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Elongator, a conserved multitasking complex?

Wim Versées, Steven De Groeve UGent and Maria Van Lijsebettens UGent (2010) MOLECULAR MICROBIOLOGY. 76(5). p.1065-1069
abstract
Post-transcriptional modifications on transfer RNA (tRNA) molecules occur frequently but their implication on the translational regulation is only recently becoming fully appreciated. Several tRNA molecules in the eukaryotic cytoplasm carry a methoxycarbonylmethyl (mcm) or carbamoylmethyl (ncm) group on their wobble uridine to ensure the efficient and reliable decoding of A- or G-ending codons. Evidence suggests that the six subunits of the conserved Elongator complex are all required for an early step in the synthesis of the mcm and ncm groups in Saccharomyces cerevisiae as well as in Caenorhabditis elegans. In this issue of Molecular Microbiology, Mehlgarten et al. convincingly show that the tRNA-modifying role of Elongator is also conserved in the plant Arabidopsis thaliana. Moreover, combinations of subunits of the Arabidopsis Elongator complex can structurally and functionally complement deletion mutants in yeast and substitute for the tRNA modification activity. The data suggest that Elongator might be a unique multitasking complex with at least two conserved roles in all eukaryotes, i.e. transcriptional activation via histone acetylation in the nucleus and translational control through tRNA modification in the cytoplasm.
Please use this url to cite or link to this publication:
author
organization
year
type
misc (editorialMaterial)
publication status
published
subject
keyword
CELL, DISEASE, HOLOENZYME, TRANSCRIPTION, ACETYLTRANSFERASE, TRANSFER-RNA, EXOCYTOSIS
in
MOLECULAR MICROBIOLOGY
Mol. Microbiol.
volume
76
issue
5
pages
1065 - 1069
Web of Science type
Editorial Material
Web of Science id
000277981100001
JCR category
MICROBIOLOGY
JCR impact factor
4.819 (2010)
JCR rank
16/103 (2010)
JCR quartile
1 (2010)
ISSN
0950-382X
DOI
10.1111/j.1365-2958.2010.07162.x
language
English
UGent publication?
yes
classification
V
copyright statement
I have transferred the copyright for this publication to the publisher
id
980131
handle
http://hdl.handle.net/1854/LU-980131
date created
2010-06-17 14:41:14
date last changed
2012-09-19 14:04:07
@misc{980131,
  abstract     = {Post-transcriptional modifications on transfer RNA (tRNA) molecules occur frequently but their implication on the translational regulation is only recently becoming fully appreciated. Several tRNA molecules in the eukaryotic cytoplasm carry a methoxycarbonylmethyl (mcm) or carbamoylmethyl (ncm) group on their wobble uridine to ensure the efficient and reliable decoding of A- or G-ending codons. Evidence suggests that the six subunits of the conserved Elongator complex are all required for an early step in the synthesis of the mcm and ncm groups in Saccharomyces cerevisiae as well as in Caenorhabditis elegans. In this issue of Molecular Microbiology, Mehlgarten et al. convincingly show that the tRNA-modifying role of Elongator is also conserved in the plant Arabidopsis thaliana. Moreover, combinations of subunits of the Arabidopsis Elongator complex can structurally and functionally complement deletion mutants in yeast and substitute for the tRNA modification activity. The data suggest that Elongator might be a unique multitasking complex with at least two conserved roles in all eukaryotes, i.e. transcriptional activation via histone acetylation in the nucleus and translational control through tRNA modification in the cytoplasm.},
  author       = {Vers{\'e}es, Wim and De Groeve, Steven and Van Lijsebettens, Maria},
  issn         = {0950-382X},
  keyword      = {CELL,DISEASE,HOLOENZYME,TRANSCRIPTION,ACETYLTRANSFERASE,TRANSFER-RNA,EXOCYTOSIS},
  language     = {eng},
  number       = {5},
  pages        = {1065--1069},
  series       = {MOLECULAR MICROBIOLOGY},
  title        = {Elongator, a conserved multitasking complex?},
  url          = {http://dx.doi.org/10.1111/j.1365-2958.2010.07162.x},
  volume       = {76},
  year         = {2010},
}

Chicago
Versées, Wim, Steven De Groeve, and Maria Van Lijsebettens. 2010. “Elongator, a Conserved Multitasking Complex?” Molecular Microbiology.
APA
Versées, W., De Groeve, S., & Van Lijsebettens, M. (2010). Elongator, a conserved multitasking complex? MOLECULAR MICROBIOLOGY.
Vancouver
1.
Versées W, De Groeve S, Van Lijsebettens M. Elongator, a conserved multitasking complex? MOLECULAR MICROBIOLOGY. 2010. p. 1065–9.
MLA
Versées, Wim, Steven De Groeve, and Maria Van Lijsebettens. “Elongator, a Conserved Multitasking Complex?” MOLECULAR MICROBIOLOGY 2010 : 1065–1069. Print.