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Identification of the nasal mucosa as a new target for leptin action

Jasmien Taildeman UGent, Pieter Demetter, Isabelle Rottiers UGent, Gabriële Holtappels UGent, Claus Bachert UGent, Claude Cuvelier UGent and Claudina Perez Novo UGent (2010) HISTOPATHOLOGY. 56(6). p.789-798
abstract
Aims: Leptin is a key molecule in the regulation of energy homeostasis. Furthermore, several studies indicate that leptin also plays a pivotal role in immune and inflammatory responses. The aim of this study was to examine systemic and local nasal leptin and leptin receptor expression in patients with nasal polyposis and healthy controls. Methods and results: Serum leptin and soluble leptin receptor levels were examined by enzyme-linked immunosorbent assay (ELISA). The presence of leptin and leptin receptor mRNA was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR), and tissue leptin and leptin receptor protein expression was analysed by immunohistochemistry and ELISA. Serum levels of biologically active leptin were significantly elevated in patients with nasal polyps compared with control subjects. These serum leptin levels were strongly correlated with the levels found in tissue in both study groups, although leptin was not significantly elevated in nasal polyp tissue. Using RT-PCR, we showed that both leptin and its receptors were produced in nasal mucosa. Finally, immunohistochemistry showed that leptin and leptin receptor protein were expressed in several cells of the normal and inflamed nasal mucosa. Conclusions: Leptin receptors and their biological ligand leptin are expressed in the nasal mucosa, suggesting a possible role in upper airway immunology.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
leptin, nasal polyps, leptin receptor
journal title
HISTOPATHOLOGY
volume
56
issue
6
pages
789 - 798
publisher
WILEY-BLACKWELL PUBLISHING, INC, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
place of publication
USA
Web of Science type
article
Web of Science id
000277166300013
JCR category
PATHOLOGY
JCR impact factor
3.569 (2010)
JCR rank
15/75 (2010)
JCR quartile
1 (2010)
ISSN
0309-0167
DOI
10.1111/j.1365-2559.2010.03552.x
language
English
UGent publication?
yes
classification
A1
id
976813
handle
http://hdl.handle.net/1854/LU-976813
date created
2010-06-11 09:52:54
date last changed
2010-06-23 12:04:39
@article{976813,
  abstract     = {Aims:
Leptin is a key molecule in the regulation of energy homeostasis. Furthermore, several studies indicate that leptin also plays a pivotal role in immune and inflammatory responses. The aim of this study was to examine systemic and local nasal leptin and leptin receptor expression in patients with nasal polyposis and healthy controls.

Methods and results:

Serum leptin and soluble leptin receptor levels were examined by enzyme-linked immunosorbent assay (ELISA). The presence of leptin and leptin receptor mRNA was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR), and tissue leptin and leptin receptor protein expression was analysed by immunohistochemistry and ELISA.

Serum levels of biologically active leptin were significantly elevated in patients with nasal polyps compared with control subjects. These serum leptin levels were strongly correlated with the levels found in tissue in both study groups, although leptin was not significantly elevated in nasal polyp tissue. Using RT-PCR, we showed that both leptin and its receptors were produced in nasal mucosa. Finally, immunohistochemistry showed that leptin and leptin receptor protein were expressed in several cells of the normal and inflamed nasal mucosa.

Conclusions:

Leptin receptors and their biological ligand leptin are expressed in the nasal mucosa, suggesting a possible role in upper airway immunology.},
  author       = {Taildeman, Jasmien and Demetter, Pieter and Rottiers, Isabelle and Holtappels, Gabri{\"e}le and Bachert, Claus and Cuvelier, Claude and Perez Novo, Claudina},
  issn         = {0309-0167},
  journal      = {HISTOPATHOLOGY},
  keyword      = {leptin,nasal polyps,leptin receptor},
  language     = {eng},
  number       = {6},
  pages        = {789--798},
  publisher    = {WILEY-BLACKWELL PUBLISHING, INC, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA},
  title        = {Identification of the nasal mucosa as a new target for leptin action},
  url          = {http://dx.doi.org/10.1111/j.1365-2559.2010.03552.x},
  volume       = {56},
  year         = {2010},
}

Chicago
Taildeman, Jasmien, Pieter Demetter, ISABELLE ROTTIERS, Gabriële Holtappels, Claus Bachert, Claude Cuvelier, and Claudina Perez Novo. 2010. “Identification of the Nasal Mucosa as a New Target for Leptin Action.” Histopathology 56 (6): 789–798.
APA
Taildeman, J., Demetter, P., ROTTIERS, I., Holtappels, G., Bachert, C., Cuvelier, C., & Perez Novo, C. (2010). Identification of the nasal mucosa as a new target for leptin action. HISTOPATHOLOGY, 56(6), 789–798.
Vancouver
1.
Taildeman J, Demetter P, ROTTIERS I, Holtappels G, Bachert C, Cuvelier C, et al. Identification of the nasal mucosa as a new target for leptin action. HISTOPATHOLOGY. USA: WILEY-BLACKWELL PUBLISHING, INC, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA; 2010;56(6):789–98.
MLA
Taildeman, Jasmien, Pieter Demetter, ISABELLE ROTTIERS, et al. “Identification of the Nasal Mucosa as a New Target for Leptin Action.” HISTOPATHOLOGY 56.6 (2010): 789–798. Print.