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Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths

(2010) GREEN CHEMISTRY. 12(4). p.666-671
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Abstract
In this paper, a novel resin-based crystallisation method was developed for the recovery of succinic acid (SA) crystals from fermentation broths (FB) using Actinobacillus succinogenes. Direct crystallisation of synthetic fermentation broths was firstly investigated and the results indicated that the synthetic fermentation broth consisting of a mixture of organic acids (in the free acid form rather than in the salt form) could significantly benefit in succinic acid recovery. Therefore, a commercially available cation-exchange resin Amberlite IR 120H was employed to convert the fermentation end-products such as succinate, formate, acetate and pyruvate from the salt form into the free acid form. Then, succinic acid was selectively separated from the acid mixture by vacuum evaporation and crystallisation. Highly purified SA crystals were successfully recovered from both synthetic and real fermentation broths using this method. A higher SA crystal purity (99%) and yield (89.5%) were obtained in the direct crystallisation method using an ion-exchange resin as compared to the direct acid addition method (46% and 35%, respectively). The work presented here sets the stage for the development of an efficient resin-based vacuum-distillation and crystallisation system for the recovery of succinic acid crystals from fermentation broths.
Keywords
TECHNOLOGY, STRAIN, BIOREFINING STRATEGY, ORGANIC-ACIDS, ESCHERICHIA-COLI, ACTINOBACILLUS-SUCCINOGENES, ADSORPTION, STATE, YIELD

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MLA
LIN, Carol Sze Ki et al. “Novel Resin-based Vacuum Distillation-crystallisation Method for Recovery of Succinic Acid Crystals from Fermentation Broths.” GREEN CHEMISTRY 12.4 (2010): 666–671. Print.
APA
LIN, C. S. K., Du, C., Blaga, A. C., Camarut, M., Webb, C., Stevens, C., & Soetaert, W. (2010). Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths. GREEN CHEMISTRY, 12(4), 666–671.
Chicago author-date
LIN, Carol Sze Ki, Chenyu Du, Alexandra Cristina Blaga, Maria Camarut, Colin Webb, Christian Stevens, and Wim Soetaert. 2010. “Novel Resin-based Vacuum Distillation-crystallisation Method for Recovery of Succinic Acid Crystals from Fermentation Broths.” Green Chemistry 12 (4): 666–671.
Chicago author-date (all authors)
LIN, Carol Sze Ki, Chenyu Du, Alexandra Cristina Blaga, Maria Camarut, Colin Webb, Christian Stevens, and Wim Soetaert. 2010. “Novel Resin-based Vacuum Distillation-crystallisation Method for Recovery of Succinic Acid Crystals from Fermentation Broths.” Green Chemistry 12 (4): 666–671.
Vancouver
1.
LIN CSK, Du C, Blaga AC, Camarut M, Webb C, Stevens C, et al. Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths. GREEN CHEMISTRY. 2010;12(4):666–71.
IEEE
[1]
C. S. K. LIN et al., “Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths,” GREEN CHEMISTRY, vol. 12, no. 4, pp. 666–671, 2010.
@article{956487,
  abstract     = {In this paper, a novel resin-based crystallisation method was developed for the recovery of succinic acid (SA) crystals from fermentation broths (FB) using Actinobacillus succinogenes. Direct crystallisation of synthetic fermentation broths was firstly investigated and the results indicated that the synthetic fermentation broth consisting of a mixture of organic acids (in the free acid form rather than in the salt form) could significantly benefit in succinic acid recovery. Therefore, a commercially available cation-exchange resin Amberlite IR 120H was employed to convert the fermentation end-products such as succinate, formate, acetate and pyruvate from the salt form into the free acid form. Then, succinic acid was selectively separated from the acid mixture by vacuum evaporation and crystallisation. Highly purified SA crystals were successfully recovered from both synthetic and real fermentation broths using this method. A higher SA crystal purity (99%) and yield (89.5%) were obtained in the direct crystallisation method using an ion-exchange resin as compared to the direct acid addition method (46% and 35%, respectively). The work presented here sets the stage for the development of an efficient resin-based vacuum-distillation and crystallisation system for the recovery of succinic acid crystals from fermentation broths.},
  author       = {LIN, Carol Sze Ki and Du, Chenyu and Blaga, Alexandra Cristina and Camarut, Maria and Webb, Colin and Stevens, Christian and Soetaert, Wim},
  issn         = {1463-9262},
  journal      = {GREEN CHEMISTRY},
  keywords     = {TECHNOLOGY,STRAIN,BIOREFINING STRATEGY,ORGANIC-ACIDS,ESCHERICHIA-COLI,ACTINOBACILLUS-SUCCINOGENES,ADSORPTION,STATE,YIELD},
  language     = {eng},
  number       = {4},
  pages        = {666--671},
  title        = {Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths},
  url          = {http://dx.doi.org/10.1039/b913021g},
  volume       = {12},
  year         = {2010},
}

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