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Localization of erythropoietin in and around growing cartilage

(2010) MOLECULAR AND CELLULAR BIOCHEMISTRY. 337(1-2). p.287-291
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Abstract
Erythropoietin (EPO) is known to be a hematopoietic growth factor and a regulator of red blood cell production. Recently, EPO has also been reported to function as a tissue-protective cytokine and as an angiogenesis promoting factor. EPO is mainly regulated by hypoxia through the action of hypoxia inducible factors (HIF-1 alpha and HIF-2 alpha). The localization of the EPO protein and the HIF-2 alpha protein were immunohistochemically analyzed in developing porcine embryos. Both proteins were localized in developing cartilage tissue. HIF-2 alpha and EPO protein were expressed in the peripheral chondrocytes of cartilage anlagen, in the perichondrium and in the cell condensations that will eventually differentiate into cartilage tissue. The results of this study reveal that EPO might play a role as a survival factor or as a mitogen in developing cartilage tissue. Moreover, the presence of both proteins at the same locations supports the hypothesis that EPO expression is regulated by HIF-2 alpha.
Keywords
Chondrogenesis, HIF-2a, Hypoxia inducible factors, Erythropoietin, Cartilage, EXPRESSION PATTERNS, SPINAL-CORD, HYPOXIA, GROWTH, CHONDROGENESIS, CHONDROCYTES, PROPAGATION, HIF-1-ALPHA, RECEPTOR, DISEASE

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Citation

Please use this url to cite or link to this publication:

MLA
De Spiegelaere, Ward, Pieter Cornillie, and Wim Van Den Broeck. “Localization of Erythropoietin in and Around Growing Cartilage.” MOLECULAR AND CELLULAR BIOCHEMISTRY 337.1-2 (2010): 287–291. Print.
APA
De Spiegelaere, W., Cornillie, P., & Van Den Broeck, W. (2010). Localization of erythropoietin in and around growing cartilage. MOLECULAR AND CELLULAR BIOCHEMISTRY, 337(1-2), 287–291.
Chicago author-date
De Spiegelaere, Ward, Pieter Cornillie, and Wim Van Den Broeck. 2010. “Localization of Erythropoietin in and Around Growing Cartilage.” Molecular and Cellular Biochemistry 337 (1-2): 287–291.
Chicago author-date (all authors)
De Spiegelaere, Ward, Pieter Cornillie, and Wim Van Den Broeck. 2010. “Localization of Erythropoietin in and Around Growing Cartilage.” Molecular and Cellular Biochemistry 337 (1-2): 287–291.
Vancouver
1.
De Spiegelaere W, Cornillie P, Van Den Broeck W. Localization of erythropoietin in and around growing cartilage. MOLECULAR AND CELLULAR BIOCHEMISTRY. 2010;337(1-2):287–91.
IEEE
[1]
W. De Spiegelaere, P. Cornillie, and W. Van Den Broeck, “Localization of erythropoietin in and around growing cartilage,” MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 337, no. 1–2, pp. 287–291, 2010.
@article{979320,
  abstract     = {Erythropoietin (EPO) is known to be a hematopoietic growth factor and a regulator of red blood cell production. Recently, EPO has also been reported to function as a tissue-protective cytokine and as an angiogenesis promoting factor. EPO is mainly regulated by hypoxia through the action of hypoxia inducible factors (HIF-1 alpha and HIF-2 alpha). The localization of the EPO protein and the HIF-2 alpha protein were immunohistochemically analyzed in developing porcine embryos. Both proteins were localized in developing cartilage tissue. HIF-2 alpha and EPO protein were expressed in the peripheral chondrocytes of cartilage anlagen, in the perichondrium and in the cell condensations that will eventually differentiate into cartilage tissue. The results of this study reveal that EPO might play a role as a survival factor or as a mitogen in developing cartilage tissue. Moreover, the presence of both proteins at the same locations supports the hypothesis that EPO expression is regulated by HIF-2 alpha.},
  author       = {De Spiegelaere, Ward and Cornillie, Pieter and Van Den Broeck, Wim},
  issn         = {0300-8177},
  journal      = {MOLECULAR AND CELLULAR BIOCHEMISTRY},
  keywords     = {Chondrogenesis,HIF-2a,Hypoxia inducible factors,Erythropoietin,Cartilage,EXPRESSION PATTERNS,SPINAL-CORD,HYPOXIA,GROWTH,CHONDROGENESIS,CHONDROCYTES,PROPAGATION,HIF-1-ALPHA,RECEPTOR,DISEASE},
  language     = {eng},
  number       = {1-2},
  pages        = {287--291},
  title        = {Localization of erythropoietin in and around growing cartilage},
  url          = {http://dx.doi.org/10.1007/s11010-009-0310-3},
  volume       = {337},
  year         = {2010},
}

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