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Pathophysiology of chronic rhinosinusitis

PETER TOMASSEN UGent, Thibaut Van Zele UGent, Nan Zhang UGent, Claudina Perez Novo UGent, NICHOLAS VAN BRUAENE UGent, Philippe Gevaert UGent and Claus Bachert UGent (2011) PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY. 8(1). p.115-120
abstract
Chronic rhinosinusitis (CRS), a disease presenting with chronic symptoms such as nasal obstruction, rhinorrhoea, hyposmia and facial pain, is highly prevalent and has a considerable impact on quality of life and health care expenditures. The disease is characterized by chronic inflammation of the sinonasal mucosa and can present with nasal polyps. Current consensus classifies CRS into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). This review illustrates the diversity of pathophysiological observations in CRS and highlights selected etiologic hypotheses. A wide spectrum of alterations is described in regard to histopathology, pattern of T cells and inflammatory effector cells, remodeling, immunoglobulin production, chemokine and eicosanoid production, and the role of microorganisms. The pathophysiological diversity observed in CRS seems to stand in contrast with the aspecific clinical presentation, but is of utmost importance in the development and application of highly individualized treatments. Identification of specific disease subgroups and their etiologies is an important and challenging task for future research.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
journal title
PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY
Proc. Am. Thorac. Soc.
volume
8
issue
1
pages
115 - 120
ISSN
1546-3222
DOI
10.1513/pats.201005-036RN
language
English
UGent publication?
yes
classification
A2
copyright statement
I have transferred the copyright for this publication to the publisher
id
948795
handle
http://hdl.handle.net/1854/LU-948795
date created
2010-05-19 11:20:55
date last changed
2011-05-16 15:09:20
@article{948795,
  abstract     = {Chronic rhinosinusitis (CRS), a disease presenting with chronic symptoms such as nasal obstruction, rhinorrhoea, hyposmia and facial pain, is highly prevalent and has a considerable impact on quality of life and health care expenditures. The disease is characterized by chronic inflammation of the sinonasal mucosa and can present with nasal polyps. Current consensus classifies CRS into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). This review illustrates the diversity of pathophysiological observations in CRS and highlights selected etiologic hypotheses. A wide spectrum of alterations is described in regard to histopathology, pattern of T cells and inflammatory effector cells, remodeling, immunoglobulin production, chemokine and eicosanoid  production, and the role of microorganisms. The pathophysiological diversity observed in CRS seems to stand in contrast  with the aspecific clinical presentation, but is of utmost importance in the development and application of highly individualized treatments. Identification of specific disease subgroups and their etiologies is an important and challenging task for future research.},
  author       = {TOMASSEN, PETER and Van Zele, Thibaut and Zhang, Nan and Perez Novo, Claudina and VAN BRUAENE, NICHOLAS and Gevaert, Philippe and Bachert, Claus},
  issn         = {1546-3222},
  journal      = {PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY},
  language     = {eng},
  number       = {1},
  pages        = {115--120},
  title        = {Pathophysiology of chronic rhinosinusitis},
  url          = {http://dx.doi.org/10.1513/pats.201005-036RN},
  volume       = {8},
  year         = {2011},
}

Chicago
TOMASSEN, PETER, Thibaut Van Zele, Nan Zhang, Claudina Perez Novo, NICHOLAS VAN BRUAENE, Philippe Gevaert, and Claus Bachert. 2011. “Pathophysiology of Chronic Rhinosinusitis.” Proceedings of the American Thoracic Society 8 (1): 115–120.
APA
TOMASSEN, P., Van Zele, T., Zhang, N., Perez Novo, C., VAN BRUAENE, N., Gevaert, P., & Bachert, C. (2011). Pathophysiology of chronic rhinosinusitis. PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY, 8(1), 115–120.
Vancouver
1.
TOMASSEN P, Van Zele T, Zhang N, Perez Novo C, VAN BRUAENE N, Gevaert P, et al. Pathophysiology of chronic rhinosinusitis. PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY. 2011;8(1):115–20.
MLA
TOMASSEN, PETER, Thibaut Van Zele, Nan Zhang, et al. “Pathophysiology of Chronic Rhinosinusitis.” PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY 8.1 (2011): 115–120. Print.