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Assessing arterial distensibility using ultrasound wall-tracking diameter distension: an urgent need for direct stiffness measurement!

Patrick Segers UGent, Abigaïl Swillens UGent, Thomas De Schryver UGent, SEBASTIAN VERMEERSCH UGent, Ernst Rietzschel UGent and Marc De Buyzere UGent (2009) 2009 IEEE International Ultrasonics Symposium. p.2460-2463
abstract
Background: Arterial stiffness is increasingly used as an early marker of atherosclerosis and for the individual's assessment of cardiovascular risk. Ultrasound wall tracking allows assessing the distensibility coefficient DC = (ΔD/D)/ΔP with D diastolic diameter, ΔD cyclic diameter change and ΔP the local pulse pressure. Although DC depends on intrinsic stiffness, it also depends on vessel geometry. In this study, we reconcile DC of the common carotid artery measured within the framework of the Asklepios population study. Methods: Diameter, intimamedia thickness (IMT) and DC of the left common carotid artery were assessed in 2315 (1191women) apparently healthy subjects (age 35-56), using vascular ultrasound (Vivid 7, 12L probe) and wall tracking (media-adventitia transition) techniques. Evolution of DC and IMT/D with age was evaluated within the context of a theoretical framework linking DC, IMT/D and the Young elasticity modulus E [DC =1/(2.E.IMT/D)]. Results DC was higher in women than in men for age (35-40), while the inverse was true at age (51-56), suggesting a more rapid increase in stiffness in women. This evolution in DC is partly explained by arterial remodelling (increase in IMT/D) accompanied by an increase in intrinsic stiffness. While DC decreases by >30%, our data suggest an increase in intrinsic stiffness of about 25% over the studied age range. Conclusions: Clinically used measures of arterial stiffness are intrinsically dependent on arterial geometry. Direct measurements of stiffness are highly needed to avoid the ambiguity between an artery's kinematic behavior and its intrinsic mechanical properties.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
biomedical measurement, biomechanics, biomedical ultrasonics, blood vessels, cardiovascular system, diameter measurement, elastic constants, elasticity, physiological models, Young's modulus
in
2009 IEEE International Ultrasonics Symposium
pages
2460 - 2463
publisher
IEEE
place of publication
Piscataway, NJ, USA
conference name
2009 IEEE International Ultrasonics Symposium
conference location
Rome, Italy
conference start
2009-09-19
conference end
2009-09-23
Web of Science type
Conference Paper
Web of Science id
11221144
ISBN
9781424443895
9781424443901
DOI
10.1109/ULTSYM.2009.0610
language
English
UGent publication?
yes
classification
C1
copyright statement
I have transferred the copyright for this publication to the publisher
id
974371
handle
http://hdl.handle.net/1854/LU-974371
date created
2010-06-08 17:07:30
date last changed
2010-07-12 12:24:25
@inproceedings{974371,
  abstract     = {Background: Arterial stiffness is increasingly used as an early marker of atherosclerosis and for the individual's assessment of cardiovascular risk. Ultrasound wall tracking allows assessing the distensibility coefficient DC = (\ensuremath{\Delta}D/D)/\ensuremath{\Delta}P with D diastolic diameter, \ensuremath{\Delta}D cyclic diameter change and \ensuremath{\Delta}P the local pulse pressure. Although DC depends on intrinsic stiffness, it also depends on vessel geometry. In this study, we reconcile DC of the common carotid artery measured within the framework of the Asklepios population study.
Methods: Diameter, intimamedia thickness (IMT) and DC of the left common carotid artery were assessed in 2315 (1191women) apparently healthy subjects (age 35-56), using vascular ultrasound (Vivid 7, 12L probe) and wall tracking (media-adventitia transition) techniques. Evolution of DC and IMT/D with age was evaluated within the context of a theoretical framework linking DC, IMT/D and the Young elasticity modulus E [DC =1/(2.E.IMT/D)]. Results DC was higher in women than in men for age (35-40), while the inverse was true at age (51-56), suggesting a more rapid increase in stiffness in women. This evolution in DC is partly explained by arterial remodelling (increase in IMT/D) accompanied by an increase in intrinsic stiffness. While DC decreases by {\textrangle}30\%, our data suggest an increase in intrinsic stiffness of about 25\% over the studied age range. Conclusions: Clinically used measures of arterial stiffness are intrinsically dependent on arterial geometry. Direct measurements of stiffness are highly needed to avoid the ambiguity between an artery's kinematic behavior and its intrinsic mechanical properties.},
  author       = {Segers, Patrick and Swillens, Abiga{\"i}l and De Schryver, Thomas and VERMEERSCH, SEBASTIAN and Rietzschel, Ernst and De Buyzere, Marc},
  booktitle    = {2009 IEEE International Ultrasonics Symposium},
  isbn         = {9781424443895},
  keyword      = {biomedical measurement,biomechanics,biomedical ultrasonics,blood vessels,cardiovascular system,diameter measurement,elastic constants,elasticity,physiological models,Young's modulus},
  language     = {eng},
  location     = {Rome, Italy},
  pages        = {2460--2463},
  publisher    = {IEEE},
  title        = {Assessing arterial distensibility using ultrasound wall-tracking diameter distension: an urgent need for direct stiffness measurement!},
  url          = {http://dx.doi.org/10.1109/ULTSYM.2009.0610},
  year         = {2009},
}

Chicago
Segers, Patrick, Abigaïl Swillens, Thomas De Schryver, SEBASTIAN VERMEERSCH, Ernst Rietzschel, and Marc De Buyzere. 2009. “Assessing Arterial Distensibility Using Ultrasound Wall-tracking Diameter Distension: An Urgent Need for Direct Stiffness Measurement!” In 2009 IEEE International Ultrasonics Symposium, 2460–2463. Piscataway, NJ, USA: IEEE.
APA
Segers, Patrick, Swillens, A., De Schryver, T., VERMEERSCH, S., Rietzschel, E., & De Buyzere, M. (2009). Assessing arterial distensibility using ultrasound wall-tracking diameter distension: an urgent need for direct stiffness measurement! 2009 IEEE International Ultrasonics Symposium (pp. 2460–2463). Presented at the 2009 IEEE International Ultrasonics Symposium, Piscataway, NJ, USA: IEEE.
Vancouver
1.
Segers P, Swillens A, De Schryver T, VERMEERSCH S, Rietzschel E, De Buyzere M. Assessing arterial distensibility using ultrasound wall-tracking diameter distension: an urgent need for direct stiffness measurement! 2009 IEEE International Ultrasonics Symposium. Piscataway, NJ, USA: IEEE; 2009. p. 2460–3.
MLA
Segers, Patrick, Abigaïl Swillens, Thomas De Schryver, et al. “Assessing Arterial Distensibility Using Ultrasound Wall-tracking Diameter Distension: An Urgent Need for Direct Stiffness Measurement!” 2009 IEEE International Ultrasonics Symposium. Piscataway, NJ, USA: IEEE, 2009. 2460–2463. Print.