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Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore : the domestic cat (Felis catus)

Adronie Verbrugghe (UGent) , Geert Janssens (UGent) , Eva Meininger (UGent) , Sylvie Daminet (UGent) , Koen Piron (UGent) , Lynn Vanhaecke (UGent) , Brigitte Wuyts (UGent) , Johan Buyse and Myriam Hesta (UGent)
(2010) BRITISH JOURNAL OF NUTRITION. 104(7). p.972-979
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Abstract
N balance and postprandial acylcarnitine profile following intestinal fermentation of oligofructose and inulin were investigated in healthy cats. Two diets were tested in a crossover design: a commercial high-protein cat food supplemented with 4% DM oligofructose and inulin (spectrum: degree of polymerisation (DP) 2-10: 60 (SE 5)% DM; DP > 10: 28 (SE 5)% DM) as high-fermentable fibre (HFF) diet, and the same commercial diet supplemented with 4% DM cellulose as low-fermentable fibre diet. Eight adult cats were randomly allotted to each of the two diets at intervals of 4 weeks. At the end of each testing period, faeces and urine were collected over a 5-d period, and blood samples were obtained before and at the selected time points postprandially. No differences were found for N intake, N digestibility and faecal N excretion, whereas urinary N excretion was lower when the HFF diet was fed (P=0.044). N balance was positive in all the cats, and tended to be increased when the HFF diet was fed (P=0.079). Propionylcarnitine concentrations (P=0.015) and their area under the curve (AUC) (P=0.013) were increased when the HFF diet was fed, revealing a more pronounced production and absorption of propionate. Yet, methylmalonylcarnitine concentrations and concurrent AUC were not elevated when the HFF diet was fed, indicating reduced amino acid catabolism. 3-Hydroxy-3-methylglutarylcarnitine concentrations (P=0.026) and their AUC (P=0.028) were also reduced when the HFF diet was fed, implying diminished use of branched-chain amino acids as well. In healthy cats, oligofructose and inulin added to a high-protein diet were suggested to reduce postprandial amino acid-induced gluconeogenesis by substitution with propionate.
Keywords
Dietary fibre, Carnivore, Gluconeogenesis, Propionate, Acylcarnitine, IN-VITRO FERMENTATION, BACTERIAL-FLORA, DIETARY FIBER, HEALTHY CATS, NUTRIENT DIGESTIBILITY, GLUCOSE-METABOLISM, FECAL INOCULUM, OLIGOFRUCTOSE, DOGS, INULIN

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Chicago
Verbrugghe, Adronie, Geert Janssens, Eva Meininger, Sylvie Daminet, Koen Piron, Lynn Vanhaecke, Brigitte Wuyts, Johan Buyse, and Myriam Hesta. 2010. “Intestinal Fermentation Modulates Postprandial Acylcarnitine Profile and Nitrogen Metabolism in a True Carnivore : the Domestic Cat (Felis Catus).” British Journal of Nutrition 104 (7): 972–979.
APA
Verbrugghe, A., Janssens, G., Meininger, E., Daminet, S., Piron, K., Vanhaecke, L., Wuyts, B., et al. (2010). Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore : the domestic cat (Felis catus). BRITISH JOURNAL OF NUTRITION, 104(7), 972–979.
Vancouver
1.
Verbrugghe A, Janssens G, Meininger E, Daminet S, Piron K, Vanhaecke L, et al. Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore : the domestic cat (Felis catus). BRITISH JOURNAL OF NUTRITION. 2010;104(7):972–9.
MLA
Verbrugghe, Adronie, Geert Janssens, Eva Meininger, et al. “Intestinal Fermentation Modulates Postprandial Acylcarnitine Profile and Nitrogen Metabolism in a True Carnivore : the Domestic Cat (Felis Catus).” BRITISH JOURNAL OF NUTRITION 104.7 (2010): 972–979. Print.
@article{967663,
  abstract     = {N balance and postprandial acylcarnitine profile following intestinal fermentation of oligofructose and inulin were investigated in healthy cats. Two diets were tested in a crossover design: a commercial high-protein cat food supplemented with 4\% DM oligofructose and inulin (spectrum: degree of polymerisation (DP) 2-10: 60 (SE 5)\% DM; DP {\textrangle} 10: 28 (SE 5)\% DM) as high-fermentable fibre (HFF) diet, and the same commercial diet supplemented with 4\% DM cellulose as low-fermentable fibre diet. Eight adult cats were randomly allotted to each of the two diets at intervals of 4 weeks. At the end of each testing period, faeces and urine were collected over a 5-d period, and blood samples were obtained before and at the selected time points postprandially. No differences were found for N intake, N digestibility and faecal N excretion, whereas urinary N excretion was lower when the HFF diet was fed (P=0.044). N balance was positive in all the cats, and tended to be increased when the HFF diet was fed (P=0.079). Propionylcarnitine concentrations (P=0.015) and their area under the curve (AUC) (P=0.013) were increased when the HFF diet was fed, revealing a more pronounced production and absorption of propionate. Yet, methylmalonylcarnitine concentrations and concurrent AUC were not elevated when the HFF diet was fed, indicating reduced amino acid catabolism. 3-Hydroxy-3-methylglutarylcarnitine concentrations (P=0.026) and their AUC (P=0.028) were also reduced when the HFF diet was fed, implying diminished use of branched-chain amino acids as well. In healthy cats, oligofructose and inulin added to a high-protein diet were suggested to reduce postprandial amino acid-induced gluconeogenesis by substitution with propionate.},
  author       = {Verbrugghe, Adronie and Janssens, Geert and Meininger, Eva and Daminet, Sylvie and Piron, Koen and Vanhaecke, Lynn and Wuyts, Brigitte and Buyse, Johan and Hesta, Myriam},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  keyword      = {Dietary fibre,Carnivore,Gluconeogenesis,Propionate,Acylcarnitine,IN-VITRO FERMENTATION,BACTERIAL-FLORA,DIETARY FIBER,HEALTHY CATS,NUTRIENT DIGESTIBILITY,GLUCOSE-METABOLISM,FECAL INOCULUM,OLIGOFRUCTOSE,DOGS,INULIN},
  language     = {eng},
  number       = {7},
  pages        = {972--979},
  title        = {Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore : the domestic cat (Felis catus)},
  url          = {http://dx.doi.org/10.1017/S0007114510001558},
  volume       = {104},
  year         = {2010},
}

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