Ghent University Academic Bibliography

Advanced

A novel simulation strategy for stent insertion and deployment in curved coronary bifurcations: comparison of three drug-eluting stents

Peter Mortier UGent, Gerhard A Holzapfel, Matthieu De Beule UGent, Denis Van Loo UGent, Yvo Taeymans UGent, Patrick Segers UGent, Pascal Verdonck UGent and Benedict Verhegghe UGent (2010) ANNALS OF BIOMEDICAL ENGINEERING. 38(1). p.88-99
abstract
The introduction of drug-eluting stents (DES) has reduced the occurrence of restenosis in coronary arteries. However, restenosis remains a problem in stented coronary bifurcations. This study investigates and compares three different second generation DESs when being implanted in the curved main branch of a coronary bifurcation with the aim of providing better insights into the related changes of the mechanical environment. The 3D bifurcation model is based on patient-specific angiographic data that accurately reproduce the in vivo curvatures of the vessel segments. The layered structure of the arterial wall and its anisotropic mechanical behavior are taken into account by applying a novel algorithm to define the fiber orientations. An innovative simulation strategy considering the insertion of a folded balloon catheter over a guide wire is proposed in order to position the stents within the curved vessel. Straightening occurs after implantation of all stents investigated. The resulting distributions of the wall stresses are strongly dependent on the stent design. Using a parametric modeling approach, two design modifications, which reduce the predicted maximum values of the wall stress, are proposed and analyzed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
finite element anlaysis, insertion, patient-specific bifurcation model, FINITE-ELEMENT-ANALYSIS, drug-eluting stents, ARTERIES, BEHAVIOR, DESIGNS, VESSEL, MODEL, VIVO
journal title
ANNALS OF BIOMEDICAL ENGINEERING
Ann. Biomed. Eng.
volume
38
issue
1
pages
88 - 99
Web of Science type
Article
Web of Science id
000273445000008
JCR category
ENGINEERING, BIOMEDICAL
JCR impact factor
2.374 (2010)
JCR rank
19/68 (2010)
JCR quartile
2 (2010)
ISSN
0090-6964
DOI
10.1007/s10439-009-9836-5
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
973459
handle
http://hdl.handle.net/1854/LU-973459
date created
2010-06-08 14:40:53
date last changed
2010-06-30 11:44:04
@article{973459,
  abstract     = {The introduction of drug-eluting stents (DES) has reduced the occurrence of restenosis in coronary arteries. However, restenosis remains a problem in stented coronary bifurcations. This study investigates and compares three different second generation DESs when being implanted in the curved main branch of a coronary bifurcation with the aim of providing better insights into the related changes of the mechanical environment. The 3D bifurcation model is based on patient-specific angiographic data that accurately reproduce the in vivo curvatures of the vessel segments. The layered structure of the arterial wall and its anisotropic mechanical behavior are taken into account by applying a novel algorithm to define the fiber orientations. An innovative simulation strategy considering the insertion of a folded balloon catheter over a guide wire is proposed in order to position the stents within the curved vessel. Straightening occurs after implantation of all stents investigated. The resulting distributions of the wall stresses are strongly dependent on the stent design. Using a parametric modeling approach, two design modifications, which reduce the predicted maximum values of the wall stress, are proposed and analyzed.},
  author       = {Mortier, Peter and Holzapfel, Gerhard A and De Beule, Matthieu and Van Loo, Denis and Taeymans, Yvo and Segers, Patrick and Verdonck, Pascal and Verhegghe, Benedict},
  issn         = {0090-6964},
  journal      = {ANNALS OF BIOMEDICAL ENGINEERING},
  keyword      = {finite element anlaysis,insertion,patient-specific bifurcation model,FINITE-ELEMENT-ANALYSIS,drug-eluting stents,ARTERIES,BEHAVIOR,DESIGNS,VESSEL,MODEL,VIVO},
  language     = {eng},
  number       = {1},
  pages        = {88--99},
  title        = {A novel simulation strategy for stent insertion and deployment in curved coronary bifurcations: comparison of three drug-eluting stents},
  url          = {http://dx.doi.org/10.1007/s10439-009-9836-5},
  volume       = {38},
  year         = {2010},
}

Chicago
Mortier, Peter, Gerhard A Holzapfel, Matthieu De Beule, Denis Van Loo, Yvo Taeymans, Patrick Segers, Pascal Verdonck, and Benedict Verhegghe. 2010. “A Novel Simulation Strategy for Stent Insertion and Deployment in Curved Coronary Bifurcations: Comparison of Three Drug-eluting Stents.” Annals of Biomedical Engineering 38 (1): 88–99.
APA
Mortier, P., Holzapfel, G. A., De Beule, M., Van Loo, D., Taeymans, Y., Segers, P., Verdonck, P., et al. (2010). A novel simulation strategy for stent insertion and deployment in curved coronary bifurcations: comparison of three drug-eluting stents. ANNALS OF BIOMEDICAL ENGINEERING, 38(1), 88–99.
Vancouver
1.
Mortier P, Holzapfel GA, De Beule M, Van Loo D, Taeymans Y, Segers P, et al. A novel simulation strategy for stent insertion and deployment in curved coronary bifurcations: comparison of three drug-eluting stents. ANNALS OF BIOMEDICAL ENGINEERING. 2010;38(1):88–99.
MLA
Mortier, Peter, Gerhard A Holzapfel, Matthieu De Beule, et al. “A Novel Simulation Strategy for Stent Insertion and Deployment in Curved Coronary Bifurcations: Comparison of Three Drug-eluting Stents.” ANNALS OF BIOMEDICAL ENGINEERING 38.1 (2010): 88–99. Print.