Advanced search
1 file | 812.84 KB Add to list

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

Tom Vanden Berghe (UGent) , Nele Vanlangenakker (UGent) , Eef Parthoens (UGent) , Wies Deckers, Michael Devos (UGent) , Nele Festjens (UGent) , Chris Guerin (UGent) , UT Brunk, Wim Declercq (UGent) and Peter Vandenabeele (UGent)
(2010) CELL DEATH AND DIFFERENTIATION. 17(6). p.922-930
Author
Organization
Abstract
Necroptosis, necrosis and secondary necrosis following apoptosis represent different modes of cell death that eventually result in similar cellular morphology including rounding of the cell, cytoplasmic swelling, rupture of the plasma membrane and spilling of the intracellular content. Subcellular events during tumor necrosis factor (TNF)-induced necroptosis, H2O2-induced necrosis and anti-Fas-induced secondary necrosis were studied using high-resolution time-lapse microscopy. The cellular disintegration phase of the three types of necrosis is characterized by an identical sequence of subcellular events, including oxidative burst, mitochondrial membrane hyperpolarization, lysosomal membrane permeabilization and plasma membrane permeabilization, although with different kinetics. H2O2-induced necrosis starts immediately by lysosomal permeabilization. In contrast, during TNF-mediated necroptosis and anti-Fas-induced secondary necrosis, this is a late event preceded by a defined signaling phase. TNF-induced necroptosis depends on receptor-interacting protein-1 kinase, mitochondrial complex I and cytosolic phospholipase A(2) activities, whereas H2O2-induced necrosis requires iron-dependent Fenton reactions.
Keywords
MITOCHONDRIAL, CATHEPSIN-B, INHIBITION, INDUCTION, APOPTOSIS, OXIDATIVE-STRESS, lysosomes, Fenton reactions, RIP1, necrosis, time-lapse, DEATH PATHWAY, NADPH OXIDASE, INTRALYSOSOMAL IRON, RECEPTOR-INTERACTING PROTEIN

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 812.84 KB

Citation

Please use this url to cite or link to this publication:

MLA
Vanden Berghe, Tom et al. “Necroptosis, Necrosis and Secondary Necrosis Converge on Similar Cellular Disintegration Features.” CELL DEATH AND DIFFERENTIATION 17.6 (2010): 922–930. Print.
APA
Vanden Berghe, T., Vanlangenakker, N., Parthoens, E., Deckers, W., Devos, M., Festjens, N., Guerin, C., et al. (2010). Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. CELL DEATH AND DIFFERENTIATION, 17(6), 922–930.
Chicago author-date
Vanden Berghe, Tom, Nele Vanlangenakker, Eef Parthoens, Wies Deckers, Michael Devos, Nele Festjens, Chris Guerin, UT Brunk, Wim Declercq, and Peter Vandenabeele. 2010. “Necroptosis, Necrosis and Secondary Necrosis Converge on Similar Cellular Disintegration Features.” Cell Death and Differentiation 17 (6): 922–930.
Chicago author-date (all authors)
Vanden Berghe, Tom, Nele Vanlangenakker, Eef Parthoens, Wies Deckers, Michael Devos, Nele Festjens, Chris Guerin, UT Brunk, Wim Declercq, and Peter Vandenabeele. 2010. “Necroptosis, Necrosis and Secondary Necrosis Converge on Similar Cellular Disintegration Features.” Cell Death and Differentiation 17 (6): 922–930.
Vancouver
1.
Vanden Berghe T, Vanlangenakker N, Parthoens E, Deckers W, Devos M, Festjens N, et al. Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. CELL DEATH AND DIFFERENTIATION. 2010;17(6):922–30.
IEEE
[1]
T. Vanden Berghe et al., “Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features,” CELL DEATH AND DIFFERENTIATION, vol. 17, no. 6, pp. 922–930, 2010.
@article{958556,
  abstract     = {Necroptosis, necrosis and secondary necrosis following apoptosis represent different modes of cell death that eventually result in similar cellular morphology including rounding of the cell, cytoplasmic swelling, rupture of the plasma membrane and spilling of the intracellular content. Subcellular events during tumor necrosis factor (TNF)-induced necroptosis, H2O2-induced necrosis and anti-Fas-induced secondary necrosis were studied using high-resolution time-lapse microscopy. The cellular disintegration phase of the three types of necrosis is characterized by an identical sequence of subcellular events, including oxidative burst, mitochondrial membrane hyperpolarization, lysosomal membrane permeabilization and plasma membrane permeabilization, although with different kinetics. H2O2-induced necrosis starts immediately by lysosomal permeabilization. In contrast, during TNF-mediated necroptosis and anti-Fas-induced secondary necrosis, this is a late event preceded by a defined signaling phase. TNF-induced necroptosis depends on receptor-interacting protein-1 kinase, mitochondrial complex I and cytosolic phospholipase A(2) activities, whereas H2O2-induced necrosis requires iron-dependent Fenton reactions.},
  author       = {Vanden Berghe, Tom and Vanlangenakker, Nele and Parthoens, Eef and Deckers, Wies and Devos, Michael and Festjens, Nele and Guerin, Chris and Brunk, UT and Declercq, Wim and Vandenabeele, Peter},
  issn         = {1350-9047},
  journal      = {CELL DEATH AND DIFFERENTIATION},
  keywords     = {MITOCHONDRIAL,CATHEPSIN-B,INHIBITION,INDUCTION,APOPTOSIS,OXIDATIVE-STRESS,lysosomes,Fenton reactions,RIP1,necrosis,time-lapse,DEATH PATHWAY,NADPH OXIDASE,INTRALYSOSOMAL IRON,RECEPTOR-INTERACTING PROTEIN},
  language     = {eng},
  number       = {6},
  pages        = {922--930},
  title        = {Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features},
  url          = {http://dx.doi.org/10.1038/cdd.2009.184},
  volume       = {17},
  year         = {2010},
}

Altmetric
View in Altmetric
Web of Science
Times cited: