of most organisms. Plants and microorganisms are able to synthesize folates de novo, making them the main dietary source for humans and animals, which are dependent on food or feed supplies for folates. Folate deficiency is an increasing problem in the developing, as well as in the developed regions of the world, affecting millions of people. Different strategies, such as food fortification and folic acid supplementation, remain far from accessible for the poor rural populations in developing countries. Increasing knowledge concerning folate biosynthesis, transport and catabolism does not only deepen our insight on the regulation of folate metabolism but also provides the keys towards folate enhancement through metabolic engineering in bacteria, as well as in plants. Recently, promising results were obtained using such an approach, but further fundamental research is a prerequisite to develop a practicable solution to fight folate deficiency. In parallel, progress in the development and improvement of folate analysis has been made. Here, we provide the state-of-the-art of folate biosynthesis, catabolism, and salvage. Finally, we report on progress in folate biofortification and discuss the agroeconomical aspect of biofortified crop plants.
Keywords
NEURAL-TUBE DEFECTS, CELL-FREE EXTRACTS, GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE, GAMMA-GLUTAMYL HYDROLASES, REDUCTASE-THYMIDYLATE SYNTHASE, PARA-AMINOBENZOATE SYNTHESIS, natural variation, agroeconomics, neural tube defects, GTP CYCLOHYDROLASE-I, metabolic engineering, biofortification, ONE-CARBON METABOLISM, PRECURSOR P-AMINOBENZOATE, PARASITE LEISHMANIA-MAJOR

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MLA
Blancquaert, Dieter et al. “Folates and Folic Acid: From Fundamental Research Toward Sustainable Health.” CRITICAL REVIEWS IN PLANT SCIENCES 29.1 (2010): 14–35. Print.
APA
Blancquaert, D., Storojenko, S., Loizeau, K., De Steur, H., De Brouwer, V., Viaene, J., Ravanel, S., et al. (2010). Folates and folic acid: from fundamental research toward sustainable health. CRITICAL REVIEWS IN PLANT SCIENCES, 29(1), 14–35.
Chicago author-date
Blancquaert, Dieter, Serguei Storojenko, Karen Loizeau, Hans De Steur, Veerle De Brouwer, Jacques Viaene, Stéphane Ravanel, Fabrice Rébeillé, Willy Lambert, and Dominique Van Der Straeten. 2010. “Folates and Folic Acid: From Fundamental Research Toward Sustainable Health.” Critical Reviews in Plant Sciences 29 (1): 14–35.
Chicago author-date (all authors)
Blancquaert, Dieter, Serguei Storojenko, Karen Loizeau, Hans De Steur, Veerle De Brouwer, Jacques Viaene, Stéphane Ravanel, Fabrice Rébeillé, Willy Lambert, and Dominique Van Der Straeten. 2010. “Folates and Folic Acid: From Fundamental Research Toward Sustainable Health.” Critical Reviews in Plant Sciences 29 (1): 14–35.
Vancouver
1.
Blancquaert D, Storojenko S, Loizeau K, De Steur H, De Brouwer V, Viaene J, et al. Folates and folic acid: from fundamental research toward sustainable health. CRITICAL REVIEWS IN PLANT SCIENCES. 2010;29(1):14–35.
IEEE
[1]
D. Blancquaert et al., “Folates and folic acid: from fundamental research toward sustainable health,” CRITICAL REVIEWS IN PLANT SCIENCES, vol. 29, no. 1, pp. 14–35, 2010.
@article{980368,
  abstract     = {{Folates are of paramount importance in one-carbon metabolism of most organisms. Plants and microorganisms are able to synthesize folates de novo, making them the main dietary source for humans and animals, which are dependent on food or feed supplies for folates. Folate deficiency is an increasing problem in the developing, as well as in the developed regions of the world, affecting millions of people. Different strategies, such as food fortification and folic acid supplementation, remain far from accessible for the poor rural populations in developing countries. Increasing knowledge concerning folate biosynthesis, transport and catabolism does not only deepen our insight on the regulation of folate metabolism but also provides the keys towards folate enhancement through metabolic engineering in bacteria, as well as in plants. Recently, promising results were obtained using such an approach, but further fundamental research is a prerequisite to develop a practicable solution to fight folate deficiency. In parallel, progress in the development and improvement of folate analysis has been made. Here, we provide the state-of-the-art of folate biosynthesis, catabolism, and salvage. Finally, we report on progress in folate biofortification and discuss the agroeconomical aspect of biofortified crop plants.}},
  author       = {{Blancquaert, Dieter and Storojenko, Serguei and Loizeau, Karen and De Steur, Hans and De Brouwer, Veerle and Viaene, Jacques and Ravanel, Stéphane and Rébeillé, Fabrice and Lambert, Willy and Van Der Straeten, Dominique}},
  issn         = {{0735-2689}},
  journal      = {{CRITICAL REVIEWS IN PLANT SCIENCES}},
  keywords     = {{NEURAL-TUBE DEFECTS,CELL-FREE EXTRACTS,GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE,GAMMA-GLUTAMYL HYDROLASES,REDUCTASE-THYMIDYLATE SYNTHASE,PARA-AMINOBENZOATE SYNTHESIS,natural variation,agroeconomics,neural tube defects,GTP CYCLOHYDROLASE-I,metabolic engineering,biofortification,ONE-CARBON METABOLISM,PRECURSOR P-AMINOBENZOATE,PARASITE LEISHMANIA-MAJOR}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{14--35}},
  title        = {{Folates and folic acid: from fundamental research toward sustainable health}},
  url          = {{http://dx.doi.org/10.1080/07352680903436283}},
  volume       = {{29}},
  year         = {{2010}},
}

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