Advanced search
1 file | 303.31 KB Add to list

Mathematical model of the acute inflammatory response to Escherichia coli in intramammary challenge

(2006) JOURNAL OF DAIRY SCIENCE. 89(9). p.3455-3465
Author
Organization
Abstract
We constructed a mathematical model of the early response to Escherichia coli infection of the mammary gland and explored the roles and interactions between inflammatory cells and bacteria. The model incorporates 3 equations that describe the interactions among bacteria, milk somatic cells, and blood leukocyte densities. These 3 equations were fitted to cell densities observed during acute inflammatory responses in unvaccinated and vaccinated heifers inoculated with 10(4) or 10(6) cfu of E. coli. The rates computed for the cellular transit from the storage sites to the blood and from the blood to the milk were lower in cows receiving 10(4) cfu but increased at approximately 6 x 10(-6) and 30 x 10(-6) mu L/cfu per h in nonvaccinated or vaccinated cows inoculated with 10(6) cfu, respectively. The cellular rates of bacterial killing were highest in unvaccinated cows (similar to 400 x 10(-6) mu L/cell per h) when compared with vaccinated cows (200 to 300 x 10(-6) mu L/cell per h). A critical density of milk somatic cells at which bacteria density is constant was computed from the model at 2 x 10(6) cells/mL, and a one-way sensitivity analysis revealed that the changes in milk cellular densities were mostly sensitive to variations in the rate of bacterial killing and in the rate of production of inflammatory cells.
Keywords
DAIRY-COWS, BACTERICIDAL ACTIVITY, SOMATIC-CELL COUNT, POLYMORPHONUCLEAR LEUKOCYTES, BOVINE MAMMARY-GLAND, STAPHYLOCOCCUS-AUREUS, NEUTROPHIL APOPTOSIS, IN-VITRO, PRIMIPAROUS COWS, VIRULENCE FACTORS

Downloads

  • Detilleux et al. - JDS - 2006.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 303.31 KB

Citation

Please use this url to cite or link to this publication:

MLA
Detilleux, J., et al. “Mathematical Model of the Acute Inflammatory Response to Escherichia Coli in Intramammary Challenge.” JOURNAL OF DAIRY SCIENCE, vol. 89, no. 9, 2006, pp. 3455–65.
APA
Detilleux, J., Vangroenweghe, F., & Burvenich, C. (2006). Mathematical model of the acute inflammatory response to Escherichia coli in intramammary challenge. JOURNAL OF DAIRY SCIENCE, 89(9), 3455–3465.
Chicago author-date
Detilleux, J, Frédéric Vangroenweghe, and Christian Burvenich. 2006. “Mathematical Model of the Acute Inflammatory Response to Escherichia Coli in Intramammary Challenge.” JOURNAL OF DAIRY SCIENCE 89 (9): 3455–65.
Chicago author-date (all authors)
Detilleux, J, Frédéric Vangroenweghe, and Christian Burvenich. 2006. “Mathematical Model of the Acute Inflammatory Response to Escherichia Coli in Intramammary Challenge.” JOURNAL OF DAIRY SCIENCE 89 (9): 3455–3465.
Vancouver
1.
Detilleux J, Vangroenweghe F, Burvenich C. Mathematical model of the acute inflammatory response to Escherichia coli in intramammary challenge. JOURNAL OF DAIRY SCIENCE. 2006;89(9):3455–65.
IEEE
[1]
J. Detilleux, F. Vangroenweghe, and C. Burvenich, “Mathematical model of the acute inflammatory response to Escherichia coli in intramammary challenge,” JOURNAL OF DAIRY SCIENCE, vol. 89, no. 9, pp. 3455–3465, 2006.
@article{971822,
  abstract     = {{We constructed a mathematical model of the early response to Escherichia coli infection of the mammary gland and explored the roles and interactions between inflammatory cells and bacteria. The model incorporates 3 equations that describe the interactions among bacteria, milk somatic cells, and blood leukocyte densities. These 3 equations were fitted to cell densities observed during acute inflammatory responses in unvaccinated and vaccinated heifers inoculated with 10(4) or 10(6) cfu of E. coli. The rates computed for the cellular transit from the storage sites to the blood and from the blood to the milk were lower in cows receiving 10(4) cfu but increased at approximately 6 x 10(-6) and 30 x 10(-6) mu L/cfu per h in nonvaccinated or vaccinated cows inoculated with 10(6) cfu, respectively. The cellular rates of bacterial killing were highest in unvaccinated cows (similar to 400 x 10(-6) mu L/cell per h) when compared with vaccinated cows (200 to 300 x 10(-6) mu L/cell per h). A critical density of milk somatic cells at which bacteria density is constant was computed from the model at 2 x 10(6) cells/mL, and a one-way sensitivity analysis revealed that the changes in milk cellular densities were mostly sensitive to variations in the rate of bacterial killing and in the rate of production of inflammatory cells.}},
  author       = {{Detilleux, J and Vangroenweghe, Frédéric and Burvenich, Christian}},
  issn         = {{0022-0302}},
  journal      = {{JOURNAL OF DAIRY SCIENCE}},
  keywords     = {{DAIRY-COWS,BACTERICIDAL ACTIVITY,SOMATIC-CELL COUNT,POLYMORPHONUCLEAR LEUKOCYTES,BOVINE MAMMARY-GLAND,STAPHYLOCOCCUS-AUREUS,NEUTROPHIL APOPTOSIS,IN-VITRO,PRIMIPAROUS COWS,VIRULENCE FACTORS}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{3455--3465}},
  title        = {{Mathematical model of the acute inflammatory response to Escherichia coli in intramammary challenge}},
  volume       = {{89}},
  year         = {{2006}},
}

Web of Science
Times cited: