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Effect of Thyroxine Supplementation on Glomerular Filtration Rate in Hypothyroid Dogs

Kris Gommeren UGent, Ingrid van Hoek UGent, HP Lefebvre, G Benchekroun, Pascale Smets UGent and Sylvie Daminet UGent (2009) JOURNAL OF VETERINARY INTERNAL MEDICINE. 23(4). p.844-849
abstract
Background Glomerular filtration rate (GFR) is decreased in humans with hypothyroidism, but information about kidney function in dogs with hypothyroidism is lacking. Hypothesis Hypothyroidism influences GFR in dogs. The objective of this study was to assess GFR in hypothyroid dogs before implementation of thyroxine supplementation and after re-establishing euthyroidism. Animals Fourteen hypothyroid dogs without abnormalities on renal ultrasound examination or urinalysis. Methods Blood pressure and GFR (measured by exogenous creatinine clearance) were measured before treatment (T0, n = 14) and at 1 month (T1, n = 14) and at 6 months (T6, n = 11) after beginning levothyroxine supplementation therapy (20 mu g/kg/d, PO). The response to therapy was monitored at T1 by measuring serum total thyroxine and thyroid stimulating hormone concentrations. If needed, levothyroxine dosage was adjusted and reassessed after 1 month. Statistical analysis was performed using a general linear model. Results are expressed as mean +/- standard deviation. Results At T0, the average age of dogs in the study group was 6.3 +/- 1.4 years. Their average body weight decreased from 35 +/- 18 kg at T0 to 27 +/- 14 kg at T6 (P < .05). All dogs remained normotensive throughout the study. GFR increased significantly with levothyroxine supplementation; the corresponding results were 1.6 +/- 0.4 mL/min/kg at T0, 2.1 +/- 0.4 at T1, and 2.0 +/- 0.4 at T6 (P < .01). Conclusion GFR was < 2 mL/min/kg in untreated hypothyroid dogs. Re-establishment of a euthyroid state increased GFR significantly.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PLASMA-CLEARANCE, ENDO-IOHEXOL, THYROID-HORMONE, EXOGENOUS CREATININE, RENIN-ANGIOTENSIN SYSTEM, ACUTE-RENAL-FAILURE, Thyroid, Hypothyroidism, Kidney function, Canine, EXO-IOHEXOL, HEALTHY, DISEASE, SODIUM
journal title
JOURNAL OF VETERINARY INTERNAL MEDICINE
J. Vet. Intern. Med.
volume
23
issue
4
pages
6 pages
publisher
WILEY-BLACKWELL PUBLISHING, INC
place of publication
MALDEN
Web of Science type
Article
Web of Science id
000267427100010
JCR category
VETERINARY SCIENCES
JCR impact factor
2.168 (2009)
JCR rank
8/141 (2009)
JCR quartile
1 (2009)
ISSN
0891-6640
DOI
10.1111/j.1939-1676.2009.0331.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
966473
handle
http://hdl.handle.net/1854/LU-966473
date created
2010-05-31 13:27:41
date last changed
2010-06-17 09:40:18
@article{966473,
  abstract     = {Background
Glomerular filtration rate (GFR) is decreased in humans with hypothyroidism, but information about kidney function in dogs with hypothyroidism is lacking.

Hypothesis
Hypothyroidism influences GFR in dogs. The objective of this study was to assess GFR in hypothyroid dogs before implementation of thyroxine supplementation and after re-establishing euthyroidism.

Animals
Fourteen hypothyroid dogs without abnormalities on renal ultrasound examination or urinalysis.

Methods
Blood pressure and GFR (measured by exogenous creatinine clearance) were measured before treatment (T0, n = 14) and at 1 month (T1, n = 14) and at 6 months (T6, n = 11) after beginning levothyroxine supplementation therapy (20 mu g/kg/d, PO). The response to therapy was monitored at T1 by measuring serum total thyroxine and thyroid stimulating hormone concentrations. If needed, levothyroxine dosage was adjusted and reassessed after 1 month. Statistical analysis was performed using a general linear model. Results are expressed as mean +/- standard deviation.

Results
At T0, the average age of dogs in the study group was 6.3 +/- 1.4 years. Their average body weight decreased from 35 +/- 18 kg at T0 to 27 +/- 14 kg at T6 (P {\textlangle} .05). All dogs remained normotensive throughout the study. GFR increased significantly with levothyroxine supplementation; the corresponding results were 1.6 +/- 0.4 mL/min/kg at T0, 2.1 +/- 0.4 at T1, and 2.0 +/- 0.4 at T6 (P {\textlangle} .01).

Conclusion
GFR was {\textlangle} 2 mL/min/kg in untreated hypothyroid dogs. Re-establishment of a euthyroid state increased GFR significantly.},
  author       = {Gommeren, Kris and van Hoek, Ingrid and Lefebvre, HP and Benchekroun, G and Smets, Pascale and Daminet, Sylvie},
  issn         = {0891-6640},
  journal      = {JOURNAL OF VETERINARY INTERNAL MEDICINE},
  keyword      = {PLASMA-CLEARANCE,ENDO-IOHEXOL,THYROID-HORMONE,EXOGENOUS CREATININE,RENIN-ANGIOTENSIN SYSTEM,ACUTE-RENAL-FAILURE,Thyroid,Hypothyroidism,Kidney function,Canine,EXO-IOHEXOL,HEALTHY,DISEASE,SODIUM},
  language     = {eng},
  number       = {4},
  pages        = {844--849},
  publisher    = {WILEY-BLACKWELL PUBLISHING, INC},
  title        = {Effect of Thyroxine Supplementation on Glomerular Filtration Rate in Hypothyroid Dogs},
  url          = {http://dx.doi.org/10.1111/j.1939-1676.2009.0331.x},
  volume       = {23},
  year         = {2009},
}

Chicago
Gommeren, Kris, Ingrid van Hoek, HP Lefebvre, G Benchekroun, Pascale Smets, and Sylvie Daminet. 2009. “Effect of Thyroxine Supplementation on Glomerular Filtration Rate in Hypothyroid Dogs.” Journal of Veterinary Internal Medicine 23 (4): 844–849.
APA
Gommeren, K., van Hoek, I., Lefebvre, H., Benchekroun, G., Smets, P., & Daminet, S. (2009). Effect of Thyroxine Supplementation on Glomerular Filtration Rate in Hypothyroid Dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, 23(4), 844–849.
Vancouver
1.
Gommeren K, van Hoek I, Lefebvre H, Benchekroun G, Smets P, Daminet S. Effect of Thyroxine Supplementation on Glomerular Filtration Rate in Hypothyroid Dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE. MALDEN: WILEY-BLACKWELL PUBLISHING, INC; 2009;23(4):844–9.
MLA
Gommeren, Kris, Ingrid van Hoek, HP Lefebvre, et al. “Effect of Thyroxine Supplementation on Glomerular Filtration Rate in Hypothyroid Dogs.” JOURNAL OF VETERINARY INTERNAL MEDICINE 23.4 (2009): 844–849. Print.