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Interaction of porcine intestinal epithelial cells and dendritic cells with enterotoxigenic E. coli virulence factors and immune complexes

Bert Devriendt UGent (2010)
abstract
F4+ enterotoxigenic E. coli (ETEC) are an important cause of neonatal and postweaning diarrhoea in piglets, resulting in severe economic losses in swine husbandry. The main virulence factors associated with this pathogen are F4 fimbriae and enterotoxins. The F4 fimbriae mediate the attachment of the pathogen to F4-specific receptors expressed on the surface of intestinal epithelial cells and are therefore one of the important focuses of vaccination strategies to prevent F4+ ETEC-induced pathogenesis. It has been demonstrated that F4 fimbriae are highly immunogenic and that this potent immunogenicity results from their stability in the gastrointestinal tract, their polymeric nature and their interaction with epithelial receptors, leading to endocytosis and transcytosis of the fimbriae. However, data from other immunisation models indicate that early signals from intestinal epithelial cells (IEC) and/or dendritic cells (DC) direct the mucosal immune response. Therefore, we studied the interaction of F4 fimbriae with both cell types in order to improve vaccine design against F4+ ETEC infection in swine. Furthermore, some environmental factors, such as food contaminants, can influence the mucosal immune response. For instance, the food contaminant FB1 induces immunosuppression, leading to an enhanced susceptibility to infections and interference with vaccinations. However, the mechanisms by which FB1 exerts these effects remain elusive.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
F4 fimbriae, virulence factors, intestinal epithelial cells, cytokines, dendritic cells, maturation, porcine, fumonisin, enterotoxigenic E. coli
pages
197 pages
publisher
Ghent University. Faculty of Veterinary Medicine
place of publication
Merelbeke, Belgium
defense location
Merelbeke : Faculteit Diergeneeskunde (auditorium D)
defense date
2010-06-07 16:00
ISBN
9789058642219
language
English
UGent publication?
yes
classification
D1
additional info
dissertation in parts contains copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
947740
handle
http://hdl.handle.net/1854/LU-947740
date created
2010-05-18 11:00:00
date last changed
2010-06-15 10:37:50
@phdthesis{947740,
  abstract     = {F4+ enterotoxigenic E. coli (ETEC) are an important cause of neonatal and postweaning diarrhoea in piglets, resulting in severe economic losses in swine husbandry. The main virulence factors associated with this pathogen are F4 fimbriae and enterotoxins. The F4 fimbriae mediate the attachment of the pathogen to F4-specific receptors expressed on the surface of intestinal epithelial cells and are therefore one of the important focuses of vaccination strategies to prevent F4+ ETEC-induced pathogenesis. It has been demonstrated that F4 fimbriae are highly immunogenic and that this potent immunogenicity results from their stability in the gastrointestinal tract, their polymeric nature and their interaction with epithelial receptors, leading to endocytosis and transcytosis of the fimbriae. However, data from other immunisation models indicate that early signals from intestinal epithelial cells (IEC) and/or dendritic cells (DC) direct the mucosal immune response. Therefore, we studied the interaction of F4 fimbriae with both cell types in order to improve vaccine design against F4+ ETEC infection in swine. Furthermore, some environmental factors, such as food contaminants, can influence the mucosal immune response. For instance, the food contaminant FB1 induces immunosuppression, leading to an enhanced susceptibility to infections and interference with vaccinations. However, the mechanisms by which FB1 exerts these effects remain elusive.},
  author       = {Devriendt, Bert},
  isbn         = {9789058642219},
  keyword      = {F4 fimbriae,virulence factors,intestinal epithelial cells,cytokines,dendritic cells,maturation,porcine,fumonisin,enterotoxigenic E. coli},
  language     = {eng},
  pages        = {197},
  publisher    = {Ghent University. Faculty of Veterinary Medicine},
  school       = {Ghent University},
  title        = {Interaction of porcine intestinal epithelial cells and dendritic cells with enterotoxigenic E. coli virulence factors and immune complexes},
  year         = {2010},
}

Chicago
Devriendt, Bert. 2010. “Interaction of Porcine Intestinal Epithelial Cells and Dendritic Cells with Enterotoxigenic E. Coli Virulence Factors and Immune Complexes”. Merelbeke, Belgium: Ghent University. Faculty of Veterinary Medicine.
APA
Devriendt, B. (2010). Interaction of porcine intestinal epithelial cells and dendritic cells with enterotoxigenic E. coli virulence factors and immune complexes. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vancouver
1.
Devriendt B. Interaction of porcine intestinal epithelial cells and dendritic cells with enterotoxigenic E. coli virulence factors and immune complexes. [Merelbeke, Belgium]: Ghent University. Faculty of Veterinary Medicine; 2010.
MLA
Devriendt, Bert. “Interaction of Porcine Intestinal Epithelial Cells and Dendritic Cells with Enterotoxigenic E. Coli Virulence Factors and Immune Complexes.” 2010 : n. pag. Print.