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Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens

Sandra De Boever (UGent) , Eva Neirinckx (UGent) , Evelyne Meyer (UGent) , Siegrid De Baere (UGent) , Rudi Beyaert (UGent) , Patrick De Backer (UGent) and Siska Croubels (UGent)
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Abstract
The pharmacodynamic properties of tepoxalin, Na-salicylate and ketoprofen were determined in an intravenous lipopolysaccharide (LPS) inflammation model in broiler chickens. The drugs were administered orally at a dose of 30, 50 and 3 mg/kg, respectively. LPS administration induces an increase in the intracellular expression of interleukin (IL)-1 beta and IL-6 and the secreted IL-6 plasma concentration. Furthermore, an elevation in body temperature is noted. Despite pretreatment with a single dose of the drugs and LPS administration on the T-max of the drug after a second dose, no decrease was seen in systemic IL-6 levels. The intracellular expression of IL-1 beta in the heterophils was slightly decreased if LPS was administered in combination with each of the three drugs. Tepoxalin and Na-salicylate administration had no significant effect on the LPS-induced increase in prostaglandin E-2 plasma concentration, in contrast to ketoprofen. None of the three drugs were able to influence the elevation in body temperature after LPS administration. The pharmacokinetic properties of Na-salicylate and ketoprofen were not altered in combination with LPS administration. However, LPS significantly decreased the AUC(0 -> 6 h) of the active metabolite of tepoxalin, RWJ-20142, indicating a perfusion-limited elimination for this molecule.
Keywords
inflammation model, pharmacology, PHARMACOLOGY, 5-LIPOXYGENASE, CYTOKINES, INHIBITORS, CYCLOOXYGENASE, PHARMACOKINETICS, FEVER, PROSTAGLANDIN E-2, KAPPA-B, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, chicken

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Chicago
De Boever, Sandra, Eva Neirinckx, Evelyne Meyer, Siegrid De Baere, Rudi Beyaert, Patrick De Backer, and Siska Croubels. 2010. “Pharmacodynamics of Tepoxalin, Sodium-salicylate and Ketoprofen in an Intravenous Lipopolysaccharide Inflammation Model in Broiler Chickens.” Journal of Veterinary Pharmacology and Therapeutics 33 (6): 564–572.
APA
De Boever, S., Neirinckx, E., Meyer, E., De Baere, S., Beyaert, R., De Backer, P., & Croubels, S. (2010). Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 33(6), 564–572.
Vancouver
1.
De Boever S, Neirinckx E, Meyer E, De Baere S, Beyaert R, De Backer P, et al. Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. 2010;33(6):564–72.
MLA
De Boever, Sandra, Eva Neirinckx, Evelyne Meyer, et al. “Pharmacodynamics of Tepoxalin, Sodium-salicylate and Ketoprofen in an Intravenous Lipopolysaccharide Inflammation Model in Broiler Chickens.” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 33.6 (2010): 564–572. Print.
@article{977517,
  abstract     = {The pharmacodynamic properties of tepoxalin, Na-salicylate and ketoprofen were determined in an intravenous lipopolysaccharide (LPS) inflammation model in broiler chickens. The drugs were administered orally at a dose of 30, 50 and 3 mg/kg, respectively. LPS administration induces an increase in the intracellular expression of interleukin (IL)-1 beta and IL-6 and the secreted IL-6 plasma concentration. Furthermore, an elevation in body temperature is noted. Despite pretreatment with a single dose of the drugs and LPS administration on the T-max of the drug after a second dose, no decrease was seen in systemic IL-6 levels. The intracellular expression of IL-1 beta in the heterophils was slightly decreased if LPS was administered in combination with each of the three drugs. Tepoxalin and Na-salicylate administration had no significant effect on the LPS-induced increase in prostaglandin E-2 plasma concentration, in contrast to ketoprofen. None of the three drugs were able to influence the elevation in body temperature after LPS administration. The pharmacokinetic properties of Na-salicylate and ketoprofen were not altered in combination with LPS administration. However, LPS significantly decreased the AUC(0 -{\textrangle} 6 h) of the active metabolite of tepoxalin, RWJ-20142, indicating a perfusion-limited elimination for this molecule.},
  author       = {De Boever, Sandra and Neirinckx, Eva and Meyer, Evelyne and De Baere, Siegrid and Beyaert, Rudi and De Backer, Patrick and Croubels, Siska},
  issn         = {0140-7783},
  journal      = {JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS},
  keyword      = {inflammation model,pharmacology,PHARMACOLOGY,5-LIPOXYGENASE,CYTOKINES,INHIBITORS,CYCLOOXYGENASE,PHARMACOKINETICS,FEVER,PROSTAGLANDIN E-2,KAPPA-B,NONSTEROIDAL ANTIINFLAMMATORY DRUGS,chicken},
  language     = {eng},
  number       = {6},
  pages        = {564--572},
  title        = {Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens},
  url          = {http://dx.doi.org/10.1111/j.1365-2885.2010.01184.x},
  volume       = {33},
  year         = {2010},
}

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