Ghent University Academic Bibliography

Advanced

Transcriptional control of gene expression by MicroRNAs

Basel Khraiwesh UGent, M Asif Arif, Gotelinde I Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski and Wolfgang Frank (2010) CELL. 140(1). p.111-122
abstract
MicroRNAs (miRNAs) control gene expression in animals and plants. Like another class of small RNAs, siRNAs, they affect gene expression posttranscriptionally. While siRNAs in addition act in transcriptional gene silencing, a role of miRNAs in transcriptional regulation has been less clear. We show here that in moss Physcomitrella patens mutants without a DICER-LIKE1b gene, maturation of miRNAs is normal but cleavage of target RNAs is abolished and levels of these transcripts are drastically reduced. These mutants accumulate miRNA: target-RNA duplexes and show hypermethylation of the genes encoding target RNAs, leading to gene silencing. This pathway occurs also in the wild-type upon hormone treatment. We propose that initiation of epigenetic silencing by DNA methylation depends on the ratio of the miRNA and its target RNA.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PLANTS, DICER HOMOLOG, MESSENGER-RNAS, MAMMALIAN-CELLS, C-ELEGANS, ARABIDOPSIS-THALIANA, PHYSCOMITRELLA-PATENS, TRANS-ACTING SIRNAS, DEPENDENT RNA-POLYMERASE, DIRECTED DNA METHYLATION
journal title
CELL
Cell
volume
140
issue
1
pages
111 - 122
Web of Science type
Article
Web of Science id
000273391900019
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
32.401 (2010)
JCR rank
1/284 (2010)
JCR quartile
1 (2010)
ISSN
0092-8674
DOI
10.1016/j.cell.2009.12.023
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
956199
handle
http://hdl.handle.net/1854/LU-956199
date created
2010-05-27 14:07:49
date last changed
2012-09-19 14:03:50
@article{956199,
  abstract     = {MicroRNAs (miRNAs) control gene expression in animals and plants. Like another class of small RNAs, siRNAs, they affect gene expression posttranscriptionally. While siRNAs in addition act in transcriptional gene silencing, a role of miRNAs in transcriptional regulation has been less clear. We show here that in moss Physcomitrella patens mutants without a DICER-LIKE1b gene, maturation of miRNAs is normal but cleavage of target RNAs is abolished and levels of these transcripts are drastically reduced. These mutants accumulate miRNA: target-RNA duplexes and show hypermethylation of the genes encoding target RNAs, leading to gene silencing. This pathway occurs also in the wild-type upon hormone treatment. We propose that initiation of epigenetic silencing by DNA methylation depends on the ratio of the miRNA and its target RNA.},
  author       = {Khraiwesh, Basel and Arif, M Asif  and Seumel, Gotelinde I and Ossowski, Stephan  and Weigel, Detlef  and Reski, Ralf  and  Frank, Wolfgang},
  issn         = {0092-8674},
  journal      = {CELL},
  keyword      = {PLANTS,DICER HOMOLOG,MESSENGER-RNAS,MAMMALIAN-CELLS,C-ELEGANS,ARABIDOPSIS-THALIANA,PHYSCOMITRELLA-PATENS,TRANS-ACTING SIRNAS,DEPENDENT RNA-POLYMERASE,DIRECTED DNA METHYLATION},
  language     = {eng},
  number       = {1},
  pages        = {111--122},
  title        = {Transcriptional control of gene expression by MicroRNAs},
  url          = {http://dx.doi.org/10.1016/j.cell.2009.12.023},
  volume       = {140},
  year         = {2010},
}

Chicago
Khraiwesh, Basel, M Asif Arif, Gotelinde I Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski, and Wolfgang Frank. 2010. “Transcriptional Control of Gene Expression by MicroRNAs.” Cell 140 (1): 111–122.
APA
Khraiwesh, B., Arif, M. A., Seumel, G. I., Ossowski, S., Weigel, D., Reski, R., & Frank, W. (2010). Transcriptional control of gene expression by MicroRNAs. CELL, 140(1), 111–122.
Vancouver
1.
Khraiwesh B, Arif MA, Seumel GI, Ossowski S, Weigel D, Reski R, et al. Transcriptional control of gene expression by MicroRNAs. CELL. 2010;140(1):111–22.
MLA
Khraiwesh, Basel, M Asif Arif, Gotelinde I Seumel, et al. “Transcriptional Control of Gene Expression by MicroRNAs.” CELL 140.1 (2010): 111–122. Print.