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The versatile role of MSKs in transcriptional regulation

Linda Vermeulen UGent, Wim Vanden Berghe UGent, Ilse Beck UGent, Karolien De Bosscher UGent and Guy Haegeman UGent (2009) TRENDS IN BIOCHEMICAL SCIENCES. 34(6). p.311-318
abstract
Among the mitogen-activated protein kinase (MAPK) targets, MSKs (mitogen- and stress-activated protein kinases) comprise a particularly interesting protein family. Because MSKs can be activated by both extracellular-signal-regulated kinase and p38 MAPKs, they are activated by many physiological and pathological stimuli. About ten years after their original discovery, they have been recognized as versatile kinases regulating gene transcription at multiple levels. MSKs directly target transcription factors, such as cAMP-response-element-binding protein and nuclear factor-kappaB, thereby enhancing their transcriptional activity. They also induce histone phosphorylation, which is accompanied by chromatin relaxation and facilitated binding of additional regulatory proteins. Here, we review the current knowledge on MSK activation and its molecular targets, focusing on recent insights into the role of MSKs at multiple levels of transcriptional regulation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
STRESS-ACTIVATED PROTEIN-KINASE-1, HUMAN SKELETAL-MUSCLE, SIGNAL-TRANSDUCTION, GENE-EXPRESSION, S6 KINASE-B, LESIONAL PSORIATIC EPIDERMIS, HISTONE H3 PHOSPHORYLATION, NF-KAPPA-B, ELEMENT-BINDING PROTEIN, TUMOR-NECROSIS-FACTOR
journal title
TRENDS IN BIOCHEMICAL SCIENCES
Trends Biochem.Sci.
volume
34
issue
6
pages
311 - 318
Web of Science type
Review
Web of Science id
000267717200006
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
11.572 (2009)
JCR rank
12/281 (2009)
JCR quartile
1 (2009)
ISSN
0968-0004
DOI
10.1016/j.tibs.2009.02.007
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
955774
handle
http://hdl.handle.net/1854/LU-955774
date created
2010-05-27 11:32:15
date last changed
2010-07-16 13:49:21
@article{955774,
  abstract     = {Among the mitogen-activated protein kinase (MAPK) targets, MSKs (mitogen- and stress-activated protein kinases) comprise a particularly interesting protein family. Because MSKs can be activated by both extracellular-signal-regulated kinase and p38 MAPKs, they are activated by many physiological and pathological stimuli. About ten years after their original discovery, they have been recognized as versatile kinases regulating gene transcription at multiple levels. MSKs directly target transcription factors, such as cAMP-response-element-binding protein and nuclear factor-kappaB, thereby enhancing their transcriptional activity. They also induce histone phosphorylation, which is accompanied by chromatin relaxation and facilitated binding of additional regulatory proteins. Here, we review the current knowledge on MSK activation and its molecular targets, focusing on recent insights into the role of MSKs at multiple levels of transcriptional regulation.},
  author       = {Vermeulen, Linda and Vanden Berghe, Wim and Beck, Ilse and De Bosscher, Karolien and Haegeman, Guy},
  issn         = {0968-0004},
  journal      = {TRENDS IN BIOCHEMICAL SCIENCES},
  keyword      = {STRESS-ACTIVATED PROTEIN-KINASE-1,HUMAN SKELETAL-MUSCLE,SIGNAL-TRANSDUCTION,GENE-EXPRESSION,S6 KINASE-B,LESIONAL PSORIATIC EPIDERMIS,HISTONE H3 PHOSPHORYLATION,NF-KAPPA-B,ELEMENT-BINDING PROTEIN,TUMOR-NECROSIS-FACTOR},
  language     = {eng},
  number       = {6},
  pages        = {311--318},
  title        = {The versatile role of MSKs in transcriptional regulation},
  url          = {http://dx.doi.org/10.1016/j.tibs.2009.02.007},
  volume       = {34},
  year         = {2009},
}

Chicago
Vermeulen, Linda, Wim Vanden Berghe, Ilse Beck, Karolien De Bosscher, and Guy Haegeman. 2009. “The Versatile Role of MSKs in Transcriptional Regulation.” Trends in Biochemical Sciences 34 (6): 311–318.
APA
Vermeulen, Linda, Vanden Berghe, W., Beck, I., De Bosscher, K., & Haegeman, G. (2009). The versatile role of MSKs in transcriptional regulation. TRENDS IN BIOCHEMICAL SCIENCES, 34(6), 311–318.
Vancouver
1.
Vermeulen L, Vanden Berghe W, Beck I, De Bosscher K, Haegeman G. The versatile role of MSKs in transcriptional regulation. TRENDS IN BIOCHEMICAL SCIENCES. 2009;34(6):311–8.
MLA
Vermeulen, Linda, Wim Vanden Berghe, Ilse Beck, et al. “The Versatile Role of MSKs in Transcriptional Regulation.” TRENDS IN BIOCHEMICAL SCIENCES 34.6 (2009): 311–318. Print.