Characterizing regulatory path motifs in integrated networks using perturbational data
(2010) GENOME BIOLOGY. 11(3).- abstract
- We introduce Pathicular http://bioinformatics.psb.ugent.be/software/details/Pathicular, a Cytoscape plugin for studying the cellular response to perturbations of transcription factors by integrating perturbational expression data with transcriptional, protein-protein and phosphorylation networks. Pathicular searches for 'regulatory path motifs', short paths in the integrated physical networks which occur significantly more often than expected between transcription factors and their targets in the perturbational data. A case study in Saccharomyces cerevisiae identifies eight regulatory path motifs and demonstrates their biological significance.
Please use this url to cite or link to this publication:
http://hdl.handle.net/1854/LU-980143
- author
- Anagha Madhusudan Joshi UGent, Thomas Van Parys UGent, Yves Van de Peer UGent and Tom Michoel UGent
- organization
- alternative title
- Software : Characterizing regulatory path motifs in integrated networks using perturbational data
- year
- 2010
- type
- journalArticle (original)
- publication status
- published
- subject
- keyword
- GENOME, YEAST, GENE-EXPRESSION, TRANSCRIPTIONAL REGULATION, ESCHERICHIA-COLI, CELL-CYCLE, SACCHAROMYCES-CEREVISIAE, COMPLEX, DNA, PHOSPHORYLATION
- journal title
- GENOME BIOLOGY
- Genome Biol.
- volume
- 11
- issue
- 3
- article_number
- R32
- pages
- 14 pages
- Web of Science type
- Article
- Web of Science id
- 000277309100018
- ISSN
- 1474-760X
- DOI
- 10.1186/gb-2010-11-3-r32
- language
- English
- UGent publication?
- yes
- classification
- A1
- copyright statement
- I have retained and own the full copyright for this publication
- id
- 980143
- handle
- http://hdl.handle.net/1854/LU-980143
- date created
- 2010-06-17 14:44:08
- date last changed
- 2012-09-03 14:21:04
@article{980143,
abstract = {We introduce Pathicular http://bioinformatics.psb.ugent.be/software/details/Pathicular, a Cytoscape plugin for studying the cellular response to perturbations of transcription factors by integrating perturbational expression data with transcriptional, protein-protein and phosphorylation networks. Pathicular searches for 'regulatory path motifs', short paths in the integrated physical networks which occur significantly more often than expected between transcription factors and their targets in the perturbational data. A case study in Saccharomyces cerevisiae identifies eight regulatory path motifs and demonstrates their biological significance.},
articleno = {R32},
author = {Joshi, Anagha Madhusudan and Van Parys, Thomas and Van de Peer, Yves and Michoel, Tom},
issn = {1474-760X},
journal = {GENOME BIOLOGY},
keyword = {GENOME,YEAST,GENE-EXPRESSION,TRANSCRIPTIONAL REGULATION,ESCHERICHIA-COLI,CELL-CYCLE,SACCHAROMYCES-CEREVISIAE,COMPLEX,DNA,PHOSPHORYLATION},
language = {eng},
number = {3},
pages = {14},
title = {Characterizing regulatory path motifs in integrated networks using perturbational data},
url = {http://dx.doi.org/10.1186/gb-2010-11-3-r32},
volume = {11},
year = {2010},
}
- Chicago
- Joshi, Anagha Madhusudan, Thomas Van Parys, Yves Van de Peer, and Tom Michoel. 2010. “Characterizing Regulatory Path Motifs in Integrated Networks Using Perturbational Data.” Genome Biology 11 (3).
- APA
- Joshi, A. M., Van Parys, T., Van de Peer, Y., & Michoel, T. (2010). Characterizing regulatory path motifs in integrated networks using perturbational data. GENOME BIOLOGY, 11(3).
- Vancouver
- 1.Joshi AM, Van Parys T, Van de Peer Y, Michoel T. Characterizing regulatory path motifs in integrated networks using perturbational data. GENOME BIOLOGY. 2010;11(3).
- MLA
- Joshi, Anagha Madhusudan, Thomas Van Parys, Yves Van de Peer, et al. “Characterizing Regulatory Path Motifs in Integrated Networks Using Perturbational Data.” GENOME BIOLOGY 11.3 (2010): n. pag. Print.