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Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths

Carol Sze Ki LIN UGent, Chenyu Du, Alexandra Cristina Blaga, Maria Camarut, Colin Webb, Chris Stevens UGent and Wim Soetaert UGent (2010) GREEN CHEMISTRY. 12(4). p.666-671
abstract
In this paper, a novel resin-based crystallisation method was developed for the recovery of succinic acid (SA) crystals from fermentation broths (FB) using Actinobacillus succinogenes. Direct crystallisation of synthetic fermentation broths was firstly investigated and the results indicated that the synthetic fermentation broth consisting of a mixture of organic acids (in the free acid form rather than in the salt form) could significantly benefit in succinic acid recovery. Therefore, a commercially available cation-exchange resin Amberlite IR 120H was employed to convert the fermentation end-products such as succinate, formate, acetate and pyruvate from the salt form into the free acid form. Then, succinic acid was selectively separated from the acid mixture by vacuum evaporation and crystallisation. Highly purified SA crystals were successfully recovered from both synthetic and real fermentation broths using this method. A higher SA crystal purity (99%) and yield (89.5%) were obtained in the direct crystallisation method using an ion-exchange resin as compared to the direct acid addition method (46% and 35%, respectively). The work presented here sets the stage for the development of an efficient resin-based vacuum-distillation and crystallisation system for the recovery of succinic acid crystals from fermentation broths.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TECHNOLOGY, STRAIN, BIOREFINING STRATEGY, ORGANIC-ACIDS, ESCHERICHIA-COLI, ACTINOBACILLUS-SUCCINOGENES, ADSORPTION, STATE, YIELD
journal title
GREEN CHEMISTRY
Green Chem.
volume
12
issue
4
pages
6 pages
Web of Science type
Article
Web of Science id
000276973200021
JCR category
CHEMISTRY, MULTIDISCIPLINARY
JCR impact factor
5.472 (2010)
JCR rank
19/142 (2010)
JCR quartile
1 (2010)
ISSN
1463-9262
DOI
10.1039/b913021g
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
956487
handle
http://hdl.handle.net/1854/LU-956487
date created
2010-05-27 15:52:56
date last changed
2010-06-17 16:08:48
@article{956487,
  abstract     = {In this paper, a novel resin-based crystallisation method was developed for the recovery of succinic acid (SA) crystals from fermentation broths (FB) using Actinobacillus succinogenes. Direct crystallisation of synthetic fermentation broths was firstly investigated and the results indicated that the synthetic fermentation broth consisting of a mixture of organic acids (in the free acid form rather than in the salt form) could significantly benefit in succinic acid recovery. Therefore, a commercially available cation-exchange resin Amberlite IR 120H was employed to convert the fermentation end-products such as succinate, formate, acetate and pyruvate from the salt form into the free acid form. Then, succinic acid was selectively separated from the acid mixture by vacuum evaporation and crystallisation. Highly purified SA crystals were successfully recovered from both synthetic and real fermentation broths using this method. A higher SA crystal purity (99\%) and yield (89.5\%) were obtained in the direct crystallisation method using an ion-exchange resin as compared to the direct acid addition method (46\% and 35\%, respectively). The work presented here sets the stage for the development of an efficient resin-based vacuum-distillation and crystallisation system for the recovery of succinic acid crystals from fermentation broths.},
  author       = {LIN, Carol Sze Ki and Du, Chenyu and Blaga, Alexandra Cristina and Camarut, Maria and Webb, Colin and Stevens, Chris and Soetaert, Wim},
  issn         = {1463-9262},
  journal      = {GREEN CHEMISTRY},
  keyword      = {TECHNOLOGY,STRAIN,BIOREFINING STRATEGY,ORGANIC-ACIDS,ESCHERICHIA-COLI,ACTINOBACILLUS-SUCCINOGENES,ADSORPTION,STATE,YIELD},
  language     = {eng},
  number       = {4},
  pages        = {666--671},
  title        = {Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths},
  url          = {http://dx.doi.org/10.1039/b913021g},
  volume       = {12},
  year         = {2010},
}

Chicago
LIN, Carol Sze Ki, Chenyu Du, Alexandra Cristina Blaga, Maria Camarut, Colin Webb, Chris Stevens, and Wim Soetaert. 2010. “Novel Resin-based Vacuum Distillation-crystallisation Method for Recovery of Succinic Acid Crystals from Fermentation Broths.” Green Chemistry 12 (4): 666–671.
APA
LIN, C. S. K., Du, C., Blaga, A. C., Camarut, M., Webb, C., Stevens, C., & Soetaert, W. (2010). Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths. GREEN CHEMISTRY, 12(4), 666–671.
Vancouver
1.
LIN CSK, Du C, Blaga AC, Camarut M, Webb C, Stevens C, et al. Novel resin-based vacuum distillation-crystallisation method for recovery of succinic acid crystals from fermentation broths. GREEN CHEMISTRY. 2010;12(4):666–71.
MLA
LIN, Carol Sze Ki, Chenyu Du, Alexandra Cristina Blaga, et al. “Novel Resin-based Vacuum Distillation-crystallisation Method for Recovery of Succinic Acid Crystals from Fermentation Broths.” GREEN CHEMISTRY 12.4 (2010): 666–671. Print.